Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
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Clinicopathological Features and Survival of Patients with Gastric Cancer with a Family History: a Large Analysis of 2,736 Patients with Gastric Cancer

  • Jeong, Oh (Division of Gastroenterological Surgery, Department of Surgery, Chonnam National University School of Medicine) ;
  • Jung, Mi Ran (Division of Gastroenterological Surgery, Department of Surgery, Chonnam National University School of Medicine) ;
  • Park, Young Kyu (Division of Gastroenterological Surgery, Department of Surgery, Chonnam National University School of Medicine) ;
  • Ryu, Seong Yeob (Division of Gastroenterological Surgery, Department of Surgery, Chonnam National University School of Medicine)
  • Received : 2017.04.13
  • Accepted : 2017.06.02
  • Published : 2017.06.30
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Abstract

Purpose: Previous studies indicated conflicting results regarding the prognosis of gastric cancer with a family history (FHX). This study aimed to determine the clinicopathological features and survival of patients with gastric cancer with a FHX. Materials and Methods: We reviewed 2,736 patients with gastric cancer who underwent surgery between 2003 and 2009. The prognostic value of a FHX was determined in the multivariate model after adjusting for variables in the Asian and internationally validated prognostic models. Results: Of the patients, 413 (15.1%) had a FHX of gastric cancer. The patients with a FHX were younger (58.1 vs. 60.4 years; P<0.001) than the patients without a FHX. There were no significant differences in the histopathological characteristics between the 2 groups. A FHX was associated with a better overall survival (OS) rate only in the stage I group (5-year survival rate, 95% vs. 92%; P=0.006). However, the disease-specific survival (DSS) rate was not significantly different between the 2 groups in all stages. The multivariate model adjusted for the variables in the Asian and internationally validated prognostic models revealed that FHX has no significant prognostic value for OS and DSS. Conclusions: The clinicopathological features and survival of the patients with gastric cancer with a FHX did not significantly differ from those of the patients without a FHX.

