References
- Angulo P. Nonalcoholic fatty liver disease. The New England Journal of Medicine. 2002. 346: 1221-1231. https://doi.org/10.1056/NEJMra011775
- Bataller R, Brenner DA. Liver fibrosis. Journal of Clinical Investigation. 2005. 115: 209-218. https://doi.org/10.1172/JCI24282
- Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nature Medicine. 2005. 11: 183-190. https://doi.org/10.1038/nm1166
- Canbay A, Feldstein A, Baskin-Bey E, Bronk SF, Gores GJ. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. Journal of Pharmacology and Experimental Therapeutics. 2004. 308: 1191-1196.
- Cancello R, Tordjman J, Poitou C, Guilhem G, Bouillot JL, Hugol D, Coussieu C, Basdevant A, Bar Hen A, Bedossa P, Guerre-Millo M, Clement K. Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity. Diabetes. 2006. 55: 1554-1461. https://doi.org/10.2337/db06-0133
- Cao L, Quan XB, Zeng WJ, Yang XO, Wang MJ. Mechanism of hepatocyte apoptosis. Journal of Cell Death. 2016. 9: 19-29.
- Chan W, Tan A, Vethakkan S, Tah P, Vijayananthan A, Goh K. Non-alcoholic fatty liver disease in diabetics-prevalence and predictive factors in a multiracial hospital clinic population in Malaysia. Journal of Gastroenterology and Hepatology. 2013. 28: 1375-1383. https://doi.org/10.1111/jgh.12204
- Charlton M. Nonalcoholic fatty liver disease: a review of current understanding and future impact. Clinical Gastroenterology and Hepatology. 2004. 2: 1048-1058. https://doi.org/10.1016/S1542-3565(04)00440-9
- Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki VI, Klotzsche-von Ameln A, Phieler J, Sprott D, Kanczkowski W, Tzanavari T, Bdeir M, Bergmann S, Cartellieri M, Bachmann M, Nikolakopoulou P, Androutsellis-Theotokis A, Siegert G, Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, Chavakis T. Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology. 2014. 60: 1196-1210. https://doi.org/10.1002/hep.27233
- Curat CA, Miranville A, Sengenes C, Diehl M, Tonus C, Busse R, Bouloumie A. From blood monocytes to adipose tissueresident macrophages: induction of diapedesis by human mature adipocytes. Diabetes. 2004. 53: 1285-1292. https://doi.org/10.2337/diabetes.53.5.1285
- Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006. 444: 881-887. https://doi.org/10.1038/nature05488
- Diehl AM. Hepatic complications of obesity. Gastroenterology Clinics of North America. 2005. 34: 45-61. https://doi.org/10.1016/j.gtc.2004.12.012
- Fan J. Epidemiology of alcoholic and nonalcoholic fatty liver disease in China. Journal of Gastroenterology and Hepatology. 2013. 28: 11-17.
- Feldstein AE, Canbay A, Angulo P, Taniai M, Burgart LJ, Lindor KD, Gores GJ. Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology. 2003. 125: 437-443. https://doi.org/10.1016/S0016-5085(03)00907-7
- Gomez-Lechon MJ, Donato MT, Martinez-Romero A, Jimenez N, Castell JV, O'Connor JE. A human hepatocellular in vitro model to investigate steatosis. Chemico-Biological Interactions. 2007. 165: 106-116. https://doi.org/10.1016/j.cbi.2006.11.004
- Jeong S, Chae K, Jung YS, Rho YH, Lee J, Ha J, Yoon KH, Kim GC, Oh KS, Shin SS, Yoon M. The Korean traditional medicine Gyeongshingangjeehwan inhibits obesity through the regulation of leptin and PPARalpha action in OLETF rats. Journal of Ethnopharmacology. 2008. 119: 245-251. https://doi.org/10.1016/j.jep.2008.06.037
-
Jeong S, Yoon M. Fenofibrate inhibits adipocyte hypertrophy and insulin resistance by activating adipose
$PPAR{\alpha}$ in high fat diet-induced obese mice. Experimental & Molecular Medicine. 2009. 41: 397-405. https://doi.org/10.3858/emm.2009.41.6.045 - Koh JC, Loo WM, Goh KL, Sugano K, Chan WK, Chiu WY, Choi MG, Gonlachanvit S, Lee WJ, Lee WJ, Lee YY, Lesmana LA, Li YM, Liu CJ, Matsuura B, Nakajima A, Ng EK, Sollano JD, Wong SK, Wong VW, Yang Y, Ho KY, Dan YY. Asian consensus on the relationship between obesity and gastrointestinal and liver diseases. Journal of Gastroenterology and Hepatology. 2016. 31: 1405-1413. https://doi.org/10.1111/jgh.13385
