Korean Journal of Adult Nursing (성인간호학회지)

Korean Society of Adult Nursing (한국성인간호학회)
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Change of Cancer Symptom, Depression and Quality of Life based on Phases of Chemotherapy in Patients with Colorectal or Stomach Cancer: A Prospective Study

대장암·위암 환자의 항암화학요법 시기에 따른 암 증상, 우울 및 삶의 질의 변화: 전향적 종단 연구

  • Oh, Pok Ja (Department of Nursing, Sahmyook University) ;
  • Lim, Soo Yeon (Department of Nursing, Graduate School, Sahmyook University)
  • 오복자 (삼육대학교 간호학과) ;
  • 임수연 (삼육대학교 대학원 간호학과)
  • Received : 2017.04.27
  • Accepted : 2016.06.23
  • Published : 2017.04.30
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Abstract

Purpose: The purpose of this study was to identify over time the changes of cancer symptom, depression and quality of life (QOL) among people who had stomach or colorectal cancer. Methods: Of the 74 participants recruited, 67 participated in the study. Participants were asked to complete three instruments at three different time. The instruments were the M. D. Anderson Symptom Inventory-Gastrointestinal Cancer Module, Hospital Anxiety Depression Scale, and the Functional Assessment of Cancer Therapy-General. The questionnaires were administered before chemotherapy, toward the end of chemotherapy, and six months after the completion of adjuvant therapy. Data were analyzed using descriptive statistics and repeated measure ANOVA. Results: At the immediately after chemotherapy point, the most frequent symptom was lack of appetite, followed by fatigue and problem with remembering things. The mean score for depression was 8.27 with a prevalence of 31.3%. The mean score for quality of life was 61.88 out of 135. Repeated measures ANOVA showed a significant increase in cancer symptom (F=23.22, p<.001) and depression (F=35.29, p<.001) after chemotherapy. However, improvement was observed 6 months after the completion of chemotherapy. QOL (F=33.73, p<.001) also showed similar patterns as observed with cancer symptom and depression. Cancer symptom was the strongest predictor of QoL at pre-chemotherapy point. but depression was the strongest predictor at immediately after chemotherapy point. Conclusion: Chemotherapy is highly associated with cancer symptom, depression and QOL in patients with cancer. The nursing intervention is needed to relieve depression as well as cancer symptoms to improve QOL in patients undergoing chemotherapy from baseline to follow-up.

Keywords

Acknowledgement

Supported by : 한국연구재단

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