Abstract
Cancer is one of the most challenging human diseases. Current clinical methods have limitations for early-stage cancer diagnosis and effective therapy. Moreover, current surgical methods to remove tumors are not precise enough and chemotherapy destroys normal tissues as well as malignant tumors, resulting in severe side effects such as hair loss, vomiting, diarrhea, and blood disorders. Recently, nanotechnology using nano-sized particles suggests advanced solutions to overcome the limitations. Various nanoparticles have been reported for more accurate diagnosis and minimized side effects. However, current nanoparticles still show limited targeting accuracy for cancer generally below 5% injection dosage. Therefore, herein we report a new nanoparticle inducing device(NID) to guide the nanoparticles externally by using both variable magnetic fields and blood flows. NID can be a promising approach to improve targeting accuracy for drug delivery using iron oxide nanoparticles.
본 논문은 자석을 회전시켜 실시간으로 자기장을 변화시키고 그로 인해 특정 조건에서 산화철 나노입자를 side point(피부)보다 center point(심부)에서 더 많이 유도할 수 있다는 가능성을 제시하였다. 향후 연구로 유속에 따른 Critical Magnetic flux density, 시간에 따른 나노입자 축적량, 자기장과 산화철 나노입자의 상호작용을 고려한 실험 설계, 전자석 등을 이용한 자기장조절을 연구하여 실질적인 혈관에서 본 실험을 진행할 계획이다.