KSBB Journal

  • 제32권2호
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  • Pages.146-152
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  • 2017
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  • 1225-7117(pISSN)
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  • 2288-8268(eISSN)
한국생물공학회 (The Korean Society for Biotechnology and Bioengineering)
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질 내 유산균의 Candida albicans에 대한 항진균 효과 연구

Characterization and Antifungal Activity against Candida albicans of Vaginal Lactobacillus spp. Isolated from Korean Women

  • Jung, Yeojung (Department of Biological Engineering, Inha University) ;
  • Kang, Chang-Ho (Department of Biological Engineering, Inha University) ;
  • Shin, YuJin (Department of Biological Engineering, Inha University) ;
  • So, Jae-Seong (Department of Biological Engineering, Inha University)
  • 투고 : 2016.12.09
  • 심사 : 2017.06.20
  • 발행 : 2017.06.30
⟨ 이전 논문 다음 논문 ⟩

초록

Vulvovaginal candidiasis (VVC) is one of the urogenital infections occurring in women worldwide. Candida albicans is generally observed among various types of microorganisms causing VVC. Antibiotic therapy is typical, and the use of Lactobacilli probiotics is to be recognized as a promising alternative. The aim of this study was to select vaginal lactobacilli with probiotic properties against C. albicans. In a previous study, we isolated 38 lactobacilli from vagina of Korean women and 20 isolates were shown to inhibit C. albicans. We further selected 10 isolates which were able to inhibit C. albicans less than $10^5CFU/mL$. Among these selected strains, Lactobacillus salivarius MG242 (identified by 16s rRNA sequencing) was finally selected based on its strong anti-candidal activity, acid/bile salt resistance and adhesion property. Indirect adhesion activity of MG242 measured by auto-aggregation assay showed more than 60% auto-aggregation after 5 h standing. Taken these results together, the selected strain MG242 may have potential for application in vagina health related products.

키워드

참고문헌

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