The Journal of the Korea Contents Association (한국콘텐츠학회논문지)

The Korea Contents Association (한국콘텐츠학회)
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Association between the Polymorphism of Glutathione S-transferase Genes and Autoimmune Diseases in Asian Population: a Meta-analysis

아시아인종에서 자가면역질환과 GST 유전자 다형성의 메타분석

  • 김희성 (단국대학교 의과대학 제일병원 진단검사의학과)
  • Received : 2017.03.15
  • Accepted : 2017.05.02
  • Published : 2017.07.28
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Abstract

To verify the association between GSTM1/GSTT1 gene polymorphisms and susceptibility to autoimmune diseases in Asian population. 18 published reports cited in EMBASE, Google, KISS, MEDLINE and PubMed up to December 2015 were collected for a meta-analysis. The GSTM1/GSTT1 polymorphism for null and present type were analysed separately. The significant association was found between the GST polymorphism and autoimmune diseases in an overall population (GSTM1, OR=1.334, 95% CI=1.137-1.567, p=0.000; GSTT1, OR=1.212, 95% CI=1.012-1.452, p=0.037). Asian population showed the significant association of GSTM1 in the autoimmune diseases, especially vitiligo and atopic dermatitis but non-significant association of GSTT1 in RA and SLE. The GSTM1 null and the GSTT1 present type showed the association with autoimmune diseases in Asian population. The null type frequency of the combination of GSTM1-GSTT1 polymorphism in autoimmune diseases in Asian population was higher than that of the control group. This result indicated that null type of GSTM1-GSTT1 combination can be a risk factor of autoimmune diseases in Asian population.

아시아인종에서 GSTM1/GSTT1 유전자 다형성과 자가면역질환과 관련된 감수성을 검증하기 위해, 2015년 12월까지 EMBASE, Google, KISS, MEDLINE, PubMed에 발표된 18편의 논문들을 메타분석에 인용하였다. GSTM1/GSTT1 유전자의 null, present 유형을 개별적으로 분석하였다. 전체 인구에서 GST 다형성과 자가면역질환 사이에 연관성이 발견되었다(GSTM1, OR=1.334, 95% CI=1.137-1.567, p=0.000, GSTT1, OR=1.212, 95% CI=1.012-1.452, p=0.037). 아시아인종에서 자가면역질환, 특히 vitiligo와 아토피 피부염(p<0.05)에서 GSTM1 유전자와의 연관성이 있었고, RA와 SLE에서 GSTT1 유전자와의 연관성은 없었다(p>0.05). GSTM1 null 유형과 GSTT1 present 유형은 아시아인종에서 자가면역질환과 연관이 있었다(p<0.05). 자가면역질환과 GSTM1-GSTT1 다형성 조합 null 유형의 빈도는 대조군보다 높았다. 이와 같이, GSTM1-GSTT1 다형성 조합 null 유형이 아시아인종에서 자가면역질환의 위험 인자가 될 수 있다.

Keywords

References

  1. D. L. Jacobson, S. J. Gange, and N. R. Rose, "Epidemiology and estimated population burden of selected autoimmune diseases in the United States," Clin Immunol Immunopathol, Vol.84, pp.223-243, 1997. https://doi.org/10.1006/clin.1997.4412
  2. A. Wandstrat and E. Wakeland, "The genetics of complex autoimmune diseases: non-MHC susceptibility genes," Nat Immunol, Vol.2, pp.802-809, 2001. https://doi.org/10.1038/ni0901-802
  3. K. G. Becker, "Comparative genetics of type 1 diabetes and autoimmune disease: common loci, common pathways?," Diabetes, Vol.48, pp.1353-1358, 1999. https://doi.org/10.2337/diabetes.48.7.1353
