DOI QR코드

DOI QR Code

Risk Factors of Proximal Junctional Kyphosis after Multilevel Fusion Surgery : More Than 2 Years Follow-Up Data

  • Kim, Do Keun (Department of Neurosurgery, Inha University Hospital, Inha University School of Medicine) ;
  • Kim, Ji Yong (Department of Neurosurgery, Na Eun Hospital) ;
  • Kim, Do Yeon (Ba Reun Na Mu Neurosurgical Clinic) ;
  • Rhim, Seung Chul (Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Yoon, Seung Hwan (Department of Neurosurgery, Inha University Hospital, Inha University School of Medicine)
  • Received : 2016.07.27
  • Accepted : 2016.10.28
  • Published : 2017.03.01

Abstract

Objective : Proximal junctional kyphosis (PJK) is radiologic finding, and is defined as kyphosis of >$10^{\circ}$ at the proximal end of a construct. The aim of this study is to identify factors associated with PJK after segmental spinal instrumented fusion in adults with spinal deformity with a minimum follow-up of 2 years. Methods : A total of 49 cases of adult spinal deformity treated by segmental spinal instrumented fusion at two university hospitals from 2004 to 2011 were enrolled in this study. All enrolled cases included at least 4 or more levels from L5 or the sacral level. The patients were divided into two groups based on the presence of PJK during follow-up, and these two groups were compared to identify factors related to PJK. Results : PJK was observed in 16 of the 49 cases. Age, sex and mean follow-up duration were not statistically different between two groups. However, mean bone marrow density (BMD) and mean back muscle volume at the T10 to L2 level was significantly lower in the PJK group. Preoperatively, the distance between the C7 plumb line and uppermost instrumented vertebra (UIV) were no different in the two groups, but at final follow-up a significant intergroup difference was observed. Interestingly, spinal instrumentation factors, such as, receipt of a revision operation, the use of a cross-link, and screw fracture were no different in the two groups at final follow-up. Conclusion : Preoperative BMD, sagittal imbalance at UIV, and thoracolumbar muscle volume were found to be strongly associated with the presence of PJK.

Keywords

References

  1. Beneke R, Neuerburg J, Bohndorf K : Muscle cross-section measurement by magnetic resonance imaging. Eur J Appl Physiol Occup Physiol 63 : 424-429, 1991 https://doi.org/10.1007/BF00868073
  2. Terracciano C, Celi M, Lecce D, Baldi J, Rastelli E, Lena E, et al. : Differential features of muscle fiber atrophy in osteoporosis and osteoarthritis. Osteoporos Int 24 : 1095-1100, 2013 https://doi.org/10.1007/s00198-012-1990-1
  3. Cho SK, Shin JI, Kim YJ : Proximal junctional kyphosis following adult spinal deformity surgery. Eur Spine J 23 : 2726-2736, 2014 https://doi.org/10.1007/s00586-014-3531-4
  4. Cholewicki J, Panjabi MM, Khachatryan A : Stabilizing function of trunk flexor-extensor muscles around a neutral spine posture. Spine (Phila Pa 1976) 22 : 2207-2212, 1997 https://doi.org/10.1097/00007632-199710010-00003
  5. Glattes RC, Bridwell KH, Lenke LG, Kim YJ, Rinella A, Edwards C 2nd : Proximal junctional kyphosis in adult spinal deformity following long instrumented posterior spinal fusion : incidence, outcomes, and risk factor analysis. Spine (Phila Pa 1976) 30 : 1643-1649, 2005 https://doi.org/10.1097/01.brs.0000169451.76359.49
  6. Hyun SJ, Rhim SC : Clinical outcomes and complications after pedicle subtraction osteotomy for fixed sagittal imbalance patients : a long-term follow-up data. J Korean Neurosurg Soc 47 : 95-101, 2010 https://doi.org/10.3340/jkns.2010.47.2.95
  7. Harrison DE, Colloca CJ, Harrison DD, Janik TJ, Haas JW, Keller TS : Anterior thoracic posture increases thoracolumbar disc loading. Eur Spine J 14 : 234-242, 2005 https://doi.org/10.1007/s00586-004-0734-0
  8. Kang CH, Shin MJ, Kim SM, Lee SH, Lee CS : MRI of paraspinal muscles in lumbar degenerative kyphosis patients and control patients with chronic low back pain. Clin Radiol 62 : 479-486, 2007 https://doi.org/10.1016/j.crad.2006.12.002
  9. Kim HJ, Bridwell KH, Lenke LG, Park MS, Ahmad A, Song KS, et al. : Proximal junctional kyphosis results in inferior SRS pain subscores in adult deformity patients. Spine (Phila Pa 1976) 38 : 896-901, 2013 https://doi.org/10.1097/BRS.0b013e3182815b42
  10. Kim YJ, Bridwell KH, Lenke LG, Glattes CR, Rhim S, Cheh G : Proximal junctional kyphosis in adult spinal deformity after segmental posterior spinal instrumentation and fusion : minimum five-year follow-up. Spine (Phila Pa 1976) 33 : 2179-2184, 2008 https://doi.org/10.1097/BRS.0b013e31817c0428
  11. Le Huec JC, Saddiki R, Franke J, Rigal J, Aunoble S : Equilibrium of the human body and the gravity line : the basics. Eur Spine J 20 Suppl 5 : 558-563, 2011 https://doi.org/10.1007/s00586-011-1939-7
  12. Lee GA, Betz RR, Clements DH 3rd, Huss GK : Proximal kyphosis after posterior spinal fusion in patients with idiopathic scoliosis. Spine (Phila Pa 1976) 24 : 795-799, 1999 https://doi.org/10.1097/00007632-199904150-00011
  13. Legaye J, Duval-Beaupere G, Hecquet J, Marty C : Pelvic incidence : a fundamental pelvic parameter for three-dimensional regulation of spinal sagittal curves. Eur Spine J 7 : 99-103, 1998 https://doi.org/10.1007/s005860050038
  14. Lonner BS, Newton P, Betz R, Scharf C, O'Brien M, Sponseller P, et al. : Operative management of Scheuermann's kyphosis in 78 patients : radiographic outcomes, complications, and technique. Spine (Phila Pa 1976) 32 : 2644-2652, 2007 https://doi.org/10.1097/BRS.0b013e31815a5238
  15. Maruo K, Ha Y, Inoue S, Samuel S, Okada E, Hu SS, et al. : Predictive factors for proximal junctional kyphosis in long fusions to the sacrum in adult spinal deformity. Spine (Phila Pa 1976) 38 : E1469-E1476, 2013 https://doi.org/10.1097/BRS.0b013e3182a51d43
  16. Roussouly P, Gollogly S, Noseda O, Berthonnaud E, Dimnet J : The vertical projection of the sum of the ground reactive forces of a standing patient is not the same as the C7 plumb line : a radiographic study of the sagittal alignment of 153 asymptomatic volunteers. Spine (Phila Pa 1976) 31 : E320-E325, 2006 https://doi.org/10.1097/01.brs.0000218263.58642.ff
  17. Roussouly P, Pinheiro-Franco JL : Sagittal parameters of the spine : biomechanical approach. Eur Spine J 20 Suppl 5 : 578-585, 2011
  18. Takemitsu Y, Harada Y, Iwahara T, Miyamoto M, Miyatake Y : Lumbar degenerative kyphosis. Clinical, radiological and epidemiological studies. Spine (Phila Pa 1976) 13 : 1317-1326, 1988 https://doi.org/10.1097/00007632-198811000-00019
  19. Yagi M, King AB, Boachie-Adjei O : Incidence, risk factors, and natural course of proximal junctional kyphosis : surgical outcomes review of adult idiopathic scoliosis. Minimum 5 years of follow-up. Spine (Phila Pa 1976) 37 : 1479-1489, 2012 https://doi.org/10.1097/BRS.0b013e31824e4888