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References

  1. Parkin DM, Ferlay J, Curado MP, Bray F, Edwards B, Shin HR, et al. Fifty years of cancer incidence: CI5 I-IX. Int J Cancer 2010;127:2918-2927. https://doi.org/10.1002/ijc.25517
  2. Huang JQ, Sridhar S, Chen Y, Hunt RH. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 1998;114:1169-1179. https://doi.org/10.1016/S0016-5085(98)70422-6
  3. Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer 2007;10:75-83. https://doi.org/10.1007/s10120-007-0420-0
  4. Setia N, Clark JW, Duda DG, Hong TS, Kwak EL, Mullen JT, et al. Familial gastric cancers. Oncologist 2015;20:1365-1377. https://doi.org/10.1634/theoncologist.2015-0205
  5. Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol 2006;12:354-362. https://doi.org/10.3748/wjg.v12.i3.354
  6. Yatsuya H, Toyoshima H, Mizoue T, Kondo T, Tamakoshi K, Hori Y, et al. Family history and the risk of stomach cancer death in Japan: differences by age and gender. Int J Cancer 2002;97:688-694. https://doi.org/10.1002/ijc.10101
  7. Yaghoobi M, Bijarchi R, Narod SA. Family history and the risk of gastric cancer. Br J Cancer 2010;102:237-242. https://doi.org/10.1038/sj.bjc.6605380
  8. Shin CM, Kim N, Lee HS, Lee DH, Kim JS, Jung HC, et al. Intrafamilial aggregation of gastric cancer: a comprehensive approach including environmental factors, Helicobacter pylori virulence, and genetic susceptibility. Eur J Gastroenterol Hepatol 2011;23:411-417. https://doi.org/10.1097/MEG.0b013e328343b7f5
  9. Ebert MP, Malfertheiner P. Pathogenesis of sporadic and familial gastric cancer--implications for clinical management and cancer prevention. Aliment Pharmacol Ther 2002;16:1059-1066. https://doi.org/10.1046/j.1365-2036.2002.01288.x
  10. Palli D, Russo A, Saieva C, Salvini S, Amorosi A, Decarli A. Dietary and familial determinants of 10-year survival among patients with gastric carcinoma. Cancer 2000;89:1205-1213. https://doi.org/10.1002/1097-0142(20000915)89:6<1205::AID-CNCR3>3.0.CO;2-5
  11. Gao Y, Hu N, Han X, Giffen C, Ding T, Goldstein A, et al. Family history of cancer and risk for esophageal and gastric cancer in Shanxi, China. BMC Cancer 2009;9:269-279. https://doi.org/10.1186/1471-2407-9-269
  12. Lee WJ, Hong RL, Lai IR, Chen CN, Lee PH, Huang MT. Clinicopathologic characteristics and prognoses of gastric cancer in patients with a positive familial history of cancer. J Clin Gastroenterol 2003;36:30-33. https://doi.org/10.1097/00004836-200301000-00010
  13. Han MA, Oh MG, Choi IJ, Park SR, Ryu KW, Nam BH, et al. Association of family history with cancer recurrence and survival in patients with gastric cancer. J Clin Oncol 2012;30:701-708. https://doi.org/10.1200/JCO.2011.35.3078
  14. Sobin LH, Gospodarowicz MK, Wittekind C. TNM Classification of Malignant Tumours. New York (NY): John Wiley & Sons, 2011.
  15. Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer 2011;14:113-123. https://doi.org/10.1007/s10120-011-0042-4
  16. Woo Y, Son T, Song K, Okumura N, Hu Y, Cho GS, et al. A novel prediction model of prognosis after gastrectomy for gastric carcinoma: development and validation using Asian databases. Ann Surg 2016;264:114-120. https://doi.org/10.1097/SLA.0000000000001523
  17. Kattan MW, Karpeh MS, Mazumdar M, Brennan MF. Postoperative nomogram for disease-specific survival after an R0 resection for gastric carcinoma. J Clin Oncol 2003;21:3647-3650. https://doi.org/10.1200/JCO.2003.01.240
  18. Fang WL, Chang SC, Lan YT, Huang KH, Lo SS, Li AF, et al. Molecular and survival differences between familial and sporadic gastric cancers. Biomed Res Int 2013;2013:396272.
  19. Hemminki K, Sundquist J, Ji J. Is family history associated with improved survival in patients with gastric cancer? J Clin Oncol 2012;30:3150-3151.
  20. Kanemitsu K, Kawasaki K, Nakamura M, Li D, Yasuda T, Kuroda D, et al. MSI is frequently recognized among gastric cancer patients with a family history of cancer. Hepatogastroenterology 2007;54:2410-2414.
  21. Pedrazzani C, Corso G, Velho S, Leite M, Pascale V, Bettarini F, et al. Evidence of tumor microsatellite instability in gastric cancer with familial aggregation. Fam Cancer 2009;8:215-220. https://doi.org/10.1007/s10689-008-9231-7
  22. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003;124:1193-1201. https://doi.org/10.1016/S0016-5085(03)00157-4
  23. Brenner H, Bode G, Boeing H. Helicobacter pylori infection among offspring of patients with stomach cancer. Gastroenterology 2000;118:31-35. https://doi.org/10.1016/S0016-5085(00)70411-2
  24. Ebert MP, Yu J, Miehlke S, Fei G, Lendeckel U, Ridwelski K, et al. Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer. Br J Cancer 2000;82:1795-1800. https://doi.org/10.1054/bjoc.1999.1107
  25. Kluijt I, Sijmons RH, Hoogerbrugge N, Plukker JT, de Jong D, van Krieken JH, et al. Familial gastric cancer: guidelines for diagnosis, treatment and periodic surveillance. Fam Cancer 2012;11:363-369. https://doi.org/10.1007/s10689-012-9521-y
  26. Shinmura K, Kohno T, Takahashi M, Sasaki A, Ochiai A, Guilford P, et al. Familial gastric cancer: clinicopathological characteristics, RER phenotype and germline p53 and E-cadherin mutations. Carcinogenesis 1999;20:1127-1131. https://doi.org/10.1093/carcin/20.6.1127
  27. Kim SJ, Cho SJ, Heo SC, Yang HK, Kim WH, Park JG, et al. The incidence of hereditary gastric cancer in Korean. J Korean Cancer Assoc 2000;32:1-6.
  28. Kerber RA, Slattery ML. Comparison of self-reported and database-linked family history of cancer data in a case-control study. Am J Epidemiol 1997;146:244-248. https://doi.org/10.1093/oxfordjournals.aje.a009259

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