The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Clinical significance of serum vascular endothelial growth factor in young male asthma patients

  • Lee, Hea Yon (Division of Allergy and Pulmonary Medicine, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea) ;
  • Min, Kyung Hoon (Division of Respiratory Medicine, Department of Internal Medicine, Korea University Guro Hospital) ;
  • Lee, Sang Min (Department of Internal Medicine, Gachon University Gil Medical Center) ;
  • Lee, Ji Eun (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The Armed Forces Capital Hospital) ;
  • Rhee, Chin Kook (Division of Allergy and Pulmonary Medicine, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea)
  • Received : 2014.08.12
  • Accepted : 2015.05.22
  • Published : 2017.03.01
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Abstract

Background/Aims: Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. However, little is known about the potential use of serum levels of VEGF as a biomarker for asthma. We investigated the differences in VEGF levels among normal controls, stable asthma patients, and those with exacerbation of acute asthma. All subjects were young males. Methods: We measured VEGF levels in each patient group, and examined any serial changes in those with acute exacerbation. Results: VEGF levels were significantly higher in stable asthmatic patients and even more so in acute asthmatic patients, compared to healthy controls. However, there was no correlation between VEGF levels and forced expiratory volume in 1 second in patients with stable asthma. In addition, there were no correlations between VEGF levels and asthma control test scores. In patients with acute exacerbation, VEGF levels significantly increased during the acute period; their levels decreased gradually at 7 and 14 days after treatment. Conclusions: Compared to normal control patients, the serum levels of VEGF were elevated in stable asthma patients and even more elevated in patients with acute exacerbation. However, the role of VEGF as a biomarker in stable asthma is limited. In patients with acute exacerbation, VEGF levels were associated with clinical improvements.

