Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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The Distribution and Characteristics of Abnormal Findings Regarding Fasting Plasma Glucose and HbA1c - Based on Adults Except for Known Diabetes

공복혈당과 당화혈색소를 적용한 당뇨병 이상소견자의 분포 및 특성 - 당뇨병 기진단자를 제외한 성인을 대상으로

  • Kwon, Seyoung (Department of Biomedical Laboratory Science, Daegu Health College) ;
  • Na, Youngak (Department of Biomedical Laboratory Science, Daegu Health College)
  • 권세영 (대구보건대학교 임상병리과) ;
  • 나영악 (대구보건대학교 임상병리과)
  • Received : 2017.07.29
  • Accepted : 2017.08.14
  • Published : 2017.09.30
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Abstract

Among the commonly known tools to diagnose diabetes are fasting plasma glucose (FPG), HbA1c., and OGTT known as gold standard. However, there can be many disagreements on the ways to diagnose diabetes. In this study, we examined the differences of the types of diabetes according to the applicability of FPG and HbA1c. Moreover, we evaluated the concordance of diagnosis. We excluded subjects with missing glucose and HbA1c data, as well as those previously diagnosed with diabetes, and those who fasted less than 8 hours. The data of 4,502 subjects (1,956 men and 2,546 women) from the 2015 KNHNES were analyzed. We divided these patients into three categories which are normal, prediabetes, and diabetes, based on the FPG and HbA1c. In men, the number of subjects with FPG ranging from 100 to 125 mg/dL and HbA1c ${\geq}6.5%$ was 23 out of 664, and the number of subjects with FPG < 126 mg/dL and HbA1c ${\geq}6.5%$ was 39 out of 86 newly diagnosed diabetes patients. The concordance rate was as follows: Normal 80.3%, prediabetes 44.9%, and diabetes 54.7%. The coefficient of Cohen's Kappa was 0.322 in men and 0.362 in women; this suggests that both gender showed a low concordance rate. However, when we divided them into two categories (nondiabetes and diabetes), Kappa was 0.582 in men and 0.637 in women, showing a relatively high concordance rate. While all subjects with FPG ${\geq}126mg/dL$ showed a significantly high HOMA IR, all subjects with FPG < 126 mg/dL showed a significantly high QUICKI. Considering the low concordance rate for the diagnosis of diabetes and characteristic of diagnostic tests, it is necessary to combine the related tests for diagnosing diabetes.

현재 임상에서 적용되고 있는 대표적인 당뇨 진단 기준에는 표준검사법인 경구당부하검사, 공복혈당, 당화혈색소가 있다. 그러나, 검사별로 판정이 일치하지 않는 경우가 많다. 본 연구에서는 선별검사에서 행해지는 공복혈당과 당화혈색소를 이용하여 당뇨병 판정의 일치도를 구해보고, 유형별로 그 특성을 살펴 보았다. 국민건강영양조사 데이터(2015) 중 측정치 누락자, 당뇨병 기진단자, 공복 8시간 미만인 자를 제외한 20세 이상 대상자 4,502명(남성 1,956명, 여성 2,546명)의 자료를 이용하였다. 공복혈당과 당화혈색소 농도를 당뇨병 진단기준의 세 범주(정상, 당뇨병 전단계, 당뇨병)로 나누어 살펴본 남성 대상자의 분포에서 공복혈당 100 mg/dL~125 mg/dL이면서 HbA1c ${\geq}6.5%$인 대상자는 664명 중 23명, 새롭게 진단된 당뇨군 86명 중 39명은 공복혈당 ${\geq}126mg/dL$ 이면서 HbA1c < 6.5%로 나타났다. 판정의 일치율은 비당뇨군 80.3% 당뇨군 54.7%, 당뇨병 전단계에서 44.9%로 가장 낮았다. 코헨의 kappa 값은 남성의 경우 0.322, 여성의 경우 0.362로 일치도가 낮게 나타났고, 두 범주(비당뇨병, 당뇨병)로 나누었을 때 남성의 경우 0.582, 여성의 경우 0.637로 나타나 더 높은 일치도를 보였다. 공복혈당 <126 mg/dL이며 HbA1c < 6.5%인 군에서 연령도 낮고 대부분의 혈액 측정치도 낮게 나타났으며, 공복혈당 ${\geq}126mg/dL$ 이면서 HbA1c ${\geq}6.5%$인 군에서 남성의 경우 허리둘레, 혈압, 총 콜레스테롤, 중성지방의 수치가 높고 여성의 경우 ALT, hsCRP가 높게 나타났다. 남녀 모두 공복혈당 ${\geq}126mg/dL$인 군에서 인슐린저항성 지표인 HOMA IR값이 유의하게 높았고, <126 mg/dL인 군에서 인슐린감수성 지표인 QUICKI 값이 유의하게 높았다. 당뇨병 판정의 낮은 일치도 및 진단검사의 특성을 고려하여 관련검사의 병행 해석이 필요하다.

Keywords

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