Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Triterpenes with Inhibitory Effects of Nitric Oxide Production from the Fruit Galls of Actinidia polygama on LPS-Induced RAW264.7 and BV2 Cells

목천료의 RAW264.7과 BV2 세포주에서의 일산화질소 생성 억제효과 트리테르펜

  • Li, Xiao Jun (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Kwan-Woo (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Ko, Wonmin (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Dong-Cheol (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Yoon, Chi-Su (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Liu, Xiang Qian (School of Pharmacy, Hunan University of Chinese Medicine) ;
  • Oh, Hyuncheol (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University) ;
  • Kim, Youn-Chul (Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University)
  • 리소군 (원광대학교 약학대학 약품연구소) ;
  • 김관우 (원광대학교 약학대학 약품연구소) ;
  • 고원민 (원광대학교 약학대학 약품연구소) ;
  • 김동철 (원광대학교 약학대학 약품연구소) ;
  • 윤치수 (원광대학교 약학대학 약품연구소) ;
  • 유향전 (후난중의약대학) ;
  • 오현철 (원광대학교 약학대학 약품연구소) ;
  • 김윤철 (원광대학교 약학대학 약품연구소)
  • Received : 2016.06.09
  • Accepted : 2017.03.03
  • Published : 2017.06.30
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Abstract

To isolate and identify the constituents of the fruit galls of Actinidium polygama as well as evaluate the anti-inflammatory effects of the isolated compounds, a total of five triterpenes were isolated including $2{\alpha},3{\alpha},24$-trihydroxy-12-ursene-23-al-28-oic acid (1), corosolic acid (2), $2{\alpha},3{\alpha},24$-trihydroxyurs-12,20(30)-dien-28-oic acid (3), $2{\alpha},3{\alpha},24$-trihydroxyolean-12-en-28-oic acid (4), and $2{\alpha},3{\alpha},24$-trihydroxyurs-12-en-28-oic acid (pygenic acid B) (5). Compounds 1, 3, and 4 were isolated from the fruit galls of A. polygama for the first time. Compound 3 decreased NO production in LPS-stimulated RAW264.7 macrophages and mouse microglia BV2 cells in a concentration-dependent manner.

Keywords

References

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