Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Hypothermia Regulates Insulin-like Growth Factor 1 Gene Expression in PC12 Cells

  • Yoo, Bo-Kyung (Department of Anatomy & Cell Biology, College of Medicine, Chungnam National University) ;
  • Kwon, Kisang (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University) ;
  • Lee, Eun Ryeong (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University) ;
  • Kim, Seung-Whan (Department of Emergency Medicine, Chungnam National University Hospital) ;
  • Yu, Kweon (Korea Research Institute of Bioscience & Biotechnology) ;
  • Kwon, O-Yu (Department of Anatomy & Cell Biology, College of Medicine, Chungnam National University)
  • Received : 2016.10.14
  • Accepted : 2017.02.09
  • Published : 2017.03.31
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Abstract

In this study, we evaluated the effects of various hypothermic conditions ($32^{\circ}C$), including lithium chloride treatment, on insulin-like growth factor 1 (IGF-1) gene expression in PC12 cells. The results show that short-term hypothermic treatment (<1 day) resulted in relatively higher IGF-1 gene expression than did longer-term treatment (>1 day). Repeated switching between normal temperature and hypothermia every 2 h increased IGF-1 gene expression approximately 3-4-fold. These findings indicate that hypothermia dynamically regulates IGF-1 gene expression. This study could be helpful for the development of treatment and diagnostic strategies for ischemia.

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References

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