Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Pentastomiasis at the Left Maxilla Bone in a Patient with Thyroid Cancer

  • Cho, Eunae Sandra (Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry) ;
  • Jung, Seung Wook (Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry) ;
  • Jung, Hwi-Dong (Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry) ;
  • Lee, In Yong (Department of Environmental Medical Biology, Institute of Tropical Medicine & Arthropods of Medical Importance Bank, Yonsei University College of Medicine) ;
  • Yong, Tai-Soon (Department of Environmental Medical Biology, Institute of Tropical Medicine & Arthropods of Medical Importance Bank, Yonsei University College of Medicine) ;
  • Jeong, Su Jin (Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine) ;
  • Kim, Hyun Sil (Department of Oral Pathology, Oral Cancer Research Institute, Yonsei University College of Dentistry)
  • Received : 2017.04.25
  • Accepted : 2017.06.17
  • Published : 2017.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Pentastomiasis, a zoonotic parasite infection, is typically found in the respiratory tract and viscera of the host, including humans. Here, we report for the first time an extremely rare case of intraosseous pentastomiasis in the human maxilla suffering from medication related osteonecrosis of the jaw (MRONJ). A 55-year-old male had continuously visited the hospital for MRONJ which had primarily developed after bisphosphonate and anti-neoplastic administration for previous bone metastasis of medullary thyroid cancer. Pain, bone exposure, and pus discharge in the right mandible and left maxilla were seen. Osteolysis with maxillary cortical bone perforation at the left buccal vestibule, palate, nasal cavity, and maxillary sinus was observed by radiologic images. A biopsy was done at the left maxilla and through pathological evaluation, a parasite with features of pentastome was revealed within the necrotic bone tissue. Further history taking and laboratory evaluation was done. The parasite was suspected to be infected through maxillary open wounds caused by MRONJ. Awareness of intraosseous pentastomiasis should be emphasized not to be missed behind the MRONJ. Proper evaluation and interpretation for past medical history may lead to correct differential diagnosis and therapeutic intervention for parasite infections.

