Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Neolignan Derivatives from the Flower of Magnolia biondii Pamp. and their Effects on IL-2 expression in T-cells

  • Nguyen, Thi Tuyet Mai (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) ;
  • Nguyen, Thi Thu (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University) ;
  • Lee, Hyun-Su (School of Life Sciences, Immune Synapse Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology) ;
  • Jun, Chang-Duk (School of Life Sciences, Immune Synapse Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology) ;
  • Min, Byung Sun (College of Pharmacy, Drug Research and Development Center, Catholic University of Daegu) ;
  • Kim, Jeong Ah (College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University)
  • Received : 2017.01.06
  • Accepted : 2017.04.03
  • Published : 2017.06.30
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Abstract

The isolation of the MeOH extract from the flower bud of Magnolia biondii Pamp. using various column chromatographies and HPLC led to eleven neoglignan derivatives (1 - 11). Their structures were mainly determined by 1D and 2D NMR spectral data analysis and physiological methods. The isolated compounds (1 - 11) were tested for anti-allergic effects using IL-2 inhibitory assay in Jurkat T cells.

Keywords

References

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