The Korean journal of internal medicine

  • 제32권3호
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  • Pages.452-458
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  • 2017
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Incidence and clinical characteristics of gastroenteropancreatic neuroendocrine tumor in Korea: a single-center experience

  • Lim, Chul-Hyun (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Lee, In Seok (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Jun, Byoung Yeon (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Jin Su (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Cho, Yu Kyung (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Park, Jae Myung (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Roh, Sang Young (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Lee, Myung Ah (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Kim, Sang Woo (Department of Internal Medicine, College of Medicine, The Catholic University of Korea) ;
  • Choi, Myung-Gyu (Department of Internal Medicine, College of Medicine, The Catholic University of Korea)
  • 투고 : 2015.07.21
  • 심사 : 2015.12.03
  • 발행 : 2017.05.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Neuroendocrine tumors (NETs) may originate from heterogeneous neuroendocrine cells. The incidence is increasing worldwide, and World Health Organization (WHO) updated its classification in 2010. We investigated clinical characteristics of gastroenteropancreatic NETs in a single center. Methods: Clinicopathologic characteristics of patients with pathologically confirmed gastroenteropancreatic NET in Seoul St. Mary Hospital from March 2009 to August 2011 were retrospectively analyzed. The grade and stage were determined according to WHO 2010 classification and TNM Staging System for Neuroendocrine Tumors (7th ed., 2010) of American Joint Committee on Cancer. Results: One hundred and twenty-five patients (median age, 50; male, 61.3%) were analyzed. Among 100,000 patients who visited the hospital, incidence was 24.1. Only two patients (1.6%) had a functional NET. The rectum (n = 99, 79.8%) was most common primary site and found in early stage. The prevalence by stages was 84.7% stage I, 8.9% stage IV, 4.8% stage II, and 1.6% stage III. The pathology grading was 74.5% grade 1, 12.7% grade 2, and 12.7% grade 3. Tumor stage correlated positively with pathologic grade (Spearman's rank correlation coefficient, 0.644). Conclusions: Wide range of clinicopathological features of Korean gastroenteropancreatic NETs were demonstrated using WHO 2010 classification. Rectal NET was most frequent and found in early stage.

키워드

참고문헌

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