Biomolecules & Therapeutics

  • 제25권4호
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  • Pages.345-353
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  • 2017
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  • 1976-9148(pISSN)
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  • 2005-4483(eISSN)
한국응용약물학회 (The Korean Society of Applied Pharmacology)
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Production of Recombinant Anti-Cancer Vaccines in Plants

  • Lee, Jeong Hwan (Department of Medicine, Therapeutic Protein Engineering Lab, College of Medicine, Chung-Ang University) ;
  • Ko, Kisung (Department of Medicine, Therapeutic Protein Engineering Lab, College of Medicine, Chung-Ang University)
  • 투고 : 2016.06.13
  • 심사 : 2017.02.06
  • 발행 : 2017.07.01
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초록

Plant expression systems have been developed to produce anti-cancer vaccines. Plants have several advantages as bioreactors for the production of subunit vaccines: they are considered safe, and may be used to produce recombinant proteins at low production cost. However, several technical issues hinder large-scale production of anti-cancer vaccines in plants. The present review covers design strategies to enhance the immunogenicity and therapeutic potency of anti-cancer vaccines, methods to increase vaccine-expressing plant biomass, and challenges facing the production of anti-cancer vaccines in plants. Specifically, the issues such as low expression levels and plant-specific glycosylation are described, along with their potential solutions.

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참고문헌

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