The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Impact of random urine proteinuria on maternal and fetal outcomes of pregnancy: a retrospective case-control study

  • Bae, Eun Hui (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Kim, Jong Woon (Department of Obsterics, Chonnam National University Medical School) ;
  • Choi, Hong Sang (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Ma, Seong Kwon (Department of Internal Medicine, Chonnam National University Medical School) ;
  • Kim, Soo Wan (Department of Internal Medicine, Chonnam National University Medical School)
  • Received : 2016.01.07
  • Accepted : 2016.05.06
  • Published : 2017.11.01
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Abstract

Background/Aims: Proteinuria is associated with hypertension and preeclampsia in pregnancy. However, the impact of random urine proteinuria on fetal and maternal outcomes has not been established. We investigated the influence of random urine proteinuria on the clinical outcomes of pregnancy. Methods: From January 2008 to December 2010, 2,822 patients were retrospectively studied. A total of 536 pregnant women with proteinuria in random urine and matched controls without proteinuria via propensity score matching were analyzed. Proteinuria was checked by the dipstick method. Results: The patients' mean age was $33.0{\pm}4.7years$, and the mean gestational age was $235.6{\pm}50.6days$ on admission. The prevalence of hypertension and chronic kidney disease was 2.4% (n = 67) and 1.0% (n = 29), respectively. Women with random urine proteinuria showed higher blood urea nitrogen levels and a higher incidence of hematuria. These women also had a higher incidence of preeclampsia, preterm labor, premature rupture of membranes, and intrauterine growth restriction. Proteinuria was strongly correlated with preeclampsia in both propensity score matching (p < 0.001, r = 0.783) and unmatched whole samples (p < 0.001, r = 0.851). Conclusions: These findings suggest that random urine proteinuria is associated with preeclampsia, preterm labor, premature rupture of membrane, and intrauterine growth restriction.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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