  4. W. Maidhof and O. Hilas, "Lupus: an overview of the disease and management options." P & T, Vol.37, pp.240-249, 2012.
  5. G. J. Pons-Estel, G. S. Alarcon, and L. Scofield, "Understanding the epidemiology and progress ion of systemic lupus erythematosus," Seminars in arthritis and rheumatism, Vol.39, pp.257-268, 2010. https://doi.org/10.1016/j.semarthrit.2008.10.007
  6. G. C. Tsokos, "Systemic lupus erythematosus," The N Engl j Med, Vol.365, pp.2110-2121, 2011. https://doi.org/10.1056/NEJMra1100359
  7. R. Gualtierotti, M. Biggioggero, and A. E. Penatti, "Updating on the pathogenesis of systemic lupus erythematosus," Autoimmun rev, Vol.10, pp.3-7, 2010. https://doi.org/10.1016/j.autrev.2010.09.007
  8. J. D. Ji and W. J. Lee, "Association between the polymorphisms of glutathione S-transferase genes and rheumatoid arthritis: a meta-analysis," Gene, Vol.521, pp.155-159, 2013. https://doi.org/10.1016/j.gene.2013.03.023
  9. G. S. Firestein, "Evolving concepts of rheumatoid arthritis," Nature, Vol.423, pp.356-361, 2003. https://doi.org/10.1038/nature01661
  10. D. M. Lee and M. E. Weinblatt, "Rheumatoid arthritis," Lancet, Vol.358, pp.903-911, 2001. https://doi.org/10.1016/S0140-6736(01)06075-5
  11. D. L. Scott, F. Wolfe, and T. W. Huizinga, "Rheumatoid arthritis," Lancet, Vol.376, pp.1094-1108, 2010. https://doi.org/10.1016/S0140-6736(10)60826-4
  12. G. Orozco, S. Eyre, and A. Hinks, "Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study," Ann Rheum Dis, Vol.69, pp.813-816, 2010. https://doi.org/10.1136/ard.2009.109579
  13. A. M. Ghelani, A. Samanta, and A. C. Jones, "Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheuma toid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom," Rheuma tol int, Vol.31, pp.1355-1361, 2011. https://doi.org/10.1007/s00296-010-1478-2
  14. M. M. Fernando, C. R. Stevens, and E. C. Walsh, "Defining the role of the MHC in auto immunity: a review and pooled analysis," PLoS genetics, Vol.4, p.e1000024, 2008. https://doi.org/10.1371/journal.pgen.1000024
  15. G. G. Song, S. C. Bae, and Y. H. Lee, "The glutathione S-transferase M1 and P1 polymorphisms and rheumatoid arthritis: a meta-analysis," Mol Biol Rep, Vol.39, pp.10739-10745, 2012. https://doi.org/10.1007/s11033-012-1965-5
  16. E. W. Karlson, S. C. Chang, and J. Cui, "Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis," Ann Rheum Dis, Vol.69, pp.54-60, 2010. https://doi.org/10.1136/ard.2008.102962
  17. C. Kruger and K. U. Schallreuter, "A review of the worldwide prevalence of vitiligo in children/adolescents and adults," Int J Dermatol, Vol.51, pp.1206-1212, 2012. https://doi.org/10.1111/j.1365-4632.2011.05377.x
  18. M. Allam and H. Riad, "Concise review of recent studies in vitiligo," Qatar Med j, Vol.2013, pp.1-19, 2013. https://doi.org/10.5339/qmj.2013.1
  19. K. Ongenae, N. Van Geel, and J. M. Naeyaert, "Evidence for an autoimmune pathogenesis of vitiligo," Pigment Cell Res, Vol.16, pp.90-100, 2003. https://doi.org/10.1034/j.1600-0749.2003.00023.x
  20. S. Handa and I. Kaur, "Vitiligo: clinical findings in 1436 patients," J Dermatol, Vol.26, pp.653-657, 1999. https://doi.org/10.1111/j.1346-8138.1999.tb02067.x
  21. P. E. Grimes and R. Morris, "Avaniss-Aghajani E et al. Topical tacrolimus therapy for vitiligo: therapeutic responses and skin messenger RNA expression of proinflammatory cytokines," J Am Acad Dermatol, Vol.51, pp.52-61, 2004. https://doi.org/10.1016/j.jaad.2003.12.031
  22. V. M. Sheth, Y. Guo, and A. A. Qureshi, "Comorbidities associated with vitiligo: a ten-year retrospective study," Dermatology (Basel, Switzerland ), Vol.227, pp.311-315, 2013. https://doi.org/10.1159/000354607
  23. L. F. Eichenfield, W. L. Tom, and T. G. Berger, "Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies," J Am Acad Dermatol, Vol.71, pp.116-132, 2014. https://doi.org/10.1016/j.jaad.2014.03.023