Keywords

References

  1. Bara I, Ozier A, Tunon de Lara JM, Marthan R, Berger P. Pathophysiology of bronchial smooth muscle remodelling in asthma. Eur Respir J 2010;36:1174-1184. https://doi.org/10.1183/09031936.00019810
  2. Li X, Wilson JW. Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med 1997;156:229-233. https://doi.org/10.1164/ajrccm.156.1.9607066
  3. Wilson J. The bronchial microcirculation in asthma. Clin Exp Allergy 2000;30 Suppl 1:51-53. https://doi.org/10.1046/j.1365-2222.2000.00098.x
  4. Zanini A, Chetta A, Imperatori AS, Spanevello A, Olivieri D. The role of the bronchial microvasculature in the airway remodelling in asthma and COPD. Respir Res 2010;11:132. https://doi.org/10.1186/1465-9921-11-132
  5. Bergeron C, Tulic MK, Hamid Q. Airway remodelling in asthma: from benchside to clinical practice. Can Respir J 2010;17:e85-e93. https://doi.org/10.1155/2010/318029
  6. Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001;107:295-301. https://doi.org/10.1067/mai.2001.111928
  7. Detoraki A, Granata F, Staibano S, Rossi FW, Marone G, Genovese A. Angiogenesis and lymphangiogenesis in bronchial asthma. Allergy 2010;65:946-958. https://doi.org/10.1111/j.1398-9995.2010.02372.x
  8. Ribatti D. The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review. Br J Haematol 2005;128:303-309. https://doi.org/10.1111/j.1365-2141.2004.05291.x
  9. Mura M, dos Santos CC, Stewart D, Liu M. Vascular endothelial growth factor and related molecules in acute lung injury. J Appl Physiol (1985) 2004;97:1605-1617. https://doi.org/10.1152/japplphysiol.00202.2004
  10. Lee CG, Link H, Baluk P, et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 2004;10:1095-1103. https://doi.org/10.1038/nm1105
  11. Wen FQ, Liu X, Manda W, et al. TH2 cytokine-enhanced and TGF-beta-enhanced vascular endothelial growth factor production by cultured human airway smooth muscle cells is attenuated by IFN-gamma and corticosteroids. J Allergy Clin Immunol 2003;111:1307-1318. https://doi.org/10.1067/mai.2003.1455
  12. Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143-178. https://doi.org/10.1183/09031936.00138707
  13. Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J 2005;26:319-338. https://doi.org/10.1183/09031936.05.00034805
  14. Wanger J, Clausen JL, Coates A, et al. Standardisation of the measurement of lung volumes. Eur Respir J 2005;26:511-522. https://doi.org/10.1183/09031936.05.00035005
  15. Kanazawa H, Hirata K, Yoshikawa J. Involvement of vascular endothelial growth factor in exercise induced bronchoconstriction in asthmatic patients. Thorax 2002;57:885-888. https://doi.org/10.1136/thorax.57.10.885
  16. Asai K, Kanazawa H, Otani K, Shiraishi S, Hirata K, Yoshikawa J. Imbalance between vascular endothelial growth factor and endostatin levels in induced sputum from asthmatic subjects. J Allergy Clin Immunol 2002;110:571-575. https://doi.org/10.1067/mai.2002.127797
  17. Asai K, Kanazawa H, Kamoi H, Shiraishi S, Hirata K, Yoshikawa J. Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients. Clin Exp Allergy 2003;33:595-599. https://doi.org/10.1046/j.1365-2222.2003.01576.x
  18. Papadaki G, Bakakos P, Kostikas K, et al. Vascular endothelial growth factor and cysteinyl leukotrienes in sputum supernatant of patients with asthma. Respir Med 2013;107:1339-1345. https://doi.org/10.1016/j.rmed.2013.06.014
  19. Abdel-Rahman AM, el-Sahrigy SA, Bakr SI. A comparative study of two angiogenic factors: vascular endothelial growth factor and angiogenin in induced sputum from asthmatic children in acute attack. Chest 2006;129:266-271. https://doi.org/10.1378/chest.129.2.266
  20. Feltis BN, Wignarajah D, Zheng L, et al. Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma. Am J Respir Crit Care Med 2006;173:1201-1207. https://doi.org/10.1164/rccm.200507-1105OC
  21. Zou H, Fang QH, Ma YM, Wang XY. Analysis of growth factors in serum and induced sputum from patients with asthma. Exp Ther Med 2014;8:573-578. https://doi.org/10.3892/etm.2014.1759
  22. Bikov A, Bohacs A, Eszes N, et al. Circulating and exhaled vascular endothelial growth factor in asthmatic pregnancy. Biomarkers 2012;17:648-654. https://doi.org/10.3109/1354750X.2012.713004
  23. Lee KY, Lee KS, Park SJ, et al. Clinical significance of plasma and serum vascular endothelial growth factor in asthma. J Asthma 2008;45:735-739. https://doi.org/10.1080/02770900802216775
  24. Meyer N, Akdis CA. Vascular endothelial growth factor as a key inducer of angiogenesis in the asthmatic airways. Curr Allergy Asthma Rep 2013;13:1-9. https://doi.org/10.1007/s11882-012-0317-9
  25. Farid Hosseini R, Jabbari Azad F, Yousefzadeh H, et al. Serum levels of vascular endothelial growth factor in chronic obstructive pulmonary disease. Med J Islam Repub Iran 2014;28:85.
  26. Zampeli E, Karamanolis G, Morfopoulos G, et al. Increased expression of VEGF, COX-2, and Ki-67 in Barrett's esophagus: does the length matter? Dig Dis Sci 2012;57:1190-1196. https://doi.org/10.1007/s10620-011-1990-6
  27. Lee CG, Ma B, Takyar S, et al. Studies of vascular endothelial growth factor in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 2011;8:512-515. https://doi.org/10.1513/pats.201102-018MW
  28. Kanazawa H, Tochino Y, Ichimaru Y, Kodama T, Kyoh S, Umeda N. Role of vascular endothelial growth factor in pulmonary endothelial cell injury by exercise challenge in asthmatic patients. J Asthma 2006;43:267-271. https://doi.org/10.1080/02770900600622653
  29. Kanazawa H. Microvascular theory of exercise-induced bronchoconstriction in asthma: potential implication of vascular endothelial growth factor. Inflamm Allergy Drug Targets 2007;6:133-137. https://doi.org/10.2174/187152807780832256

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