Journal of Yeungnam Medical Science

Yeungnam University College of Medicine, Yeungnam University Institute Medical Science (영남대 의대 학술지 편집위원회)
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Double primary lung adenocarcinoma diagnosed by epidermal growth factor receptor mutation status

  • Kwon, Oh Jung (Department of Internal Medicine, Konyang University Hospital) ;
  • Lee, Min Hyeok (Department of Internal Medicine, Konyang University Hospital) ;
  • Kang, Sung Ju (Department of Internal Medicine, Konyang University Hospital) ;
  • Kim, Seul Gi (Department of Internal Medicine, Konyang University Hospital) ;
  • Jeong, In Beom (Department of Internal Medicine, Konyang University Hospital) ;
  • Jeong, Ji Yun (Department of Pathology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine) ;
  • Cha, Eun Jung (Department of Pathology, Konyang University Hospital) ;
  • Cho, Do Yeun (Department of Internal Medicine, Konyang University Hospital) ;
  • Kim, Young Jin (Department of Thoracic Surgery, Konyang University Hospital) ;
  • Son, Ji Woong (Department of Internal Medicine, Konyang University Hospital)
  • Received : 2016.07.11
  • Accepted : 2016.09.26
  • Published : 2017.12.31
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Abstract

A nodular density was detected on a chest radiograph taken from a 57-year-old Korean woman who was visiting a hospital for a routine check. Chest computed tomography revealed a 4.8 cm lobulated mass in the right lung and another focal nodular lesion in the left lung; biopsies of both lungs revealed adenocarcinoma. We conducted DNA sequencing and peptide nucleic acid clamping to investigate the potential double primary lung cancer. The results verified that the mass in the right lung had a mutation in the epidermal growth factor receptor, whereas the nodule in the left lung had a wild-type sequence, showing that these two were genetically different cancers from one another. Thus, we demonstrate that genetic testing is useful in determining double primary lung cancer, and we herein report on this case.

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References

  1. Xue X, Liu Y, Pan L, Wang Y, Wang K, Zhang M, et al. Diagnosis of multiple primary lung cancer: a systematic review. J Int Med Res 2013;41:1779-87. https://doi.org/10.1177/0300060513504707
  2. Beyreuther H. Multiplicitat von Carcinomen bei einem Fall von sog. "Schneeberger" Lungenkrebs mit Tuberkulose. Virchows Arch Path Anat 1924;250:230-43. https://doi.org/10.1007/BF01891568
  3. Rea F, Zuin A, Callegaro D, Bortolotti L, Guanella G, Sartori F. Surgical results for multiple primary lung cancers. Eur J Cardiothorac Surg 2001;20:489-95. https://doi.org/10.1016/S1010-7940(01)00858-2
  4. Lee HJ, Xu X, Kim H, Jin Y, Sun P, Kim JE, et al. Comparison of direct sequencing, PNA clamping-real time polymerase chain reaction, and pyrosequencing methods for the detection of EGFR mutations in non-small cell lung carcinoma and the correlation with clinical responses to EGFR tyrosine kinase inhibitor treatment. Korean J Pathol 2013;47:52-60. https://doi.org/10.4132/KoreanJPathol.2013.47.1.52
  5. Martini N, Melamed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg 1975;70:606-12.
  6. Chang YL, Wu CT, Lee YC. Surgical treatment of synchronous multiple primary lung cancers: experience of 92 patients. J Thorac Cardiovasc Surg 2007;134:630-7. https://doi.org/10.1016/j.jtcvs.2007.06.001
  7. Ostrovnaya I, Olshen AB, Seshan VE, Orlow I, Albertson DG, Begg CB. A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data. Stat Med 2010;29:1608-21.
  8. Girard N, Ostrovnaya I, Lau C, Park B, Ladanyi M, Finley D, et al. Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers. Clin Cancer Res 2009;15:5184-90. https://doi.org/10.1158/1078-0432.CCR-09-0594
  9. Chuang JC, Shrager JB, Wakelee HA, Neal JW. Concordant and discordant EGFR mutations in patients with multifocal adenocarcinomas: implications for EGFR-targeted therapy. Clin Ther 2016;38:1567-76. https://doi.org/10.1016/j.clinthera.2016.06.005
  10. Girard N, Deshpande C, Azzoli CG, Rusch VW, Travis WD, Ladanyi M, et al. Use of epidermal growth factor receptor/ Kirsten rat sarcoma 2 viral oncogene homolog mutation testing to define clonal relationships among multiple lung adenocarcinomas:comparison with clinical guidelines. Chest 2010;137:46-52. https://doi.org/10.1378/chest.09-0325