Biomolecules & Therapeutics

  • 제25권4호
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  • Pages.374-382
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  • 2017
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
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Sex Differences in Autism-Like Behavioral Phenotypes and Postsynaptic Receptors Expression in the Prefrontal Cortex of TERT Transgenic Mice

  • Kim, Ki Chan (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Cho, Kyu Suk (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Yang, Sung Min (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Gonzales, Edson Luck (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Valencia, Schley (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Eun, Pyeong Hwa (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Choi, Chang Soon (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Mabunga, Darine Froy (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Kim, Ji-Woon (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Noh, Judy Kyoungju (College of Human Ecology, Cornell University) ;
  • Kim, Hee Jin (Uimyung Research Institute for Neuroscience, School of Pharmacy, Sahmyook University) ;
  • Jeon, Se Jin (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Han, Seol-Heui (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University) ;
  • Bahn, Geon Ho (Department of Neuropsychiatry, School of Medicine, Kyung Hee University) ;
  • Shin, Chan Young (Center for Neuroscience Research, SMART Institute of Advanced Biomedical Sciences, Konkuk University)
  • 투고 : 2016.11.01
  • 심사 : 2016.12.06
  • 발행 : 2017.07.01
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초록

Autism spectrum disorder (ASD) remains unexplained and untreated despite the high attention of research in recent years. Aside from its various characteristics is the baffling male preponderance over the female population. Using a validated animal model of ASD which is the telomerase reverse transcriptase overexpressing mice (TERT-tg), we conducted ASD-related behavioral assessments and protein expression experiments to mark the difference between male and females of this animal model. After statistically analyzing the results, we found significant effects of TERT overexpression in sociability, social novelty preference, anxiety, nest building, and electroseizure threshold in the males but not their female littermates. Along these differences are the male-specific increased expressions of postsynaptic proteins which are the NMDA and AMPA receptors in the prefrontal cortex. The vGluT1 presynaptic proteins, but not GAD, were upregulated in both sexes of TERT-tg mice, although it is more significantly pronounced in the male group. Here, we confirmed that the behavioral effect of TERT overexpression in mice was male-specific, suggesting that the aberration of this gene and its downstream pathways preferentially affect the functional development of the male brain, consistent with the male preponderance in ASD.

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