  24. T. Bieber, "Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine," Allergy, Vol.67, pp.1475-1482, 2012.
  25. H. Tsukahara, R. Shibata, and Y. Ohshima, "Oxidative stress and altered antioxidant defenses in children with acute exacerbation of atopic dermatitis," Life Sci, Vol.72, pp.2509-2516, 2003. https://doi.org/10.1016/S0024-3205(03)00145-0
  26. G. K. Ching, K. L. Hon, and P. C. Ng, "Filaggrin null mutations in childhood atopic dermatitis among the Chinese," Int J Immuno genet, Vol.36, pp.251-254, 2009. https://doi.org/10.1111/j.1744-313X.2009.00859.x
  27. S. Weidinger, N. Klopp, and S. Wagenpfeil, "Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults," J Med Genet, Vol.41, pp.658-663, 2004. https://doi.org/10.1136/jmg.2004.020263
  28. S. Weidinger, E. Rodriguez, and C. Stahl, "Filaggr in mutations strongly predispose to early-onset and extrinsic atopic dermatitis," J Invest Derma tol, Vol.127, pp.724-726, 2007. https://doi.org/10.1038/sj.jid.5700630
  29. Y. H. Chien, W. L. Hwu, and B. L. Chiang, "The genetics of atopic dermatitis," Clin Rev Allergy Immunol, Vol.33, pp.178-190, 2007. https://doi.org/10.1007/s12016-007-0041-8
  30. M. Portugal, V. Barak, and I. Ginsburg, "Interplay among oxidants, antioxidants, and cytokines in skin disorders: present status and future considerations," Biomed Pharmacother, Vol.61, pp.412-422, 2007. https://doi.org/10.1016/j.biopha.2007.05.010
  31. N. Omata, H. Tsukahara, and S. Ito, "Increased oxidative stress in childhood atopic dermatitis," Life Sci, Vol.69, pp.223-228, 2001. https://doi.org/10.1016/S0024-3205(01)01124-9
  32. L. I. Holla, A. Stejskalova, and A. Vasku, "Polymorphisms of the GSTM1 and GSTT1 genes in patients with allergic diseases in the Czech population," Allergy, Vol.61, pp.265-267, 2006. https://doi.org/10.1111/j.1398-9995.2006.01000.x
  33. J. G. Millichap and M. M. Yee, "The diet factor in attention-deficit/hyperactivity disorder," Pediatri cs, Vol.129, pp.330-337, 2012. https://doi.org/10.1542/peds.2011-2199
  34. S. Y. Oh, J. Chung, and M. K. Kim, "Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children," Eur J Clin Nutr, Vol.64, pp.245-252, 2010. https://doi.org/10.1038/ejcn.2009.148
  35. P. D. Josephy, "Genetic variations in human glutathione transferase enzymes: significance for pharmacology and toxicology," Human genomics and proteomics : HGP, Vol.2010, p.876940, 2010.
  36. P. J. Jakobsson, S. Thoren, and R. Morgenstern, "Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target," Proc Natl Acad Sci U S A, Vol.96, pp.7220-7225, 1999. https://doi.org/10.1073/pnas.96.13.7220
  37. D. M. Townsend, K. D. Tew, and H. Tapiero, "The importance of glutathione in human disease," Biomed Pharmacother, Vol.57, pp.145-155, 2003. https://doi.org/10.1016/S0753-3322(03)00043-X
  38. P. Jemth, G. Stenberg, and G. Chaga, "Heterologous expression, purification and characterization of rat class theta glutathione transferase T2-2," Biochem J, Vol.316(Pt 1), pp.131-136, 1996. https://doi.org/10.1042/bj3160131
  39. B. T. Ashok and R. Ali, "Binding of human anti-DNA autoantibodies to reactive oxygen species modified-DNA and probing oxidative DNA damage in cancer using monoclonal antibody," International journal of cancer, Vol.78, pp.404-409, 1998. https://doi.org/10.1002/(SICI)1097-0215(19981109)78:4<404::AID-IJC2>3.0.CO;2-Y
  40. B. T. Ashok and R. Ali, "The aging paradox: free radical theory of aging," Exp Gerontol, Vol.34, pp.293-303, 1999. https://doi.org/10.1016/S0531-5565(99)00005-4
  41. B. Ardesjo, C. M. Hansson, and C. E. Bruder, "Autoantibodies to glutathione S-transferase theta 1 in patients with primary sclerosing cholangitis and other autoimmune diseases," J Autoimmun, Vol.30, pp.273-282, 2008. https://doi.org/10.1016/j.jaut.2007.11.008
  42. J. Chung, S. Y. Oh, and Y. K. Shin, "Association of glutathione S-transferase polymorphisms with atopic dermatitis risk in preschool age children," Clin Chem Lab Med, Vol.47, pp.1475-1481, 2009.
