DOI QR코드

DOI QR Code

Association between thyroid autoimmunity and Helicobacter pylori infection

  • Choi, Yun Mi (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Tae Yong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Eui Young (Department of Internal Medicine, Dongnam Institute of Radiological & Medical Sciences) ;
  • Jang, Eun Kyung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jeon, Min Ji (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Won Gu (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Shong, Young Kee (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Won Bae (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 투고 : 2014.12.01
  • 심사 : 2015.06.15
  • 발행 : 2017.03.01

초록

Background/Aims: There have been controversial reports linking Helicobacter pylori infection to autoimmune thyroid disease (AITD). However, data regarding the relationship are limited for Asian populations, which have an extremely high prevalence of H. pylori infection. We performed this study to investigate the association between H. pylori infection and AITD in Koreans. Methods: This study involved adults aged 30 to 70 years who had visited a health promotion center. A total of 5,502 subjects were analysed. Thyroid status was assessed by free thyroxine, thyroid stimulating hormone, and anti-thyroid peroxidase antibody (TPO-Ab). Immunoglobulin G (IgG) antibodies to H. pylori were measured as an indication of H. pylori infection. We compared the prevalence of TPO-Ab in subjects with and without H. pylori infection. Results: H. pylori IgG antibodies were found in 2,875 subjects (52.3%), and TPO-Ab were found in 430 (7.8%). Individuals positive for H. pylori Ab were older than those negative for H. pylori Ab (p < 0.01). The proportion of females was significantly higher in the TPO-Ab positive group (41.0% vs. 64.2%, p < 0.01). Prevalence of TPO-Ab positivity was higher in subjects with H. pylori infection (8.6% vs. 7.00%, p = 0.03), and this association was significant after adjusting for age, sex, and body mass index (odds ratio, 1.02; 95% confidence interval, 1.00 to 1.03; p = 0.04). Conclusions: In our study, prevalence of TPO-Ab positivity is more frequent in subjects with H. pylori infection. Our findings suggest H. pylori infection may play a role in the development of autoimmune thyroiditis.

