Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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The Serum Levels of LD and CRP in Patients of Coal Workers' Pneumoconiosis with Chronic Obstructive Pulmonary Disease

만성폐쇄성폐질환을 동반한 탄광부진폐증자의 혈청 중 LD 및 CRP 농도

  • Lee, Jong Seong (Occupational Lung Diseases Research Institute, Korea Workers' Compensation & Welfare Service) ;
  • Shin, Jae Hoon (Occupational Lung Diseases Research Institute, Korea Workers' Compensation & Welfare Service) ;
  • Lee, YouLim (Occupational Lung Diseases Research Institute, Korea Workers' Compensation & Welfare Service) ;
  • Baek, JinEe (Occupational Lung Diseases Research Institute, Korea Workers' Compensation & Welfare Service) ;
  • Choi, Byung-Soon (Occupational Lung Diseases Research Institute, Korea Workers' Compensation & Welfare Service)
  • 이종성 (근로복지공단 직업성폐질환연구소) ;
  • 신재훈 (근로복지공단 직업성폐질환연구소) ;
  • 이유림 (근로복지공단 직업성폐질환연구소) ;
  • 백진이 (근로복지공단 직업성폐질환연구소) ;
  • 최병순 (근로복지공단 직업성폐질환연구소)
  • Received : 2017.05.24
  • Accepted : 2017.07.11
  • Published : 2017.09.30
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Abstract

Coal workers' pneumoconiosis (CWP) and chronic obstructive pulmonary disease (COPD) are characterized as chronic inflammation of the lung in miners exposed to coal mine dust. The aim of the present study was to compare the levels of serum lactate dehydrogenase (LD) and C-reactive protein (CRP) as the inflammatory indices between subjects with CWP and those with CWP and COPD (CWP+COPD), among a total of 97 subjects (27 control, 40 CWP, and 30 CWP+COPD patients). The mean levels of serum LD (165.7 vs 184.6 U/L, p=0.016) and CRP (0.08 vs 0.15 mg/dL, p=0.002) in subjects with CWP were higher than those of in subjects without CWP. The mean level of serum CRP (0.10 vs 0.19 mg/dL, p=0.008) in subjects with COPD was higher than that in subjects without COPD. In an analysis of covariance adjusted by age, the mean level of serum CRP showed statistical significance among the study groups, control, CWP, and CWP+COPD (0.07 vs 0.13 vs 0.19 mg/dL, p=0.005); the mean level of serum CRP in the CWP+COPD group was significantly higher than that of the control group (p=0.001). The results suggest that a high level of CRP in the serum may be associated with CWP and COPD in retired coal miners.

탄광부진폐증(CWP)과 만성폐쇄성폐질환(COPD)은 석탄분진에 노출되는 탄광부의 폐에서 나타나는 만성적 폐 염증의 특성을 가진다. 이번 연구의 목적은 대조군 27명, CWP 40명, COPD를 동반한 CWP 30명 등 총97명을 대상으로 염증지표로서 혈청 중의 LD와 CRP 수준을 비교하고자 하였다. 혈청 중의 LD 평균 농도(165.7 vs 184.6 U/L, p=0.016)와 CRP 평균 농도(0.08 vs 0.15 mg/dL, p=0.002)는 CWP군에서 유의하게 높았다. 혈청 중의 CRP 평균 농도(0.10 vs 0.19 mg/dL, p=0.008)는 COPD군에서 높았다. 연령을 통제한 공분산분석에서, 혈청 중 CRP 평균 농도는 대조군, CWP군 및 CWP+COPD군 간에 통계적으로 유의한 차이가 있었으며(0.07 vs 0.13 vs 0.19 mg/dL, p=0.005), CWP+COPD 군의 혈청 CRP 평균 농도가 대조군보다 유의하게 높았다(p=0.001). 이러한 결과는 높은 수준의 혈청 중 CRP는 탄광부 이직근로자에서의 CWP 및 COPD와 관련이 있는 것으로 보인다.

Keywords

References

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