  43. I. J. Wang, Y. L. Guo, and T. J. Lin, "GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis," Ann Allergy Asthma Immunol, Vol.105, pp.124-129, 2010. https://doi.org/10.1016/j.anai.2010.04.017
  44. H. R. Cho, Y. K. Uhm, and H. J. Kim, "Glutathione S-transferase M1 (GSTM1) polymorphism is associated with atopic dermatitis susceptibility in a Korean population," Int J Immunogenet, Vol.38, pp.145-150, 2011. https://doi.org/10.1111/j.1744-313X.2010.00987.x
  45. J. Chung, S. O. Kwon, and H. Ahn, "Association between Dietary Patterns and Atopic Dermatitis in Relation to GSTM1 and GSTT1 Polymorphisms in Young Children," Nutrients, Vol.7, pp.9440-9452, 2015. https://doi.org/10.3390/nu7115473
  46. Y. K. Uhm, S. H. Yoon, and I. J. Kang, "Association of glutathione S-transferase gene polymorphisms (GSTM1 and GSTT1) of vitiligo in Korean population," Life Sci, Vol.81, pp.223-227, 2007. https://doi.org/10.1016/j.lfs.2007.05.006
  47. L. Liu, C. Li, and J. Gao, "Genetic polymorphisms of glutathione S-transferase and risk of vitiligo in the Chinese population," J Invest Dermatol, Vol.129, pp.2646-2652, 2009. https://doi.org/10.1038/jid.2009.143
  48. F. A. A. Rabou, H. Elserogy, and S. F. Gheida, "Glutathione S-Transferase Gene Polymorphisms (GSTM1 and GSTT1) in Vitiligo Patients," Life Science Journal, Vol.8, No.4, 2011.
  49. D. A. Bassiouny and M. M. Khorshied, "Glutathione S-transferase M1 and T1 genetic polymorphism in Egyptian patients with nonsegmental vitiligo," Clin Exp Dermatol, Vol.38, pp.160-163, 2013. https://doi.org/10.1111/j.1365-2230.2012.04413.x
  50. B. R. Yun, A. El-Sohemy, and M. C. Cornelis, "Glutathione S-transferase M1, T1, and P1 genotypes and rheumatoid arthritis," J Rheumatol, Vol.32, pp.992-997, 2005.
  51. S. Morinobu, A. Morinobu, and S. Kanagawa, "Glutathione S-transferase gene polymorphisms in Japanese patients with rheumatoid arthritis," Clin Exp Rheumatol, Vol.24, pp.268-273, 2006.
  52. A. M. Ghelani, A. Samanta, and A. C. Jones, "Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom," Rheumatol Int, Vol.31, pp.1355-1361, 2011. https://doi.org/10.1007/s00296-010-1478-2
  53. M. Hashemi, "A Possible Relationship Between Polymorphisms of Glutathione S-Transferase M1, P1 and T1 Genes and Rheumatoid Arthritis in Zahedan, Southeast Iran," Turkish Journal of Rheumatology, pp.253-257, 2012.
  54. H. Jiang, S. Wang, and G. Luo, "Relationship between the glutathione S-transferase class ${\mu}$ ($GST{\mu}$) gene deletion, oxidative injury and systemic lupus erythematosus," Chin J Rheumatol, Vol.5, pp.156-159, 2001.
