Journal of Sasang Constitutional Medicine (사상체질의학회지)

The Society Of Sasang Constitutional Medicine (사상체질의학회)
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The Effect of Phaseolus Angularis Shell on Soyang-in Metabolic Syndrome with Obesity

적소두(赤小豆) 외피(外皮)(Phaseolus angularis shell)의 고지방식이로 유도된 비만 동물모델에서 항비만, 항고지혈증 효과

  • Kwak, Jin-young (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Daejeon University) ;
  • Park, Jung-Hwan (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Daejeon University) ;
  • Koh, Young-mee (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Daejeon University) ;
  • Park, Jung-mi (Cheonan Hospital Wellness Clinical Center of Daejeon University) ;
  • Ahn, Taek-Won (Dept. of Sasang Constitutional Medicine, College of Korean Medicine, Daejeon University)
  • 곽진영 (대전대학교 한의과대학 사상체질의학교실) ;
  • 박정환 (대전대학교 한의과대학 사상체질의학교실) ;
  • 고영미 (대전대학교 한의과대학 사상체질의학교실) ;
  • 박정미 (대전대학교 천안한방병원 웰니스임상센터) ;
  • 안택원 (대전대학교 한의과대학 사상체질의학교실)
  • Received : 2017.05.29
  • Accepted : 2017.06.16
  • Published : 2017.06.30
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Abstract

Objectives This experimental study was designed to investigate the effect of Phaseolus angularis shell on metabolic syndrome. Methods Each 5 C57BL/6J mice were randomly assigned to normal diet group, high-fat diet(HFD) control group, high-fat diet plus 15.6 mg/kg/day of Orlistat(HFD-Orlistat) group, high-fat diet plus 100mg/kg/day of Phaseolus angularis shell extract(HFD-PAS_E) group. Weight, the blood chemical and hematologic parameter was med. The mRNA expression was assayed through Reverse transcriptase polymerase chain reaction(RT-PCR). Results In HFD-PAS_E group, the body weight gain, weight of liver, and the level of LDL-Cholesterol were significantly decreased and the level of HDL-Cholesterol were significantly increased. The size of adipocyte in HFD-PAS_E group was smaller than HFD group's. In HFD-PAS_E group, the expression of leptin, PPAR-${\gamma}$, AP2/FABP4 mRNA in liver adipocyte tissue was decreased, the expression of Adiponectin, UCP-2 mRNA in liver adipocyte tissue was increased and the expression of Leptin, C/EBP-a, AP2/FABP4 mRNA in epididymal adipocyte tissue was decreased. Conclusion These results suggest that Phaseolus angularis shell has inhibitory effects on metabolic syndrome by reducing the body weight and the levels of lipid contents in high-fat-diet induced obese mice.

Keywords

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