공업화학 (Applied Chemistry for Engineering)

  • 제28권2호
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  • Pages.141-152
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  • 2017
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  • 1225-0112(pISSN)
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  • 2288-4505(eISSN)
한국공업화학회 (The Korean Society of Industrial and Engineering Chemistry)
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Inverse Electron-demand Diels-Alder 반응을 이용한 핵의학 영상 프로브의 합성 및 활용

Synthesis of PET and SPECT Radiotracers Using Inverse Electron-demand Diels-Alder Reaction

  • ;
  • 전종호 (한국원자력연구원 첨단방사선연구소)
  • Mushtaq, Sajid (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Jeon, Jongho (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • 투고 : 2017.03.07
  • 심사 : 2017.03.21
  • 발행 : 2017.04.10
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⟨ 이전 논문 다음 논문 ⟩

초록

1,2,4,5-테트라진 유도체를 이용한 inverse electron-demand Diels-Alder (IEDDA) 반응은 다양한 생체물질, 고분자, 나노 물질 복합체의 효율적인 합성에 폭넓게 활용되고 있다. IEDDA는 유기용매에서뿐만 아니라 생리학적 조건 하에서도 매우 특이적이며 빠른 반응속도를 가지고 있는 것으로 알려져 있다. 이러한 특성으로 인해 본 반응은 다양한 생물학적 활성을 가지는 물질의 방사성동위원소 표지와 분자영상 및 질병 치료를 위한 방사성의약품 개발에도 활발히 응용되고 있다. 본 리뷰 논문은 IEDDA 반응을 방사화학 및 핵의학 분야에서 이용한 최근 연구 동향 및 연구 결과 그리고 향후 전망에 대해 소개하고자 한다.

Inverse electron-demand Diels-Alder reactions (IEDDA) between tetrazine derivatives and strained dienophiles have attracted a lot of attention for the efficient conjugation of biomolecules, polymers, and nanomaterials. Excellent specificity, exceptionally fast reaction rate, and biocompatibility are key features of IEDDA. Therefore, it has also been applied to the development of new labeling methods using several radioisotopes and development of radiotracers to carry out various nuclear imaging as well as therapeutic studies. The purpose of this review is to introduce the reader to the recent advances and applications of IEDDA in the fields of radiochemistry and nuclear medicine.

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참고문헌

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  2. Recent Advances in Bioorthogonal Click Chemistry for Efficient Synthesis of Radiotracers and Radiopharmaceuticals vol.24, pp.19, 2017, https://doi.org/10.3390/molecules24193567