  55. T. Y. Kang, A. El-Sohemy, and M. C. Comelis, "Glutathione S-transferase genotype and risk of systemic lupus erythematosus in Koreans," Lupus, Vol.14, pp.381-384, 2005. https://doi.org/10.1191/0961203305lu2100oa
  56. T. Horiuchi, M. Washio, and C. Kiyohara, "Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE: findings from the KYSS study," Rheumatology (Oxford), Vol.48, pp.1045-1049, 2009. https://doi.org/10.1093/rheumatology/kep166
  57. J. Zhang, J. Deng, and C. Zhang, "Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population," Clin Chim Acta, Vol.411, pp.878-881, 2010. https://doi.org/10.1016/j.cca.2010.03.007
  58. C. Kiyohara, M. Washio, and T. Horiuchi, "Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of cigarette smoking and systemic lupus erythematosus in a Japanese population," Scand J Rheumatol, Vol.41, pp.103-109, 2012. https://doi.org/10.3109/03009742.2011.608194
  59. Y. Rupasree, S. M. Naushad, and L. Rajasekhar, "Association of genetic variants of xenobiotic metabolic pathway with systemic lupus erythematosus," Indian J Biochem Biophys, Vol.50, pp.447-452, 2013.
  60. K. Sekine, H. Mochizuki, and Y. Inoue, "Regulation of oxidative stress in patients with Kawasaki disease," Inflammation, Vol.35, pp.952-958, 2012. https://doi.org/10.1007/s10753-011-9398-1
  61. J. Zhang, J. Deng, and C. Zhang, "Association of GSTT1, GSTM1 and CYP1A1 polymorphisms with susceptibility to systemic lupus erythematosus in the Chinese population," Clinica chimica acta; international journal of clinical chemistry, Vol.411, pp.878-881, 2010. https://doi.org/10.1016/j.cca.2010.03.007
  62. R. J. Hung, P. Boffetta, and J. Brockmoller, "CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers : a pooled analysis," Carcinogenesis, Vol.24, pp.875-882, 2003. https://doi.org/10.1093/carcin/bgg026
  63. B. Mannervik, Y. C. Awasthi, and P. G. Board, "Nomenclature for human glutathione transferases," Biochem J, Vol.282(Pt 1), pp.305-306, 1992. https://doi.org/10.1042/bj2820305
  64. T. Horiuchi, M. Washio, and C. Kiyohara, "Combination of TNF-RII, CYP1A1 and GSTM1 polymorphisms and the risk of Japanese SLE: findings from the KYSS study," Rheumatology (Oxford, England), Vol.48, pp.1045-1049, 2009. https://doi.org/10.1093/rheumatology/kep166
  65. T. Kato, H. Miyakawa, and M. Ishibashi, "Frequency and significance of anti-glutathione S-transferase autoantibody (anti-GST A1-1) in autoimmune hepatitis," J Autoimmun, Vol.22, pp.211-216, 2004. https://doi.org/10.1016/j.jaut.2004.01.003
  66. R. D. Mittal, P. K. Manchanda, and H. K. Bid, "Analysis of polymorphisms of tumor necrosis factor-alpha and polymorphic xenobiotic metabolizing enzymes in inflammatory bowel disease: study from northern India," J Gastro enterol Hepatol, Vol.22, pp.920-924, 2007. https://doi.org/10.1111/j.1440-1746.2006.04538.x
  67. Y. K. Uhm, S. H. Yoon, and I. J. Kang, "Association of glutathione S-transferase gene polymorphisms (GSTM1 and GSTT1) of vitiligo in Korean population," Life Sciences, Vol.81, pp.223-227, 2007. https://doi.org/10.1016/j.lfs.2007.05.006
  68. W. C. de Bruin, M. J. Wagenmans, and W. H. Peters, "Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract," Jpn J Cancer Res, Vol.91, pp.310-316, 2000. https://doi.org/10.1111/j.1349-7006.2000.tb00946.x
  69. A. S. Doney, S. Lee, and G. P. Leese, "Increased cardiovascular morbidity and mortality in type 2 diabetes is associated with the glutathione S transferase theta-null genotype: a Go-DARTS study," Circulation, Vol.111, pp.2927-2934, 2005. https://doi.org/10.1161/CIRCULATIONAHA.104.509224
  70. S. Landi, "Mammalian class theta GST and differential susceptibility to carcinogens: a review," Mut Res, Vol.463, pp.247-283, 2000. https://doi.org/10.1016/S1383-5742(00)00050-8
  71. I. Aguilera, I. Wichmann, and J. M. Sousa, "Antibodies against glutathione S-transferase T1 (GSTT1) in patients with de novo immune hepatitis following liver transplantation," Clin Exp immunol, Vol.126, pp.535-539, 2001. https://doi.org/10.1046/j.1365-2249.2001.01682.x
  72. P. Bohanec Grabar, D. Logar, and M. Tomsic, "Genetic polymorphisms of glutathione Stransferases and disease activity of rheumatoid arthritis," Clin Exp Rheumatol, Vol.27, pp.229-236, 2009.