Keywords

References

  1. Drabick JJ. Pentastomiasis. Rev Infect Dis 1987; 9: 1087-1094. https://doi.org/10.1093/clinids/9.6.1087
  2. Riley J. The biology of pentastomids. Adv Parasitol 1986; 25: 45-128.
  3. Vanhecke C, Le-Gall P, Le Breton M, Malvy D. Human pentastomiasis in Sub-Saharan Africa. Med Mal Infect 2016; 46: 269-275. https://doi.org/10.1016/j.medmal.2016.02.006
  4. Sulyok M, Rozsa L, Bodo I, Tappe D, Hardi R. Ocular pentastomiasis in the Democratic Republic of the Congo. PLoS Negl Trop Dis 2014; 8: e3041. https://doi.org/10.1371/journal.pntd.0003041
  5. Latif B, Omar E, Heo CC, Othman N, Tappe D. Human pentastomiasis caused by Armillifer moniliformis in Malaysian Borneo. Am J Trop Med Hyg 2011; 85: 878-881. https://doi.org/10.4269/ajtmh.2011.11-0404
  6. Tappe D, Buttner DW. Diagnosis of human visceral pentastomiasis. PLoS Negl Trop Dis 2009; 3: e320. https://doi.org/10.1371/journal.pntd.0000320
  7. Neva FA, Brown HW. Basic Clinical Parasitology. 6th ed. Norwalk, Connecticut. Appleton & Lange. 1994.
  8. Park CS, Kim MW, Hong WK, Lee HB, Lee DW, Kang DY, Chai JY, Lee SH. Pentastomiasis which caused eosinophilic pneumonia: report of a case. J Korean Med Assoc 1985; 28: 1141-1146.
  9. Jisieike-Onuigbo NN, Odenigbo CU, Kalu OA, Eze KC. Armillifer armillatus infection. Niger J Clin Pract 2011; 14: 501-503. https://doi.org/10.4103/1119-3077.91767
  10. Yazdani R, Sharifi I, Bamorovat M, Mohammadi MA. Human linguatulosis caused by Linguatula serrata in the city of Kerman, South-eastern Iran- case report. Iran J Parasitol 2014; 9: 282-285.
  11. Papadakis AM, Hourmouziadis AN. Human infestation with Linguatula serrata; report of a case. Trans R Soc Trop Med Hyg 1958; 52: 454-455. https://doi.org/10.1016/0035-9203(58)90132-9
  12. Morsy TA, El-Sharkawy IM, Lashin AH. Human nasopharyngeal linguatuliasis (Pentasomida) caused by Linguatula serrata. J Egypt Soc Parasitol 1999; 29: 787-790.
  13. Bhende M, Biswas J, Raman M, Bhende PS. Linguatula serrata in the anterior chamber of the eye. Indian J Ophthalmol 2014; 62: 1159-1161. https://doi.org/10.4103/0301-4738.149145
  14. Koehsler M, Walochnik J, Georgopoulos M, Pruente C, Boeckeler W, Auer H, Barisani-Asenbauer T. Linguatula serrata tongue worm in human eye, Austria. Emerg Infect Dis 2011; 17: 870-872. https://doi.org/10.3201/eid1705.100790
  15. Lazo RF, Hidalgo E, Lazo JE, Bermeo A, Llaguno M, Murillo J, Teixeira VP. Ocular linguatuliasis in Ecuador: case report and morphometric study of the larva of Linguatula serrata. Am J Trop Med Hyg 1999; 60: 405-409. https://doi.org/10.4269/ajtmh.1999.60.405
  16. Yilmaz H, Cengiz ZT, Cicek M, Dulger AC. A nasopharyngeal human infestation caused by Linguatula serrata nymphs in Van province: a case report. Turkiye Parazitol Derg 2011; 35: 47-49. https://doi.org/10.5152/tpd.2011.12
  17. Tappe D, Dijkmans AC, Brienen EA, Dijkmans BA, Ruhe IM, Netten MC, van Lieshout L. Imported Armillifer pentastomiasis: report of a symptomatic infection in The Netherlands and mini-review. Travel Med Infect Dis 2014; 12: 129-133. https://doi.org/10.1016/j.tmaid.2013.10.011
  18. Wang HY, Zhu GH, Luo SS, Jiang KW. Childhood pentastomiasis: a report of three cases with the following-up data. Parasitol Int 2013; 62: 289-292. https://doi.org/10.1016/j.parint.2013.02.007
  19. Tappe D, Sulyok M, Rozsa L, Muntau B, Haeupler A, Bodo I, Hardi R. Molecular diagnosis of abdominal Armillifer grandis pentastomiasis in the Democratic Republic of Congo. J Clin Microbiol 2015; 53: 2362-2364. https://doi.org/10.1128/JCM.00336-15
  20. Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. J Oral Maxillofac Surg 2014; 72: 1938-1956. https://doi.org/10.1016/j.joms.2014.04.031
