The Korean journal of internal medicine

  • 제32권5호
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  • Pages.883-889
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  • 2017
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Caveolin-1 is involved in high glucose accelerated human glomerular mesangial cell senescence

  • Feng, Xin (Department of Rheumatology, The First Affiliated Hospital of Liaoning Medical University) ;
  • Gao, Wei (Department of Rheumatology, The First Affiliated Hospital of Liaoning Medical University) ;
  • Li, Yao (Department of Physiology, Liaoning Medical University)
  • 투고 : 2015.08.01
  • 심사 : 2015.10.15
  • 발행 : 2017.09.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: We demonstrated the role of caveolin-1 involved in high glucose (HG)-induced glomerular mesangial cells (GMCs) senescence. Methods: HG was used to stimulate GMCs. The telomere lengths were analyzed by Southern blot. ${\beta}$-Galactosidase staining was determined. The expressions of caveolin-1 and P53 proteins were determined by Western blot. Results: Treatment with high concentrations of glucose induced GMC senescence accompanied by shortened telomere length and increase of ${\beta}$-galactosidase staining as well as P53 protein, which was abrogated after application of caveolin-1-siRNA. Conclusions: This study proved that HG induced cell senescence in GMCs. The caveolin-1 is involved in HG-induced mesangial cell senescence, and blocking caveolin-1 significantly reduced cell senescence. The effect of caveolin-1 is mediated by P53 pathway.

키워드

과제정보

연구 과제 주관 기관 : Liaoning Medical University

참고문헌

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피인용 문헌

  1. Upregulation of MiR-126 Delays the Senescence of Human Glomerular Mesangial Cells Induced by High Glucose via Telomere-p53-p21-Rb Signaling Pathway vol.38, pp.5, 2017, https://doi.org/10.1007/s11596-018-1942-x
  2. Caveolin-1 as a critical component in the pathogenesis of lung fibrosis of different etiology: Evidences and mechanisms vol.111, pp.None, 2017, https://doi.org/10.1016/j.yexmp.2019.104315
  3. Caveolin-1, a master regulator of cellular senescence vol.39, pp.2, 2017, https://doi.org/10.1007/s10555-020-09875-w
  4. Recent developments in the regulation of cholesterol transport by natural molecules vol.35, pp.10, 2021, https://doi.org/10.1002/ptr.7198