DOI QR코드

DOI QR Code

Pilot Study on Anti-wrinkle Effect of Herbal Cosmetic Containing the Extracts of Douchi (fermented Glycine max Merr.)

두시 추출물을 함유한 한방화장품의 주름개선 효과에 대한 예비 임상연구

  • Kim, Hee Yeon (Department of Korean Pediatrics, Korean Medicine Hospital, Pusan National University) ;
  • Cha, Ho Yeol (Department of Korean Pediatrics, Korean Medicine Hospital, Pusan National University) ;
  • Ha, Kitae (School of Korean Medicine, Pusan National University) ;
  • Choi, Jun Yong (School of Korean Medicine, Pusan National University) ;
  • Chen, Jin Hong (Department of Korean Pediatrics, Korean Medicine Hospital, Pusan National University) ;
  • Kim, Kibong (Department of Korean Pediatrics, Korean Medicine Hospital, Pusan National University)
  • 김희연 (부산대학교한방병원 한방소아과) ;
  • 차호열 (부산대학교한방병원 한방소아과) ;
  • 하기태 (부산대학교 한의학전문대학원) ;
  • 최준용 (부산대학교 한의학전문대학원) ;
  • 천진홍 (부산대학교한방병원 한방소아과) ;
  • 김기봉 (부산대학교한방병원 한방소아과)
  • Received : 2017.11.21
  • Accepted : 2017.12.19
  • Published : 2017.12.25

Abstract

From March 1, 2017 to May 31, 2017, subjects were allowed to apply a wrinkle-improving herbal cosmetic product containing the extract of Douchi for 8 weeks. The effectiveness of herbal cosmetics was evaluated through wrinkle improvement efficacy parameter analysis, subjective wrinkle improvement through questionnaires, and adverse reaction. The herbal cosmetic products containing the extract of Douchi showed a significant decrease in the wrinkle improvement efficacy parameter analysis result. The results of the subjective satisfaction analysis after use were also evaluated positively. We could confirm the possibility of wrinkle improvement effect of Douchi extract, and it will be possible to contribute to the expansion of korean medicine field through more studies in the future.