- Liang H, Zhang L, Wang H, Tang J, Yang J, Wu C, Chen S. Inhibitory effect of gardenoside on free fatty acid-induced steatosis in HepG2 hepatocytes. International Journal of Molecular Sciences. 2015. 16: 27749-27756. https://doi.org/10.3390/ijms161126058
- Machado M, Marques-Vidal P, Cortez-Pinto H. Hepatic histology in obese patients undergoing bariatric surgery. Journal of Hepatology. 2006. 45: 600-606. https://doi.org/10.1016/j.jhep.2006.06.013
- Milic S, Stimac D. Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment. Digestive Diseases. 2012. 30: 158-162. https://doi.org/10.1159/000336669
- Mulder P, Morrison MC, Wielinga PY, van Duyvenvoorde W, Kooistra T, Kleemann R. Surgical removal of inflamed epididymal white adipose tissue attenuates the development of non-alcoholic steatohepatitis in obesity. International Journal of Obesity. 2016. 40: 675-684. https://doi.org/10.1038/ijo.2015.226
- Park SH, Jeon WK, Kim SH, Kim HJ, Park DI, Cho YK, Sung IK, Sohn CI, Keum DK, Kim BI. Prevalence and risk factors of non-alcoholic fatty liver disease among Korean adults. Journal of Gastroenterology and Hepatology. 2006. 21: 138-143. https://doi.org/10.1111/j.1440-1746.2005.04086.x
- Petersen KF, Dufour S, Feng J, Befroy D, Dziura J, Dalla Man C, Cobelli C, Shulman GI. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proceedings of the National Academy of Sciences. 2006. 103: 18273 -18277. https://doi.org/10.1073/pnas.0608537103
- Roh JS, Lee H, Woo S, Yoon M, Kim J, Park SD, Shin SS, Yoon M. Herbal composition Gambigyeongsinhwan from Curcuma longa, Alnus japonica, and Massa Medicata Fermentata inhibits lipid accumulation in 3T3-L1 cells and regulates obesity in Otsuka Long-Evans Tokushima Fatty rats. Journal of Ethnopharmacology. 2015. 171: 287-294. https://doi.org/10.1016/j.jep.2015.05.056
- Saile B, Matthes N, El Armouche H, Neubauer K, Ramadori G. The bcl, NFkappaB and p53/p21WAF1 systems are involved in spontaneous apoptosis and in the anti-apoptotic effect of TGF-beta or TNF-alpha on activated hepatic stellate cells. European Journal of Cell Biology. 2001. 80: 554-561. https://doi.org/10.1078/0171-9335-00182
- Schwimmer JB, Deutsch R, Kahen T, Lavine JE, Stanley C, Behling C. Prevalence of fatty liver in children and adolescents. Pediatrics. 2006. 118: 1388-1393. https://doi.org/10.1542/peds.2006-1212
- Shin SS, Jung YS, Yoon KH, Choi S, Hong Y, Park D, Lee H, Seo BI, Lee HY, Yoon M. The Korean traditional medicine gyeongshingangjeehwan inhibits adipocyte hypertrophy and visceral adipose tissue accumulation by activating PPARalpha actions in rat white adipose tissues. Journal of Ethnopharmacology. 2010. 127: 47-54. https://doi.org/10.1016/j.jep.2009.09.052
- Tilg H, Moschen AR. Insulin resistance, inflammation, and nonalcoholic fatty liver disease. Trends in Endocrinology and Metabolism. 2008. 19: 371-379. https://doi.org/10.1016/j.tem.2008.08.005
- Van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, Kench JG, London R, Peduto T, Chisholm DJ, George J. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology. 2008. 48: 449-457. https://doi.org/10.1002/hep.22350
- Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology. 2009. 49: 306-317. https://doi.org/10.1002/hep.22603
- Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation. 2003. 112: 1821-1830. https://doi.org/10.1172/JCI200319451
- Yoon S, Kim J, Lee H, Lee H, Lim J, Yang H, Shin SS, Yoon M. The effects of herbal composition Gambigyeongsinhwan on hepatic steatosis and inflammation in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells. Journal of Ethnopharmacology. 2017. 195: 204-213. https://doi.org/10.1016/j.jep.2016.11.020
- Yu SJ, Kim W, Kim D, Yoon JH, Lee K, Kim JH, Cho EJ, Lee JH, Kim HY, Kim YJ, Kim CY. Visceral obesity predicts significant fibrosis in patients with nonalcoholic fatty liver disease. Medicine. 2015. 94: e2159. https://doi.org/10.1097/MD.0000000000002159