Mass Spectrometry Letters

Korean Society for Mass Spectrometry (한국질량분석학회)
권호 표지
DOI QR코드

DOI QR Code

Comparative Study of Extracting Fragrance Allergens by GC-MS/MS

  • Lee, In Ja (Seoul Water Institute, Seoul Metropolitan Government) ;
  • Ahn, Jae-Chan (Seoul Water Institute, Seoul Metropolitan Government) ;
  • Kim, Bogsoon (Seoul Water Institute, Seoul Metropolitan Government) ;
  • Chung, Deukmo (Seoul Water Institute, Seoul Metropolitan Government)
  • Received : 2017.03.06
  • Accepted : 2017.03.20
  • Published : 2017.03.30
Download PDF
⟨ Previous Next ⟩

Abstract

Products containing any one or more of 26 fragrance allergens likely to cause contact allergies, are required under the 2008 domestic cosmetic law to be labeled when their concentrations exceed a certain range. This study focuses on the comparison and development of analytical methods based on headspace-solid phase micro extraction (HS-SPME) and liquid-liquid extraction (LLE) methods followed by GC-MS/MS for 24 of the fragrance allergens excepting for two natural materials in water samples. Using the developed HS-SPME method, 15 of the 24 fragrance allergens were analyzed and 9 compounds which have relatively low $logK_{OW}$ values (below about 2.5) were not extracted, and the correlation coefficient ($r^2$) of the calibration curve for quantification showed linearity of 0.9969 or more, and the method detection limits (MDL) and the limits of quantification (LOQ) were $0.078{\sim}0.582{\mu}g/L$ and $0.261{\sim}1.940{\mu}g/L$, respectively. In the case of using the optimized LLE method, all 24 fragrance allergens were analyzed, and the correlation coefficient ($r^2$) of the calibration curve for quantification showed linearity of 0.9957 or more, MDL and LOQ were $0.020{\sim}0.138{\mu}g/L$ and $0.065{\sim}0.440{\mu}g/L$, respectively.

Keywords

References

  1. Scientific Committee on Consumer Safety (SCCS). Opinion on Fragrance Allergens in Cosmetic Products; 15th Plenary Meeting, Brussels (Belgium), June 26-27, 2012, p 10.
  2. Godayol, A.; Besalu, E.; Antico, E.; Sanchez, J. M. Chemosphere 2015, 119, 363. https://doi.org/10.1016/j.chemosphere.2014.06.072
  3. Becerril, E.; Lamas, P.; Sanchez-Prado, L.; Llompart, M.; Lores, M.; Garcia-Jares, G. Talanta 2010, 83, 464. https://doi.org/10.1016/j.talanta.2010.09.038
  4. Celeiro, M.; Guerra, E.; Lamas, J. P.; Lores, M.; Garcia-Jares, G.; Llompart, M. J. Chromatogr. A 2014, 1344, 1. https://doi.org/10.1016/j.chroma.2014.03.070
  5. Godayol, A.; Gonzalez-Olmos, R.; Sanchez, J. M.; Antico, E. Chemosphere 2015, 125, 25. https://doi.org/10.1016/j.chemosphere.2015.01.009
  6. Becerril-Bravo, E.; Lamas, J. P.; Sanchez-Prado, L.; Lores, M; Garcia-Jares, G.; Jimenez, B.; Llompart, M. Chemosphere 2010, 81, 1378. https://doi.org/10.1016/j.chemosphere.2010.09.028
  7. Seo, C. D.; Son, H. J.; Lee, I. S.; Oh, J. E. J. Korean Soc. Environ. Eng. 2010, 32, 615.
  8. Lee, I.; Lee, C.; Heo, S.; Lee, J. J. Korean Soc. Environ. Eng. 2011, 33, 821. https://doi.org/10.4491/KSEE.2011.33.11.821
  9. Seo, C. D.; Son, H. J.; Yoom, H. S.; Choi, D. H.; Ryu, D. C. J. Korean Soc. Environ. Eng. 2012, 34, 195. https://doi.org/10.4491/KSEE.2012.34.3.195
  10. Seo, C. D.; Son, H. J.; Yoom, H. S.; Choi, J. T.; Ryu, D. C.; Kwon, K. W.; Jang, S. H. J. Korean Soc. Environ. Eng. 2014, 36, 387. https://doi.org/10.4491/KSEE.2014.36.6.387
  11. Martinez, C.; Ramirez, N.; Gomez, V.; Pocurull, E.; Borrull, F. Talanta 2013, 116, 937. https://doi.org/10.1016/j.talanta.2013.07.055
  12. Divisova, R.;Vitova, E.; Divis, P.; Zemanova, J.; Omelkova J. Acta Chromatogr. 2015, 27, 509. https://doi.org/10.1556/AChrom.27.2015.3.8
  13. Lamas, J. P., Sanchez-Prado, L.; Garcia-Jares, C.; Llompart, M. Anal. Bioanal. Chem. 2009, 394, 1399. https://doi.org/10.1007/s00216-009-2829-2
  14. Niederer, M.; Bollhalder, R.; Hohl, C. J. Chromatogr. A 2006, 1132, 109. https://doi.org/10.1016/j.chroma.2006.07.055
  15. Villa, C.; Gambaro, R.; Mariani, E.; Dorato, S. J. Pharma. Biomedi. Anal. 2007, 44, 755. https://doi.org/10.1016/j.jpba.2007.03.020
  16. Rey, A.; Corbi, E.; Peres, C.; David, N. J. Chromatogr. A 2015, 1404, 95. https://doi.org/10.1016/j.chroma.2015.05.045
  17. Desmedt, B.; Canfyn, M.; Pype, M.; Baudewyns, S.; Hanot, V.; Courselle, P.; DeBeer, J. O.; Rogiers, V.; DePaepe, K.; Deconinck, E. Talanta 2015, 131, 444. https://doi.org/10.1016/j.talanta.2014.08.006
  18. Vallecillos, L.; Pocurull, E.; Borrull, F. Talanta 2012, 99, 824. https://doi.org/10.1016/j.talanta.2012.07.036

Cited by

  1. Determining Collision Cross-Sections of Aromatic Compounds in Crude Oil by Using Aromatic Compound Mixture as Calibration Standard vol.40, pp.2, 2018, https://doi.org/10.1002/bkcs.11653