The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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p22phox C242T gene polymorphism and overt diabetic nephropathy: a meta-analysis of 1,452 participants

  • Li, Yan-yan (Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University) ;
  • Gong, Ge (Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University) ;
  • Geng, Hong-yu (Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University) ;
  • Qian, Yun (Department of Geriatrics, First Affiliated Hospital of Nanjing Medical University)
  • Received : 2015.04.18
  • Accepted : 2015.07.20
  • Published : 2017.11.01
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Abstract

Background/Aims: The p22phox C242T gene polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive. Methods: To explore the relationship between p22phox C242T gene polymorphism and ODN, the current meta-analysis of 707 ODN patients and 745 controls from five individual studies was conducted. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were evaluated by either a random or fixed effect model. Results: In our meta-analysis, a significant relationship between the p22phox C242T gene polymorphism and ODN was found under allelic (OR, 2.760; 95% CI, 1.400 to 5.450; p = 0.004), recessive (OR, 5.080; 95% CI, 1.020 to 25.430; p = 0.05), dominant (OR, 1.700; 95% CI, 1.167 to 2.477; p = 0.006), homozygous (OR, 3.900; 95% CI, 1.022 to 14.889; p = 0.046), heterozygous (OR, 1.523; 95% CI, 1.167 to 1.986; p = 0.002), and additive genetic models (OR, 2.019; 95% CI, 1.232 to 3.309; p = 0.005). Conclusions: A positive correlation between p22phox C242T gene polymorphism and ODN risk was found. The T allele carriers of p22phox C242T gene polymorphism might be predisposed to ODN.

Keywords

Acknowledgement

Supported by : National Natural Science Foundation of China, Nanjing Medical University

References

  1. Adarkwah CC, Gandjour A, Akkerman M, Evers SM. Cost-effectiveness of angiotensin-converting enzyme inhibitors for the prevention of diabetic nephropathy in the Netherlands: a Markov model. PLoS One 2011;6:e26139. https://doi.org/10.1371/journal.pone.0026139
  2. Foley RN, Collins AJ. The growing economic burden of diabetic kidney disease. Curr Diab Rep 2009;9:460-465. https://doi.org/10.1007/s11892-009-0075-9
  3. Tzamaloukas AH, Murata GH. Prevention of nephropathy in patients with type 2 diabetes mellitus. Int Urol Nephrol 2005;37:655-663. https://doi.org/10.1007/s11255-005-2394-3
  4. Conserva F, Pontrelli P, Accetturo M, Gesualdo L. The pathogenesis of diabetic nephropathy: focus on microRNAs and proteomics. J Nephrol 2013;26:811-20. https://doi.org/10.5301/jn.5000262
  5. Bhatt AP, Gupta A, Vibha D, Sharma A, Mahajan S. Florid diabetic complications in impaired glucose tolerance. Saudi J Kidney Dis Transpl 2013;24:86-88. https://doi.org/10.4103/1319-2442.106251
  6. Najafi M, Alipoor B, Shabani M, Amirfarhangi A, Ghasemi H. Association between rs4673 (C/T) and rs13306294 (A/G) haplotypes of NAD(P)H oxidase p22phox gene and severity of stenosis in coronary arteries. Gene 2012;499:213-217. https://doi.org/10.1016/j.gene.2012.02.032
  7. Perianayagam MC, Liangos O, Kolyada AY, et al. NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure. J Am Soc Nephrol 2007;18:255-263. https://doi.org/10.1681/ASN.2006070806
  8. Hodgkinson AD, Millward BA, Demaine AG. Association of the p22phox component of NAD(P)H oxidase with susceptibility to diabetic nephropathy in patients with type 1 diabetes. Diabetes Care 2003;26:3111-5. https://doi.org/10.2337/diacare.26.11.3111
  9. Liu LY, Zou DJ, Zhang J. Association between NADPH oxidase subunit p22phox gene polymorphism and type 2 diabetic nephropathy patients in Shanghai. Chin J Nephrol 2006;22:84-87.
  10. Yang ST, Liu H, Wang YM, Song DP. The polymorphism of C242T of p22phox gene related to diabetic nephropathy. J Kunming Med Univ 2006;27:111-115.
  11. Lim SC, Goh SK, Lai YR, et al. Relationship between common functional polymorphisms of the p22phox gene (-930A > G and +242C > T) and nephropathy as a result of type 2 diabetes in a Chinese population. Diabet Med 2006;23:1037-1041. https://doi.org/10.1111/j.1464-5491.2006.01916.x
  12. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009;6:e1000097. https://doi.org/10.1371/journal.pmed.1000097
  13. Cochran WG. The effectiveness of adjustment by subclassification in removing bias in observational studies. Biometrics 1968;24:295-313. https://doi.org/10.2307/2528036
  14. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-188. https://doi.org/10.1016/0197-2456(86)90046-2
  15. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719-748.
  16. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-634. https://doi.org/10.1136/bmj.315.7109.629
  17. Santos KG, Canani LH, Gross JL, Tschiedel B, Souto KE, Roisenberg I. Relationship of p22phox C242T polymorphism with nephropathy in type 2 diabetic patients. J Nephrol 2005;18:733-738.
  18. Hong YR, Han L, Huang J, Kleinberg ME. Elimination of false negative results in the two-hybrid system in the phagocyte NADPH oxidase. Kaohsiung J Med Sci 1996;12:301-305.
  19. Inoue N, Kawashima S, Kanazawa K, Yamada S, Akita H, Yokoyama M. Polymorphism of the NADH/NADPH oxidase p22 phox gene in patients with coronary artery disease. Circulation 1998;97:135-137. https://doi.org/10.1161/01.CIR.97.2.135
  20. Guzik TJ, West NE, Black E, et al. Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis. Circulation 2000;102:1744-1747. https://doi.org/10.1161/01.CIR.102.15.1744
  21. Liu CC, Karimi Galougahi K, Weisbrod RM, et al. Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent ${\beta}1$-subunit glutathionylation: implications for angiotensin II-induced vascular dysfunction. Free Radic Biol Med 2013;65:563-572. https://doi.org/10.1016/j.freeradbiomed.2013.06.040
  22. Cahilly C, Ballantyne CM, Lim DS, Gotto A, Marian AJ. A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis. Circ Res 2000;86:391-395. https://doi.org/10.1161/01.RES.86.4.391
  23. Ito D, Murata M, Watanabe K, et al. C242T polymorphism of NADPH oxidase p22 PHOX gene and ischemic cerebrovascular disease in the Japanese population. Stroke 2000;31:936-939. https://doi.org/10.1161/01.STR.31.4.936
  24. Ji Z, Lu BX, Wang XY, Pan SY. C242T p22phox gene polymorphism in the population of Han nationality in Guangdong province. Di Yi Jun Yi Da Xue Xue Bao 2003;23:387-388, 390.
  25. Li A, Prasad A, Mincemoyer R, et al. Relationship of the C242T p22phox gene polymorphism to angiographic coronary artery disease and endothelial function. Am J Med Genet 1999;86:57-61. https://doi.org/10.1002/(SICI)1096-8628(19990903)86:1<57::AID-AJMG11>3.0.CO;2-R
  26. Saha N, Sanghera DK, Kamboh MI. The p22 phox polymorphism C242T is not associated with CHD risk in Asian Indians and Chinese. Eur J Clin Invest 1999;29:999-1002. https://doi.org/10.1046/j.1365-2362.1999.00575.x

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