  73. J. Seidegard, W. R. Vorachek, and R. W. Pero, "Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion," Proc Natl Acad Sci U S A, Vol.85, pp.7293-7297, 1998.
  74. P. A. Fraser, W. Z. Ding, and M. Mohseni, "Glutathione S-transferase M null homozygosity and risk of systemic lupus erythematosus associated with sun exposure: a possible gene-environment interaction for auto immunity," J Rheumatol, Vol.30, pp.276-282, 2003.
  75. J. M. McCord, "Free radicals and inflammation: protection of synovial fluid by superoxide dismutase," Science (New York, N.Y.), Vol.185, pp.529-531, 1974. https://doi.org/10.1126/science.185.4150.529
  76. S. Morinobu, A. Morinobu, and S. Kanagawa, "Glutathione S-transferase gene polymorphisms in Japanese patients with rheumatoid arthritis," Clin Exp Rheumatol, Vol.24, pp.268-273, 2006.
  77. H. S. Ozturk, M. Y. Cimen, and O. B. Cimen, "Oxidant/antioxidant status of plasma samples from patients with rheumatoid arthritis," Rheumatol Int, Vol.19, pp.35-37, 1999. https://doi.org/10.1007/s002960050097
  78. A. D. Ross, N. K. Banda, and M. Muggli, "Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular super oxide dismutase," Arthritis Rheum, Vol.50, pp.3702-3711, 2004. https://doi.org/10.1002/art.20593
  79. H. R. Griffiths, "Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?," Autoimm Rev, Vol.7, pp.544-549, 2008. https://doi.org/10.1016/j.autrev.2008.04.013
  80. T. R. Mikuls, T. Levan, and K. A. Gould, "Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African Americans," Arthritis Rheum, Vol.64, pp.655-664, 2012. https://doi.org/10.1002/art.33408
  81. C. Carlsten, G. S. Sagoo, and A. J. Frodsham, "Glutathione S-transferase M1 (GSTM1) polymorphisms and lung cancer: a literature-based systematic HuGE review and meta-analysis," Am J Epidemiol, Vol.167, pp.759-774, 2008. https://doi.org/10.1093/aje/kwm383
  82. L. A. Criswell, L. A. Merlino, and J. R. Cerhan, "Cigarette smoking and the risk of rheumatoid arthritis among postmenopausal women: results from the Iowa Women's Health Study," Am J Med, Vol.112, pp.465-471, 2002. https://doi.org/10.1016/S0002-9343(02)01051-3
  83. L. Lu, W. Wu, and Y. Tu, "Association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo," Gene, Vol.535, pp.12-16, 2014. https://doi.org/10.1016/j.gene.2013.11.024
  84. L. Liu, C. Li, and J. Gao, "Genetic polymorphisms of glutathione S-transferase and risk of vitiligo in the Chinese population," J Invest Dermatol, Vol.129, pp.2646-2652, 2009. https://doi.org/10.1038/jid.2009.143
  85. F. Guarneri, A. Asmundo and D. Sapienza, "Glutathione S-transferase M1/ T1 gene polymorphisms and vitiligo in a Mediterranean population," Pigment cell & melanoma research, Vol.24, pp.731-733, 2011. https://doi.org/10.1111/j.1755-148X.2011.00872.x