International Journal of Oral Biology

The Korean Academy of Oral Biology (대한구강생물학회)
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Effect of Metformin on Cell Growth and Differentiation in Cultured Odontoblasts

  • Oh, Chang Young (Oral Biology Research Institute, School of Dentistry, Chosun University) ;
  • Kim, Su-Gwan (Oral Biology Research Institute, School of Dentistry, Chosun University) ;
  • Go, Dae-San (Oral Biology Research Institute, School of Dentistry, Chosun University) ;
  • Yu, Sun-Kyoung (Oral Biology Research Institute, School of Dentistry, Chosun University) ;
  • Kim, Tae-Hoon (Oral Biology Research Institute, School of Dentistry, Chosun University) ;
  • Kim, Chun Sung (Oral Biology Research Institute, School of Dentistry, Chosun University) ;
  • Park, Joo-Cheol (Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University) ;
  • Kim, Do Kyung (Oral Biology Research Institute, School of Dentistry, Chosun University)
  • Received : 2017.04.26
  • Accepted : 2017.05.23
  • Published : 2017.06.30
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Abstract

Metformin (1,1-dimethylbiguanide hydrochloride), derived from French lilac (Galega officinalis), is a first-line anti-diabetic drug prescribed for patients with type 2 diabetes. However, the role of metformin in odontoblastic cell differentiation is still unclear. This study therefore undertook to examine the effect of metformin on regulating odontoblast differentiation in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. As compared to controls, metformin significantly accelerated the mineralization, significantly increased and accelerated the expressions of ALP and Col I mRNAs, and significantly increased the accelerated expressions of DSPP and DMP-1 mRNAs, during differentiation of MDPC-23 cells. There was no alteration in cell proliferation of MDPC-23 cells, on exposure to metformin. These results suggest that the effect of metformin on MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells, facilitates the odontoblast differentiation and mineralization, without altering the cell proliferation.

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References

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