생명과학회지 (Journal of Life Science)

  • 제27권3호
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  • Pages.275-282
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  • 2017
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  • 1225-9918(pISSN)
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  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
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부산지역 호흡기감염증 환자로부터 분리한 아데노바이러스와 보카바이러스의 유행양상 분석

Epidemiological Characterization of Adenovirus and Human Bocavirus Detected Acute Respiratory Patients in Busan

  • 황수정 (부산광역시 보건환경연구원) ;
  • 김남호 (부산광역시 보건환경연구원) ;
  • 박동주 (부산광역시 보건환경연구원) ;
  • 구평태 (부산광역시 보건환경연구원) ;
  • 이미옥 (부산광역시 보건환경연구원) ;
  • 진성현 (부산광역시 보건환경연구원)
  • Hwang, Su-Jeong (Busan Metropolitan City Institute of Health & Environment) ;
  • Kim, Nam-Ho (Busan Metropolitan City Institute of Health & Environment) ;
  • Park, Dong-Ju (Busan Metropolitan City Institute of Health & Environment) ;
  • Ku, Pyung-Tae (Busan Metropolitan City Institute of Health & Environment) ;
  • Lee, Mi-Ok (Busan Metropolitan City Institute of Health & Environment) ;
  • Jin, Sung-Hyun (Busan Metropolitan City Institute of Health & Environment)
  • 투고 : 2016.10.06
  • 심사 : 2016.11.11
  • 발행 : 2017.03.30
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초록

부산지역 급성호흡기감염증으로 내원한 환자에서 호흡기바이러스 검사를 시행하여 아데노바이러스 및 보카바이러스의 특징적인 임상증상 및 유행양상을 알아보고자 하였다. 3,230명의 환자에서 총 1,485건(46.0%)의 호흡기바이러스가 검출되었고 이 중 아데노바이러스 257건(8.0%), 보카바이러스 68건(2.1%)을 확인하였다. 성별 발생양상은 남자가 여자보다 아데노바이러스, 보카바이러스로 인한 호흡기감염증에 취약하였으며, 모두 1~5세 연령군에서 높은 검출률을 보여 영 유아의 주요 감염요인임을 확인할 수 있었다. 주요 임상증상으로 아데노바이러스는 발열, 두통이 보카바이러스는 천명음이 통계적으로 유의하였다. 아형분석결과, 아데노바이러스는 1~6, 8형의 혈청형을 확인하였고 기존 분리주와 97% 이상의 상동성을 보였다. 연도별 유행 혈청형은 2011년 아데노바이러스 1형, 2012년 3형과 4형, 2013년에는 3형이 우점적으로 유행하였다. 아데노바이러스 3형의 경우, 대유행을 유발하는 아형으로 보인다. 보카바이러스는 모두 1형으로 나타났다.

Adenovirus (ADV) and human bocavirus (hBoV) cause acute respiratory tract infections, and are often associated with increased rates of hospitalization and death, particularly in infants and young children. The aim of this study was to analyze the clinical features and molecular phylogeny of ADV and hBoV isolated in Busan, from January 2011 to November 2013. In total, 3,230 specimens (throat swabs) were collected from patients with influenza-like illnesses and acute respiratory tract infections. Multiplex real-time RT-PCR was performed to detect eight respiratory viru [rhinovirus, adenovirus, respiratory syncytial virus, human coronavirus, human metapneumovirus, human bocavirus, parainfluenza virus and influenza virus] and detected 1,485(46.0%) cases. Among 1,485 positive specimens, 257(8.0%) cases were ADV and 68(2.1%) cases of hBoV. A significant clinical feature of ADV is fever and headache whereas hBoV is wheezing. Serotypic distributions of isolated ADV and hBoV were analyzed by sequencing of hexon and VP1/VP2 gene, respectively. ADV was identified seven different serotypes(1~6, 8), revealing a high similarity among the isolates (>97%). The predominant types of ADV were type 1 in 2011, type 3 and 4 in 2012, type 3 in 2013, respectively. ADV type 3 was major causative type during outbreaks in 2013. All of the hBoV was identified as hBoV type 1.

키워드

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피인용 문헌

  1. Distribution and Characterization of Airborne Respiratory Pathogens in Public Facilities vol.48, pp.4, 2018, https://doi.org/10.4167/jbv.2018.48.4.121