Cited by

  1. Fine-tuning the Predictive Model for Proximal Junctional Failure in Surgically Treated Patients With Adult Spinal Deformity vol.43, pp.11, 2018, https://doi.org/10.1097/brs.0000000000002415
  2. Proximal junctional kyphosis in adult spinal deformity: a novel predictive index vol.27, pp.9, 2018, https://doi.org/10.1007/s00586-018-5514-3
  3. Paraspinal muscle size as an independent risk factor for proximal junctional kyphosis in patients undergoing thoracolumbar fusion : Presented at the 2019 AANS/CNS Joint Section on Disorders of the Spi vol.31, pp.3, 2019, https://doi.org/10.3171/2019.3.spine19108
  4. Paraspinal muscle size as an independent risk factor for proximal junctional kyphosis in patients undergoing thoracolumbar fusion : Presented at the 2019 AANS/CNS Joint Section on Disorders of the Spi vol.31, pp.3, 2019, https://doi.org/10.3171/2019.3.spine19108
  5. Should Thoracolumbar Junction Be Always Avoided as Upper Instrumented Vertebra in Long Instrumented Fusion for Adult Spinal Deformity? : Risk Factor Analysis for Proximal Junctional Failure vol.45, pp.10, 2017, https://doi.org/10.1097/brs.0000000000003364
  6. Osteoporosis and Spine Surgery : A Critical Analysis Review vol.8, pp.6, 2017, https://doi.org/10.2106/jbjs.rvw.19.00160
  7. Current concepts in level selection for fusion in the adolescent idiopathic scoliosis patient vol.3, pp.2, 2017, https://doi.org/10.4103/isj.isj_67_19
  8. A Systematic Review of Treatment Strategies for the Prevention of Junctional Complications After Long-Segment Fusions in the Osteoporotic Spine vol.11, pp.5, 2017, https://doi.org/10.1177/2192568220939902
  9. The prevalence of proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) in patients undergoing circumferential minimally invasive surgical (cMIS) correction for adult spinal deformi vol.9, pp.5, 2021, https://doi.org/10.1007/s43390-021-00319-1
  10. Sarcopenia Is an Independent Risk Factor for Proximal Junctional Disease Following Adult Spinal Deformity Surgery vol.12, pp.1, 2017, https://doi.org/10.1177/2192568220947050