Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지
DOI QR코드

DOI QR Code

Evaluation of Hemostatic Function with Thromboelastography in Dogs with Hypercoagulable Diseases

  • Kim, Ja-Won (College of Veterinary Medicine, Chungnam National University) ;
  • Nam, Aryung (College of Veterinary Medicine, Seoul National University) ;
  • Lee, Kyu-Pil (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-Ho (College of Veterinary Medicine, Chungnam National University) ;
  • Youn, Hwa-Young (College of Veterinary Medicine, Seoul National University) ;
  • Seo, Kyoung-Won (College of Veterinary Medicine, Chungnam National University)
  • Received : 2017.01.22
  • Accepted : 2017.03.28
  • Published : 2017.04.28
Download PDF
⟨ Previous Next ⟩

Abstract

Thromboembolic complications are increasing in veterinary medicine. Thromboelastography (TEG) is a more comprehensive method for assessing the clotting process than standard plasma-based coagulation tests. This study compared the ability of TEG and standard coagulation tests to analyze the overall hemostatic state of dogs. The study involved 40 dogs with underlying diseases that predispose to hypercoagulability, including neoplasia, hyperadrenocorticism, immune-mediated diseases, gastrointestinal diseases, and protein-losing nephropathies and enteropathies, and 20 healthy dogs. Their overall hemostatic functional state was evaluated by TEG and routine coagulation assays, including activated partial thromboplastin time, prothrombin time, platelet count, and D-dimer concentration. TEG analysis showed significant differences in clot formation time, ${\alpha}$ angle, and maximum amplitude (MA) between diseased and control dogs (P < 0.001 each). Increased MA was the most frequent abnormality on TEG and was indicative of hypercoagulability. TEG was useful in detecting hemostatic dysfunction in dogs with diseases associated with hypercoagulability. Dogs with TEG tracings indicative of hypercoagulability are likely to be in procoagulant states. Future prospective studies are needed to evaluate whether TEG tracings indicative of hypercoagulability are predictive of thrombosis in dogs.

Keywords

References

  1. Bauer, Natali B, Eralp O, Moritz A. Effect of hemolysis on canine kaolin-activated thromboelastography values and ADVIA 2120 platelet activation indices. Vet Clin Pathol 2010; 39: 180-189. https://doi.org/10.1111/j.1939-165X.2010.00224.x
  2. Dai Y, Lee A, Critchley LA, White PF. Does thromboelastography predict postoperative thromboembolic events? A systematic review of the literature. Anesth Analg 2009; 108: 734-742. https://doi.org/10.1213/ane.0b013e31818f8907
  3. Donahue, Suzanne M, Brooks M, Otto CM. Examination of hemostatic parameters to detect hypercoagulability in dogs with severe protein-losing nephropathy. J Vet Emerg Crit Care 2011; 21: 346-355. https://doi.org/10.1111/j.1476-4431.2011.00656.x
  4. Donahue Suzanne M, Otto CM. Thromboelastography: a tool for measuring hypercoagulability, hypocoagulability, and fibrinolysis. J Vet Emerg Crit Care 2005; 15: 9-16. https://doi.org/10.1111/j.1476-4431.2005.04025.x
  5. Goodwin L, Goggs R, Chan D, Allenspach K. Hypercoagulability in dogs with protein-losing enteropathy. J Vet Intern Med 2011; 25: 273-277. https://doi.org/10.1111/j.1939-1676.2011.0683.x
  6. Koenigshof AM, Scott MA, Brown AJ. Effects of delayed anticoagulation and use of evacuated tubes on non-activated thrombelastography in dogs. Vet Clin Pathol 2012; 41: 63-70. https://doi.org/10.1111/j.1939-165X.2011.00387.x
  7. Kol A, Nelson R, Gosselin R, Borjesson D. Characterization of thrombelastography over time in dogs with hyperadrenocorticism. Vet J 2013; 197: 675-681. https://doi.org/10.1016/j.tvjl.2013.05.047
  8. Kristensen AT, Wiinberg B, Jessen LR, Andreasen E, Jensen AL. Evaluation of human recombinant tissue factor-activated thromboelastography in 49 dogs with neoplasia. J Vet Intern Med 2008; 22: 140-147. https://doi.org/10.1111/j.1939-1676.2008.0030.x
  9. Lennon E, Hanel R, Walker J, Vaden S. Hypercoagulability in dogs with protein-losing nephropathy as assessed by thromboelastography. J Vet Intern Med 2013; 27: 462-468. https://doi.org/10.1111/jvim.12067
  10. Mallett SV, Cox DJ. Thromboelastography. Brit J Anaesth 1992; 69: 307-313. https://doi.org/10.1093/bja/69.3.307
  11. Sinnott VB, Otto CM. Use of thromboelastography in dogs with immune-mediated hemolytic anemia: 39 cases (2000-2008). J Vet Emerg Crit Care 2009; 19: 484-488. https://doi.org/10.1111/j.1476-4431.2009.00455.x
  12. Trapani LM. Thromboelastography: current applications, future directions. Open J Anesthesiol 2013; 3: 23-27 https://doi.org/10.4236/ojanes.2013.31007
  13. Wagg CR, Boysen SR, Bedard C. Thrombelastography in dogs admitted to an intensive care unit. Vet Clin Pathol 2009; 38: 453-461. https://doi.org/10.1111/j.1939-165X.2009.00161.x
  14. Wiinberg B, Jensen AL, Johansson P, Rozanski E, Tranholm M, Kristensen AT. Thromboelastographic evaluation of hemostatic function in dogs with disseminated intravascular coagulation. J Vet Intern Med 2008; 22: 357-365. https://doi.org/10.1111/j.1939-1676.2008.0058.x

Cited by

  1. Thrombin Generation Assay and Hemostatic Profile for Elucidating Hypercoagulability in Endogenous Canine Hyperadrenocorticism vol.45, pp.None, 2017, https://doi.org/10.1016/j.tcam.2021.100581