Journal of Dental Rehabilitation and Applied Science (구강회복응용과학지)

Korean Academy of Stomatognathic Function and Occlusion (대한턱관절교합학회)
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Effects of host modulation by nonsteroidal anti-inflammatory drugs on periodontal disease: a systematic review and meta-analysis

비스테로이드성 항염증제를 이용한 숙주조절이 치주질환에 미치는 영향: 체계적 고찰 및 메타 분석

  • Kang, Dae-Young (Department of Periodontology, College of Dentistry, Dankook University) ;
  • Cho, In-Woo (Department of Periodontology, College of Dentistry, Dankook University) ;
  • Shin, Hyun-Seung (Department of Periodontology, College of Dentistry, Dankook University) ;
  • Ahn, Hyeong-Sik (Institute for Evidence-based Medicine, Department of Preventive Medicine, College of Medicine, Korea University) ;
  • Kim, Hyun-Jung (Institute for Evidence-based Medicine, Department of Preventive Medicine, College of Medicine, Korea University) ;
  • Park, Jung-Chul (Department of Periodontology, College of Dentistry, Dankook University)
  • 강대영 (단국대학교 치과대학 치주과학교실) ;
  • 조인우 (단국대학교 치과대학 치주과학교실) ;
  • 신현승 (단국대학교 치과대학 치주과학교실) ;
  • 안형식 (근거중심 의학연구소, 고려대학교 의과대학 예방의학교실) ;
  • 김현정 (근거중심 의학연구소, 고려대학교 의과대학 예방의학교실) ;
  • 박정철 (단국대학교 치과대학 치주과학교실)
  • Received : 2017.01.06
  • Accepted : 2017.03.09
  • Published : 2017.03.31
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Abstract

Purpose: Nonsteroidal anti-inflammatory drugs that prohibit biosynthesis of arachidonic acid metabolites have been considered potent host modulation agents. The aim of this review was to determine the effect of nonsteroidal anti-inflammatory drugs adjunctive with nonsurgical periodontal treatment in patients with periodontal disease. Materials and Methods: Three electronic databases were searched to identify relevant studies. The methodological quality and mean differences of the change in clinical attachment level and probing depth were analyzed according to Cochrane review methods. Results: Twelve studies were included in the methodological assessment and nine studies were suitable for inclusion in the meta-analysis. The mean difference in the clinical attachment level gain did not differ significantly between the nonsteroidal anti-inflammatory drugs and control groups at any observation time. The highest mean difference in clinical attachment level gain was 0.30 mm at 4 weeks (95% confidence interval = -0.37 to 0.97). There was a significant mean difference in the probing depth reduction, of 0.34 mm (95% confidence interval = 0.29 to 0.40) at 6 weeks. Conclusion: Therefore, nonsteroidal anti-inflammatory drugs have additional therapeutic effect when administrated with nonsurgical periodontal treatment.

목적: 아라키돈산 대사물의 생합성을 억제하는 비스테로이드성 항염증제는 잠재적인 숙주조절제로 고려되고 있다. 이종설의 목적은 비스테로이드성 항염증제를 비외과적 치주치료와 병용하였을 때 치주질환자에 미치는 영향을 평가하는 데 있다. 연구 재료 및 방법: 관련된 연구를 확인하기 위하여 세 전자 데이터베이스를 검색하였다. Cochrane의 고찰 방법론에 따라 방법론적인 질, 임상 부착 수준과 탐침 깊이 변화량에 대한 평균 차이를 분석하였다. 결과: 총 12개의 연구의 방법론을 평가하였고 이중 9개의 연구에 대해 메타-분석을 시행하였다. 임상 부착 수준의 변화에 대한 평균차의 경우 모든 관찰기간에서 비스테로이드성 항염증제 군과 대조군간 유의차를 보이지 않았다. 가장 큰 평균차는 4주 때 0.30 mm로 나타났다(95% 신뢰구간 = -0.37 to 0.97). 탐침 깊이 변화에 대한 평균차는 6주 때 0.34 mm(95% 신뢰구간 = 0.29 to 0.40)로 유의차를 보였다. 결론: 이를 토대로 하였을 때 비스테로이드성 항염증제를 비외과적 치주치료와 병용하여 투여하였을 때 부가적으로 치료효과를 증대시킬 수 있을 것으로 생각된다.

Keywords

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