DOI QR코드

DOI QR Code

The Effect of Laser Acupuncture of Five-Transport-Points of the Heart Meridian in L-NAME-Induced Hypertensive Rats

수소음심경 오수혈 혈위별 레이저 침자가 고혈압 흰쥐의 혈압에 미치는 영향

  • Shin, Wook (Deparment of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Lee, Yumi (Deparment of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Kim, Wangin (Deparment of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Choi, Donghee (Deparment of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Kim, Mirae (Deparment of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Youn, Daehwan (Deparment of Acupoint & Meridian, College of Korean Medicine, Dongshin University) ;
  • Na, Changsu (Deparment of Acupoint & Meridian, College of Korean Medicine, Dongshin University)
  • 신욱 (동신대학교 한의과대학 경락경혈학교실) ;
  • 이유미 (동신대학교 한의과대학 경락경혈학교실) ;
  • 김왕인 (동신대학교 한의과대학 경락경혈학교실) ;
  • 최동희 (동신대학교 한의과대학 경락경혈학교실) ;
  • 김미래 (동신대학교 한의과대학 경락경혈학교실) ;
  • 윤대환 (동신대학교 한의과대학 경락경혈학교실) ;
  • 나창수 (동신대학교 한의과대학 경락경혈학교실)
  • Received : 2017.03.15
  • Accepted : 2017.03.27
  • Published : 2017.03.27

Abstract

Objectives : The purpose of this study is to compare the effects of laser acupuncture to the 532 nm on the five transport points with the heart meridian for treatment to hypertensive disease in rats with L-NAME induced hypertensive. Methods : Hypertensive was induced by L-NAME for 3 weeks. The laser acupuncture therapy on the five transport points of heart meridian(Laser Well Point-HT9, Laser Brook Point-HT8. Laser Stream Point-HT7, Laser River Point-HT4 and Laser Sea Point-HT3) was treated twice a week for 5 times. The hypertensive was measured using a cardiac hypertrophy, atherogenic index, TG/HDL-cholesterol ratio, TCHO, HDLC, TG, AST, ALT, antioxidative effectiveness and glutathione peroxidase quality of hypertensive rats induced by L-NAME. Results : Blood pressure were decreased significantly after the laser acupuncture of Well, Brook and Sea Point groups. Cardiac hypertrophy were decreased at the laser acupuncture of Brook and Stream Point groups. Athrogenic index was decreased at the laser acupuncture of Well, Stream, River and Sea Point groups. TG/HDL-cholesterol ratio was decreased at the laser acupuncture of all groups. Total cholesterol was decreased significantly at the laser acupuncture of Well Point group. High density lipoprotein cholesterol and total cholesterol were decreased significantly at the laser acupuncture of Well, Stream and River Point groups. Triglyceride was decreased significantly at the laser acupuncture of Stream Point group. Cu/Zn-Superoxide Dismutase (Cu/Zn-SOD) and glutathione peroxidase(GPX) were increased significantly at the laser acupuncture of Well Point group. Conclusions : The laser acupuncture treatment in five transport points of the Heart Meridian was effective for lowering blood pressure, cardiac hypertrophy, Atherogenic index and HTR, and for enhancing antioxidant activity.