Keywords

References

  1. Forslind B. A domain mosaic model of the skin barrier. Acta Derm Venereol. 1994;74(1):1-6.
  2. Gilchrest BA. Skin aging and photoaging: an overview. J Am Acad Dermatol. 1989;21(3 Pt2):610-3. https://doi.org/10.1016/S0190-9622(89)70227-9
  3. Society KD. Dermatology. 4th ed. Seoul: Yeomoongak; 2001. p. 3-5.
  4. Uitto J. Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatol Clin. 1986;4(3):433-46. https://doi.org/10.1016/S0733-8635(18)30806-4
  5. Favier AE, Cadet J, Kalyanaraman B, Fontecave M, Pierre JL. Analysis of free radicals in biological system. 1st ed. Basel: Birkhauser Verlag; 1995. p. 21-36.
  6. Rice-Evans CA, Burdon RH. Free Radical Damage and its Control. 1st ed. Amsterdam: Elsevier science; 1994. p. 133-9.
  7. Favier AE, Cadet J, Kalyanaraman B, Fontecave M, Pierre JL. Analysis of Free Radicals in Biological Systems. 1st ed. Basel: Birkhauser Verlag; 1995. p. 37-50.
  8. Maeda K, Fukuda M. In vitro effectiveness of several whitening cosmetic components in human melanocytes. J Soc Cosmet Chem. 1991;42(6):361-8.
  9. Seo SJ, Kong MR, Joo EY. Anti-aging and Antioxidant Activities of Extracts from Liriope platyphylla Fruits. J Invest Cosmetol. 2013;9(2):105-14. https://doi.org/10.15810/jic.2013.9.2.004
  10. Jang MJ, Jun DH, Kim SH, Han SI, Lee JT. Anti-Wrinkle Effect of Chestnut Leaf. J Life Sci. 2013;23(6):751-6. https://doi.org/10.5352/JLS.2013.23.6.751
  11. Kim HJ, Seo SJ, Kim NW. Antioxidant and Anti-wrinkling Activitiesof Water and Ethanol Extracts from the Aerial Parts of Vicia amoena. J Invest Cosmetol. 2015;11(4):285-92. https://doi.org/10.15810/jic.2015.11.4.001
  12. Lee JN, Kim SW, Yoo YK, Lee GT, Lee KK. Anti-wrinkle Effect of Morinda citrifolia (Noni) Extracts. J Soc Cosmet Scientists Korea. 2006;32(4):227-31.
  13. Youn JS, Shin SY, Wu YX, Hwang JY, Cho JH, Ha YG, et al. Antioxidant and Anti-wrinkling Effects of Aruncus dioicus var. kamtschaticus extract. Korean J Food Preserv. 2012;19(3):393-9. https://doi.org/10.11002/kjfp.2012.19.3.393
  14. Yang WS, Kim YM, Kim EH, Seu YB, Tang YJ, Kim HW et al. Anti-wrinkle Effect of Cosmetics Containing Duchesnea indica Extract. J Soc Cosmet Scientists Korea. 2010;36(4):281-8.
  15. Lee YE, Lee HJ, Kim JS. The Anti-wrinkle Effects of Cultivated Wild Ginseng Pharmacopuncture. J Acupunct Res. 2015;32(2):97-103.
  16. Han MR, Kim NW, Lee YS. Anti-wrinkle and Antioxidative Effects of Ethanolic Extracts of Inula Flos, Chrysanthemi Flos and Carthami Flos. J Invest Cosmetol. 2013;9(4):361-9.
  17. Jung HJ, Do EJ, Lee JS, Park HJ, Oh GS, Kim MR et al. A Clinical Research about Herbal Cosmetics Containing Momordica charntia L. Extracts on the Anti-wrinkle and Whitening Effects. J Korean Orient Med Ophthalmol Otolaryngol Dermato. 2011;24(2):68-78.
  18. Song JH, Ahn SH, Cheon JH, Park SY, Kim HH, Kim KB. Effects of Hataedock with Douchi on 2,4-dinitrofluorobenzene-induced Atopic Dermatitis-like Skin Lesion in NC/Nga Mice. J Physiol & Pathol Korean Med. 2016;30(2):109-15. https://doi.org/10.15188/kjopp.2016.04.30.2.109
  19. Miller AK, Benson JM, Muanza DN, Smith JR, Shepherd DM. Anti-inflammatory effects of natural product formulations on murine dendritic cells. J Diet 2011;8(3):19-33. https://doi.org/10.3109/19390211.2010.542233
  20. Yeh CY, Jung CJ, Huang CN, Huang YC, Lien HT, Wang WB et al. A legume product fermented by Saccharomyces cerevisiae modulates cutaneous atopic dermatitis-like inflammation in mice. BMC Complement Altern Med. 2014;14:194-201. https://doi.org/10.1186/1472-6882-14-194
  21. Kim HY, Ahn SH, Yang IJ, Kim KB. Effect of Skin Lipid Barrier Formation of Hataedock Treatment with Douchi. J Korean Med. 2017;38(2):41-52. https://doi.org/10.13048/jkm.17016
  22. Kulling SE, Honig DM, Simat TJ, Metzler M. Oxidative in vitro metabolism of the soy phytoestrogens daidzein and genistein. J agrfood chem. 2000;48(10):4963-72. https://doi.org/10.1021/jf000524i
  23. Rimbach G, De Pascual-Teresa S, Ewins BA, Matsugo S, Uchida Y, Minihane AM et al. Antioxidant and free radical scavenging activity of isoflavone metabolites. Xenobiotica. 2003;33(9):913-25. https://doi.org/10.1080/0049825031000150444
  24. Kusunoki T, Higashi H, Hosoi S, Hata D, Sugie K, Mayumi M et al. Tyrosine phosphorylation and its possible role in superoxide production by human neutrophils stimulated with FMLP and IgG. Biochem Biophys Res Commun. 1992;183(2):789-96. https://doi.org/10.1016/0006-291X(92)90552-V
  25. Record IR, Dreosti IE, McInerney JK. The antioxidant activity of genistein in vitro. J Nutr Biochem. 1995;6(9):481-5. https://doi.org/10.1016/0955-2863(95)00076-C
  26. Wei H, Cai Q, Rahn RO. Inhibition of UV light- and Fenton reaction-induced oxidative DNA damage by the soybean isoflavone genistein. Carcinogenesis. 1996;17(1):73-77. https://doi.org/10.1093/carcin/17.1.73