The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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The predictive value of echocardiography for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism in Korea

  • Park, Jin Sup (Division of Cardiology, Medical Research Institute, Department of Internal Medicine, Pusan National University Hospital) ;
  • Ahn, Jinhee (Division of Cardiology, Medical Research Institute, Department of Internal Medicine, Pusan National University Hospital) ;
  • Choi, Jung Hyun (Division of Cardiology, Medical Research Institute, Department of Internal Medicine, Pusan National University Hospital) ;
  • Lee, Hye Won (Division of Cardiology, Medical Research Institute, Department of Internal Medicine, Pusan National University Hospital) ;
  • Oh, Jun-Hyok (Division of Cardiology, Medical Research Institute, Department of Internal Medicine, Pusan National University Hospital) ;
  • Lee, Han Cheol (Division of Cardiology, Medical Research Institute, Department of Internal Medicine, Pusan National University Hospital) ;
  • Cha, Kwang Soo (Division of Cardiology, Medical Research Institute, Department of Internal Medicine, Pusan National University Hospital) ;
  • Hong, Taek Jong (Division of Cardiology, Medical Research Institute, Department of Internal Medicine, Pusan National University Hospital)
  • Received : 2014.06.16
  • Accepted : 2015.03.23
  • Published : 2017.01.01
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Abstract

Background/Aims: Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening complication after acute pulmonary embolism (APE) and is associated with substantial morbidity and mortality. This study aimed to investigate the incidence of CTEPH after APE in Korea and to determine echocardiographic predictors of CTEPH. Methods: Among 381 patients with APE confirmed by chest computed tomography (CT) between January 2007 and July 2013, 246 consecutive patients with available echocardiographic data were enrolled in this study. CTEPH was defined as a persistent right ventricular systolic pressure (RVSP) greater than 35 mmHg on echocardiography during follow-up and persistent pulmonary embolism on the follow-up CT. Results: Fifteen patients (6.1%) had CTEPH. The rate of right ventricular (RV) dilatation (66.7% vs. 28.1%, p = 0.002) and the RVSP (75.5 mmHg vs. 39.0 mmHg, p < 0.001) were significantly higher in the CTEPH group. D-dimers, RV dilatation, RV hypertrophy, RVSP, and intermediate-risk APE were associated with the risk of CTEPH after APE (odds ratio [OR] 0.59, 5.11, 7.82, 1.06, and 4.86, respectively) on univariate analysis. RVSP remained as a significant predictor of CTEPH on multivariate analysis (OR, 1.056; 95% confidence interval, 1.006 to 1.109; p = 0.029). Conclusions: This study showed that the incidence of CTEPH after APE in Korea was 6.1% and that initial RVSP by echocardiography was a strong prognostic factor for CTEPH.

Keywords

Acknowledgement

Supported by : Pusan National University

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