  21. Boff RC, Salum FG, Figueiredo MA, Cherubini K. Important aspects regarding the role of microorganisms in bisphosphonate-related osteonecrosis of the jaws. Arch Oral Biol 2014; 59: 790-799. https://doi.org/10.1016/j.archoralbio.2014.05.002
  22. Ruggiero SL, Woo SB. Biophosphonate-related osteonecrosis of the jaws. Dent Clin North Am 2008; 52: 111-128. https://doi.org/10.1016/j.cden.2007.09.002
  23. Lombard T, Neirinckx V, Rogister B, Gilon Y, Wislet S. Medication-related osteonecrosis of the jaw: new insights into molecular mechanisms and cellular therapeutic approaches. Stem Cells Int 2016; 2016: 8768162.
  24. Bamias A, Kastritis E, Bamia C, Moulopoulos LA, Melakopoulos I, Bozas G, Koutsoukou V, Gika D, Anagnostopoulos A, Papadimitriou C, Terpos E, Dimopoulos MA. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: incidence and risk factors. J Clin Oncol 2005; 23: 8580-8587. https://doi.org/10.1200/JCO.2005.02.8670
  25. Cetiner S, Sucak GT, Kahraman SA, Aki SZ, Kocakahyaoglu B, Gultekin SE, Cetiner M, Haznedar R. Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid. J Bone Miner Metab 2009; 27: 435-443. https://doi.org/10.1007/s00774-009-0047-9
  26. Fusco V, Santini D, Armento G, Tonini G, Campisi G. Osteonecrosis of jaw beyond antiresorptive (bone-targeted) agents: new horizons in oncology. Expert Opin Drug Saf 2016; 15: 925-935. https://doi.org/10.1080/14740338.2016.1177021
  27. Giancola F, Campisi G, Lo Russo L, Muzio LL, Di Fede O. Osteonecrosis of the jaw related to everolimus and bisphosphonate: a unique case report? Ann Stomatol (Roma) 2013; 4 (suppl): 20-21.
  28. Kim DW, Jung YS, Park HS, Jung HD. Osteonecrosis of the jaw related to everolimus: a case report. Br J Oral Maxillofac Surg 2013; 51: e302-304. https://doi.org/10.1016/j.bjoms.2013.09.008
  29. Wei X, Pushalkar S, Estilo C, Wong C, Farooki A, Fornier M, Bohle G, Huryn J, Li Y, Doty S, Saxena D. Molecular profiling of oral microbiota in jawbone samples of bisphosphonate-related osteonecrosis of the jaw. Oral Dis 2012; 18: 602-612. https://doi.org/10.1111/j.1601-0825.2012.01916.x
  30. Sedghizadeh PP, Kumar SK, Gorur A, Schaudinn C, Shuler CF, Costerton JW. Microbial biofilms in osteomyelitis of the jaw and osteonecrosis of the jaw secondary to bisphosphonate therapy. J Am Dent Assoc 2009; 140: 1259-1265. https://doi.org/10.14219/jada.archive.2009.0049
  31. Arkun R. Parasitic and fungal disease of bones and joints. Semin Musculoskelet Radiol 2004; 8: 231-242. https://doi.org/10.1055/s-2004-835363
  32. Abd El Bagi ME, Sammak BM, Al Shahed MS, Yousef BA, Demuren OA, Al Jared M, Thagafi MA. Rare bone infections "excluding the spine". Eur Radiol 1999; 9: 1078-1087. https://doi.org/10.1007/s003300050794
  33. Laovachirasuwan P, Mootsikapun P, Maleewong W, Intapan PM. Intraosseous proliferative sparganosis presenting as a pathologic fracture: A case report and review of the literature. Southeast Asian J Trop Med Public Health 2015; 46: 558-563.
  34. Rajabi MT, Akbari-Kamrani M, Gharib MH, Rajabi MB, Amoli FA, Abrishami Y, Oestreicher J. Intraosseous orbital hydatid cyst: report of a rare case. Can J Ophthalmol 2014; 49: e40-43. https://doi.org/10.1016/j.jcjo.2013.12.006
  35. Arik HO, Arican M, Cetin NK, Sarp U. Primary intraosseous hydatid cyst of femur. Iran Red Crescent Med J 2015; 17: e21070.

Cited by

  1. Capecitabine/everolimus/zoledronic acid : Various toxicities: case report vol.1676, pp.1, 2017, https://doi.org/10.1007/s40278-017-38064-8
  2. Morphological and molecular description of Armillifer moniliformis larvae isolated from Sri Lankan brown palm civet (Paradoxurus montanus) vol.119, pp.3, 2017, https://doi.org/10.1007/s00436-019-06581-7
  3. Answer to January 2021 Photo Quiz vol.59, pp.1, 2017, https://doi.org/10.1128/jcm.00390-20