The Korean journal of internal medicine

  • 제32권1호
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  • Pages.137-145
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  • 2017
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Relationship between serum IgA level and allergy/asthma

  • Kim, Woo-Jin (Department of Allergy, Chonnam National University Medical School, Graduate School and Research Institute of Medical Sciences) ;
  • Choi, Inseon S. (Department of Allergy, Chonnam National University Medical School, Graduate School and Research Institute of Medical Sciences) ;
  • Kim, Chang Seong (Department of Allergy, Chonnam National University Medical School, Graduate School and Research Institute of Medical Sciences) ;
  • Lee, Jeong-Hyeon (Department of Allergy, Chonnam National University Medical School, Graduate School and Research Institute of Medical Sciences) ;
  • Kang, Hyeon-Wook (Department of Allergy, Chonnam National University Medical School, Graduate School and Research Institute of Medical Sciences)
  • 투고 : 2014.05.30
  • 심사 : 2015.06.14
  • 발행 : 2017.01.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Mucosal immunoglobulin A (IgA) may prevent the entrance of allergens. This study examined the relationship between serum IgA levels (within the normal range) and sensitization to house dust mites (HDM) or airway hyper-responsiveness (AHR). Methods: The clinical records of 1,136 adult patients with suspected asthma, for whom test data for serum IgA level and methacholine-AHR were available, were reviewed retrospectively. The AHR/allergy indices were compared among patient groups with low (<140 mg/dL, group I), intermediate (140 to 280 mg/dL, group II), or high (${\geq}280mg/dL$, group III) IgA levels in serum. Results: The HDM skin sensitization rate progressively decreased from 30.0% in group I (n = 139) to 26.8% and 18.5% in groups II (n = 684) and III (n = 313), respectively (p = 0.003). Although both the HDM sensitization degree and the IgA level were significantly related to age, the adjusted odds ratio (OR) of association of a high IgA level (${\geq}280mg/dL$) with HDM sensitization was significant (0.617; 95% confidence interval [CI], 0.415 to 0.916; p = 0.017). Among younger subjects (${\leq}45$ years of age) with AHR, the prevalence of moderate/severe AHR progressively decreased (70.6%, 52.3%, and 47.1% in groups I, II, and III [n = 34, 149, and 51]), respectively (p = 0.045). The IgA < 140 mg/dL was a significant risk factor for moderate/severe AHR (OR, 2.306; 95% CI, 1.049 to 5.071; p = 0.038). Conclusions: Sensitization to HDM and methacholine-AHR were significantly associated with serum IgA levels in suspected asthmatics, even when those levels were normal.

키워드

참고문헌

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