한국동물위생학회지 (Korean Journal of Veterinary Service)

  • 제40권2호
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  • Pages.143-147
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  • 2017
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  • 3022-7372(pISSN)
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  • 2287-7630(eISSN)
한국동물위생학회 (The Korean Society of Veterinary Service)
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Phenobarbital and zonisamide treatment of a cat with epilepsy of unknown cause

  • Lee, Ki-Ho (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Park, Jun-Seok (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Jung-Kook (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Seo, Kyoung-Won (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-Ho (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University)
  • 투고 : 2017.04.26
  • 심사 : 2017.06.23
  • 발행 : 2017.06.30
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초록

A Korean domestic short hair (1-year-old, male) presented with 2 to 3 weeks of seizures, aggressive behavior, vomiting, anorexia, and lethargy. The frequency of seizure had gradually increased from once a week to once every 3 hours. Physical and neurologic examination, diagnostic screening tests, including complete blood count (CBC), serum chemistry, electrolyte, coagulation test, X-ray, ultrasonography, and urinalysis were performed. Feline Leukemia Virus (FeLV), Feline Immunodeficiency Virus (FIV) and Toxoplasma spp. All tested negative, but the Feline Corona Virus (FCoV) kit revealed a positive result. To determine the exact diagnosis, magnetic resonance imaging (MRI) was performed but yielded no specific findings. The patient was then diagnosed with idiopathic epilepsy and treatment of phenobarbital was initiated. A month's treatment with phenobarbital proved ineffective as symptoms worsened. Zonisamide was then selected as an additional anticonvulsant. After adding zonisamide, symptoms improved, and seizures abated for 15 months. This is the first case report in South Korea describing the use of phenobarbital and zonisamide in the treatment of a cat with idiopathic epilepsy.

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참고문헌

  1. Bailey KS, Dewey CW. 2009. The Seizuring Cat Diagnostic Work-Up and Therapy. J Feline Med Surg 11: 385-394. https://doi.org/10.1016/j.jfms.2009.03.006
  2. Berg AT, Berkovic SF, Brodie MJ, Buchhalter J, Cross JH, van Emde BW, Engel J, French J, Glauser TA, Mathern GW, Moshe SL, Nordli D, Plouin P, Scheffer IE. 2010. Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia 51: 676-685. https://doi.org/10.1111/j.1528-1167.2010.02522.x
  3. Christopher LM. 2013. Terminology and classification of seizures and epilepsy in veterinary patients. Top Companion Anim Med 28: 34-41. https://doi.org/10.1053/j.tcam.2013.06.008
  4. Hasegawa D, Kobayashi M, Kuwabara T, Ohmura T, Fujita M, Orima H. 2008. Pharmacokinetics and toxicity of zonisamide in cats. J Feline Med Surg 10: 418-421. https://doi.org/10.1016/j.jfms.2008.01.006
  5. Kuwabara T, Hasegawa D, Ogawa F, Kobayashi M, Fujita M, Suzuki H, Matsuki N, Orima H. 2010. A familial spontaneous epileptic feline strain: a novel model of idiopathic/genetic epilepsy. Epilepsy Res 92: 85-88. https://doi.org/10.1016/j.eplepsyres.2010.08.010
  6. Little SE. 2012. The cat: clinical medicine and management. Elsevier Health Sciences. pp. 1038-1047.
  7. Muñana KR. 2013. Management of refractory epilepsy. Top Companion Anim Med 28: 67-71. https://doi.org/10.1053/j.tcam.2013.06.007
  8. Pakozdy A, Leschnik M, Sarchahi AA, Tichy AG, Thalhammer JG. 2010. Clinical comparison of primary versus secondary epilepsy in 125 cats. J Feline Med Surg 12: 910-916. https://doi.org/10.1016/j.jfms.2010.07.001
  9. Pakozdy A, Sarchahi AA, Leschnik M, Tichy AG, Halasz P, Thalhammer JG. 2013. Treatment and long-term follow-up of cats with suspected primary epilepsy. J Feline Med Surg 15: 267-273. https://doi.org/10.1177/1098612X12464627
  10. Plumb DC. 2015. Plumb's veterinary drug handbook. pp. 1143-1147. 8th ed. Wiley-Blackwell, Ames.
  11. Rusbridge C. 2005. Diagnosis and control of epilepsy in the cat. In Practice 27: 208-214. https://doi.org/10.1136/inpract.27.4.208
  12. Schriefl S, Steinberg TA, Matiasek K, Ossig A, Fenske N, Fischer A. 2008. Etiologic classification of seizures, signalment, clinical signs, and outcome in cats with seizure disorders: 91 cases (2000-2004). J Am Vet Med Assoc 233: 1591-1597. https://doi.org/10.2460/javma.233.10.1591
  13. Wahle AM, Bruhschwein A, Matiasek K, Putschbach K, Wagner E, Mueller RS, Fischer A. 2014. Clinical characterization of epilepsy of unknown cause in cats. J Vet Intern Med 28: 182-188. https://doi.org/10.1111/jvim.12250