키워드

과제정보

연구 과제 주관 기관 : Asan Institute for Life Sciences

참고문헌

  1. Fountoulakis S, Tsatsoulis A. On the pathogenesis of autoimmune thyroid disease: a unifying hypothesis. Clin Endocrinol (Oxf) 2004;60:397-409. https://doi.org/10.1046/j.1365-2265.2004.01978.x
  2. Kim YA, Park YJ. Prevalence and risk factors of subclinical thyroid disease. Endocrinol Metab (Seoul) 2014;29:20-29. https://doi.org/10.3803/EnM.2014.29.1.20
  3. Hybenova M, Hrda P, Prochazkova J, Stejskal V, Sterzl I. The role of environmental factors in autoimmune thyroiditis. Neuro Endocrinol Lett 2010;31:283-289.
  4. Tomer Y, Davies TF. Infection, thyroid disease, and autoimmunity. Endocr Rev 1993;14:107-120.
  5. Bassi V, Marino G, Iengo A, Fattoruso O, Santinelli C. Autoimmune thyroid diseases and Helicobacter pylori: the correlation is present only in Graves's disease. World J Gastroenterol 2012;18:1093-1097. https://doi.org/10.3748/wjg.v18.i10.1093
  6. Bertalot G, Montresor G, Tampieri M, et al. Decrease in thyroid autoantibodies after eradication of Helicobacter pylori infection. Clin Endocrinol (Oxf) 2004;61:650-652. https://doi.org/10.1111/j.1365-2265.2004.02137.x
  7. Franceschi F, Satta MA, Mentella MC, et al. Helicobacter pylori infection in patients with Hashimoto's thyroiditis. Helicobacter 2004;9:369. https://doi.org/10.1111/j.1083-4389.2004.00241.x
  8. Larizza D, Calcaterra V, Martinetti M, et al. Helicobacter pylori infection and autoimmune thyroid disease in young patients: the disadvantage of carrying the human leukocyte antigen-DRB1*0301 allele. J Clin Endocrinol Metab 2006;91:176-179. https://doi.org/10.1210/jc.2005-1272
  9. Papamichael KX, Papaioannou G, Karga H, Roussos A, Mantzaris GJ. Helicobacter pylori infection and endocrine disorders: is there a link? World J Gastroenterol 2009;15:2701-2707. https://doi.org/10.3748/wjg.15.2701
  10. Shi WJ, Liu W, Zhou XY, Ye F, Zhang GX. Associations of Helicobacter pylori infection and cytotoxin-associated gene A status with autoimmune thyroid diseases: a meta-analysis. Thyroid 2013;23:1294-1300. https://doi.org/10.1089/thy.2012.0630
  11. Soveid M, Hosseini Asl K, Omrani GR. Infection by Cag A positive strains of Helicobacter pylori is associated with autoimmune thyroid disease in Iranian patients. Iran J Immunol 2012;9:48-52.
  12. Sterzl I, Hrda P, Matucha P, Cerovska J, Zamrazil V. Anti-Helicobacter pylori, anti-thyroid peroxidase, anti-thyroglobulin and anti-gastric parietal cells antibodies in Czech population. Physiol Res 2008;57 Suppl 1:S135-S141.
  13. Tomasi PA, Dore MP, Fanciulli G, Sanciu F, Realdi G, Delitala G. Is there anything to the reported association between Helicobacter pylori infection and autoimmune thyroiditis? Dig Dis Sci 2005;50:385-388. https://doi.org/10.1007/s10620-005-1615-z
  14. Bassi V, Fattoruso O, Polistina MT, Santinelli C. Graves' disease shows a significant increase in the Helicobacter pylori recurrence. Clin Endocrinol (Oxf) 2014;81:784-785. https://doi.org/10.1111/cen.12410
  15. Kim N, Kim JJ, Choe YH, et al. Diagnosis and treatment guidelines for Helicobacter pylori infection in Korea. Korean J Gastroenterol 2009;54:269-278. https://doi.org/10.4166/kjg.2009.54.5.269
  16. Faria C, Zakout R, Araujo M. Helicobacter pylori and autoimmune diseases. Biomed Pharmacother 2013;67:347-349. https://doi.org/10.1016/j.biopha.2011.09.015
  17. Ram M, Barzilai O, Shapira Y, et al. Helicobacter pylori serology in autoimmune diseases: fact or fiction? Clin Chem Lab Med 2013;51:1075-1082.
  18. Jung JH, Choi KD, Han S, et al. Seroconversion rates of Helicobacter pylori infection in Korean adults. Helicobacter 2013;18:299-308. https://doi.org/10.1111/hel.12043
  19. Bae SE, Jung HY, Kang J, et al. Effect of Helicobacter pylori eradication on metachronous recurrence after endoscopic resection of gastric neoplasm. Am J Gastroenterol 2014;109:60-67. https://doi.org/10.1038/ajg.2013.404
  20. Wasserman EE, Nelson K, Rose NR, et al. Infection and thyroid autoimmunity: a seroepidemiologic study of TPOaAb. Autoimmunity 2009;42:439-446. https://doi.org/10.1080/08916930902787716
  21. Orgiazzi J. Thyroid autoimmunity. Presse Med 2012;41(12 P 2):e611-e625. https://doi.org/10.1016/j.lpm.2012.10.002
  22. Prummel MF, Strieder T, Wiersinga WM. The environment and autoimmune thyroid diseases. Eur J Endocrinol 2004;150:605-618. https://doi.org/10.1530/eje.0.1500605
  23. Elisei R, Mariotti S, Swillens S, Vassart G, Ludgate M. Studies with recombinant autoepitopes of thyroid peroxidase: evidence suggesting an epitope shared between the thyroid and the gastric parietal cell. Autoimmunity 1990;8:65-70. https://doi.org/10.3109/08916939008998434
  24. Stechova K, Pomahacova R, Hrabak J, et al. Reactivity to Helicobacter pylori antigens in patients suffering from thyroid gland autoimmunity. Exp Clin Endocrinol Diabetes 2009;117:423-431. https://doi.org/10.1055/s-0029-1214385
  25. Huang JQ, Zheng GF, Sumanac K, Irvine EJ, Hunt RH. Meta-analysis of the relationship between cagA seropositivity and gastric cancer. Gastroenterology 2003;125:1636-1644. https://doi.org/10.1053/j.gastro.2003.08.033
  26. Lim SH, Kwon JW, Kim N, et al. Prevalence and risk factors of Helicobacter pylori infection in Korea: nationwide multicenter study over 13 years. BMC Gastroenterol 2013;13:104. https://doi.org/10.1186/1471-230X-13-104

피인용 문헌

  1. Biological evidence of the relationship between Helicobacter pylori and associated extragastric diseases vol.120, pp.8, 2019, https://doi.org/10.1002/jcb.28681
  2. Systematic review and meta‐analysis: Effect of Helicobacter pylori eradication on chronic spontaneous urticaria vol.24, pp.6, 2017, https://doi.org/10.1111/hel.12661
  3. Microbial dysbiosis and microbiota-gut-retina axis: The lesson from brain neurodegenerative diseases to primary open-angle glaucoma pathogenesis of autoimmunity vol.66, pp.4, 2017, https://doi.org/10.1556/030.66.2019.038
  4. Helicobacter pylori Infection and Autoimmune Thyroid Diseases: The Role of Virulent Strains vol.9, pp.1, 2017, https://doi.org/10.3390/antibiotics9010012
  5. Association between Helicobacter pylori infection and Guillain‐Barré Syndrome: A meta‐analysis vol.50, pp.5, 2017, https://doi.org/10.1111/eci.13218
  6. Review: Extragastric diseases and Helicobacter pylori vol.25, pp.suppl, 2017, https://doi.org/10.1111/hel.12741
  7. Relationship between Helicobacter pylori infection and Hashimoto’s thyroiditis: A prospective study vol.29, pp.2, 2017, https://doi.org/10.11569/wcjd.v29.i2.75
  8. Relationship between Helicobacter pylori infection and Hashimoto’s thyroiditis: A prospective study vol.29, pp.2, 2017, https://doi.org/10.11569/wcjd.v29.i2.75
  9. Benefits of Helicobacter pylori Eradication on Extragastric Diseases vol.21, pp.4, 2017, https://doi.org/10.7704/kjhugr.2021.0041