Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Evaluation of absorbed dose in monkey and mouse using 18F-FDG PET and CT density information

  • Kim, Wook (Division of RI-convergence Research, Korea Institute of Radiological and Medical Sciences) ;
  • Lee, Yong Jin (Division of RI-convergence Research, Korea Institute of Radiological and Medical Sciences) ;
  • Park, Yong Sung (Division of RI-convergence Research, Korea Institute of Radiological and Medical Sciences) ;
  • Cho, Doo-Wan (Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, KRICT) ;
  • Lee, Hong-Soo (Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, KRICT) ;
  • Han, Su-Cheol (Jeonbuk Department of Inhalation Research, Korea Institute of Toxicology, KRICT) ;
  • Kang, Joo Hyun (Division of RI-convergence Research, Korea Institute of Radiological and Medical Sciences) ;
  • Woo, Sang-Keun (Division of RI-convergence Research, Korea Institute of Radiological and Medical Sciences)
  • Received : 2016.11.14
  • Accepted : 2017.06.08
  • Published : 2017.06.30
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Abstract

Patient-specific image-based internal dosimetry involves using the patient's individual anatomy and spatial distribution of radioactivity over time to obtain an absorbed dose calculation. Individual absorbed dose was calculated by accumulated activity multiply S-value of each organs. The aim of this study was to calculate the S-values using Monte Carlo simulation in monkey and mouse and evaluation of absorbed dose in each organ. Self-irradiation S-value of monkey heart self-irradiation was 3.15E-03 mGy-g/MBq-s, lung self-irradiation was 8.94E-04 mGy-g/MBq-s and liver self-irradiation S-value was 2.23E-03 mGy-g/MBq-s. Mouse heart self-irradiation S-value was 1.95E-01 mGy-g/MBq-s, lung was 9.59E-02 mGy-g/MBq-s, and liver was 1.40E-03 mGy-g/MBq-s. The results of this study show that the calculation protocol of image based individual absorbed dose of each organ using Monte Carlo simulation. Therefore, this study may be applied to calculate human specific absorbed dose.

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References

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