Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Chemical Constituents from the Apical Bud of Gardenia sootepensis and Their Bioactivity

Gardenia sootepensis의 끝눈으로부터 생리활성 성분

  • Youn, Ui Joung (Division of Life Sciences, Korea Polar Research Institute, KIOST) ;
  • Chang, Leng Chee (Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo)
  • 윤의중 (극지연구소 극지생명과학 연구부) ;
  • 장영기 (하와이 주립대학교 약학대학 약학과)
  • Received : 2017.05.24
  • Accepted : 2017.06.15
  • Published : 2017.06.30
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Abstract

Bioassay guided fractionation and isolation of the $CH_2Cl_2$ extract from the apical bud of Gardenia sootepensis (Rubiaceae) led to the isolation of five known flavonoids (1-5). The structures of the compounds were determined by 1D and 2D NMR, and MS experiments, as well as by comparison of their data with published values. Compounds 1-5 were isolated for the first time from this plant source. The isolated compounds were evaluated for their cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production. Among the isolates, compound 4 exhibited considerable NO inhibitory activity with an $IC_{50}$ value of $13.8{\mu}M$.

Keywords

References

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