The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effects of Improving Alcohol Metabolism of Yeast Extract Mixtures and Hovenia dulcis Mixtures in Healthy Men - A Double-Blind, Randomized Crossover, Placebo-Controlled Trial -

효모추출복합물과 헛개나무 열매추출 복합물이 알코올 대사에 미치는 영향 - 무작위, 이중맹검, 위약 대조군, 교차 인체적용시험 -

  • Cho, Bo-Ram (Samyang Group Food R&D Center, Samyang Corporation) ;
  • Nam, Choong-Woo (Samyang Group Food R&D Center, Samyang Corporation) ;
  • Choung, Se-Young (Dept. of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University) ;
  • Jeong, In-Kyung (Dept. of Endocrinology and Metabolism, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine) ;
  • Moon, Min-Sun (Samyang Group Food R&D Center, Samyang Corporation)
  • 조보람 (삼양그룹 식품연구소) ;
  • 남충우 (삼양그룹 식품연구소) ;
  • 정세영 (경희대학교 약학대학) ;
  • 정인경 (경희대학교 의과대학 강동경희대학교병원 내분비대사내과) ;
  • 문민선 (삼양그룹 식품연구소)
  • Received : 2017.03.20
  • Accepted : 2017.06.30
  • Published : 2017.08.31
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Abstract

This study was conducted to investigate if the supplement formula may improve alcohol metabolism in healthy adult men. In a double-blinded, randomized, crossover study, subjects were administrated yeast extract mixtures (YEM, n=15), Hovenia dulcis mixtures (HDM, n=15), placebo (PLA, n=15), and control (CON, n=15) in an oral dose followed by one week washout periods. At each visit (0, 1, 2, 3, 4 week), subjects drank 450 mL, 20.1 percent alcohol after administered mixtures. Blood was drawn periodically (0, 0.25, 0.5, 1, 2, 4, 6, 15 hours). Fifteen subjects completed the protocol and were included in the analysis. Plasma ethanol concentration was lower in YEM (10 percent) and the HDM (5 percent) groups. The area under the curves (AUC) and $C_{max}$ for plasma ethanol were significantly decreased only in the YEM group, when compared with the CON group. The AUC and $C_{max}$ for plasma acetaldehyde concentration were significantly decreased in the YEM (45 and 54 percent) and the HDM (35 and 53 percent) groups respectively, when compared with PLA (p<0.01). Together, these findings validate that YEM or HDM improved alcohol metabolism and hangover syndromes, leading to reduce alcohol concentration and acetaldehyde concentration without adverse effects.

Keywords

References

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