Keywords

References

  1. World Health Organization (WHO). (2013). A global brief on hypertension: Silent Killer, Global Public Health Crisis. 2013. World Health Organization, 2013 : WHO/DCO/WHD/
  2. Korea Health Statistics 2014. Korea National Health and Nutrition Examination Survey (KNHANES VI-2). Korean Ministry of Health and Welfare. 2014.
  3. Victor R. Arterial Hypertension. In : Goldman L, Ausiello D, editors, Cecil Textbook of Medicine, 22nd ed. Philadelphia : Saunders. 2004 : 346-637.
  4. James PA, Oparil S, Carter BL, Cushman WC, Dennison- Himmelfarb C, Hnadler J, et al. 2014 Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC8) The Journal of the American Medical Association. 2014 ; 311(5) : 507- 20. https://doi.org/10.1001/jama.2013.284427
  5. Neal B, MacMahon S, Chapman N. Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration. Lancet. 2000 ; 35(6) : 1955-64.
  6. Macklin EA, Wayne PM, Kalish LA, Valaskatgis P, Thompson J, Pian-Smith MC, et al. Stop Hypertension with the Acupuncture Research Program (SHARP): results of a randomized, controlled clinical trial. Hypertension. 2006 ; 48(5) : 838-45. https://doi.org/10.1161/01.HYP.0000241090.28070.4c
  7. Babichenko MA. Acupuncture reflexotherapy in the treatment of hypertension patients. Likrs'ka Sprava. 2000 ; (1) : 95-7.
  8. Yin CS, Seo BK, Park HJ, Cho MR, Jung WS, Choue RW, et al. Acupuncture, a promising adjunctive therapy for essential hypertension: a double-blind, randomized, controlled trial. Neurological Research. 2007 ; 29(1) : 98-103. https://doi.org/10.1179/016164107X172220
  9. Li P, Longhurst JC. Neural mechanism of electroacupuncture's hypotensive effects. Auton Neurosci. 2010 ; 157 : 24-30. https://doi.org/10.1016/j.autneu.2010.03.015
  10. Kim YS. The Effect of Acupuncture Treatment in Five Transport Points of the Heart Meridian on the Blood Pressure of Hypertensive Rats Induced by L-NAME. Department of Korean Medicine Graduate School of Dong-shin University. 2013
  11. Jin IH, Lyu CY, Jo ML. The effects of acupuncture Kyongo (L8), Puryu(K7), Kyongo(L8), Um-gok(K10) on Blood Pressure in Hypertensive RAT induced by 2K1C. The Journal of Korean Acupuncture & Moxibustion Society. 2003 ; 20(6) : 1-12.
  12. Kim JH, Kim KS. Effect of Acupuncture at the Sip Seon Loci on the Blood Pressure in Spontaneously Hypertensive Rats. Wonkwang University first issue. 1983 ; 183-203.
  13. Li P, Tjeng-A-Looi S, Longhurst JC. Rostral ventrolateral medullary opioid receptor subtypes in the inhibitory effect of electroacupuncture on reflex autonomic response in cats. Auton Neurosci. 2001 ; 89(1-2) : 38-47. https://doi.org/10.1016/S1566-0702(01)00247-8
  14. Syuu Y, Matsubara H, Kiyooka T, Hosogi S, Mohri S, Araki J, et al. Cardiovascular beneficial effects of electroacupuncture at Neiguan(PC-6) acupoint in anesthetized open-chest dog. Jpn J Physiol. 2001 ; 51(2) : 231-8. https://doi.org/10.2170/jjphysiol.51.231
  15. Williams T, Mueller K, Cornwall MW. Effect of acupuncture-point stimulation on diastolicblood pressure in hypertensive subjects. a preliminary study. Phys Ther. 1991 ; 71(7) : 523-9. https://doi.org/10.1093/ptj/71.7.523
  16. Yu YC, Han JW, Yuk TH, Lee HS. Effects of Aqua acupuncture of Semon Cuscutae on the Blood Pressure in Spontaneously Hypertensive Rats. The Journal of Korean Acupuncture & Moxibustion Society. 1998 ; 15(2) : 349-56.
  17. Kim SH, Jeong HK, Lee HS. Effects of Aqua Acupuncture of Radix SaIivae Miltriorrhizae Water Extract on Blood Pressure in Hypertensive Rats. The Journal of Korean Acupuncture & Moxibustion Society. 1999 ; 16(2) : 349-54.
  18. Lee HS, Yu YC, Kim ST, Kim KS. Effects of moxibustion on blood pressure and renal function in spontaneously hypertensive rats. Am J Chin Med. 1997 ; 25(1) : 21-6. https://doi.org/10.1142/S0192415X97000056
  19. Na CS, Youn DH, Choi CH, Lee SH, Oh KH, Jeong SH. The effects of traditional acupuncture techniques and green Laser acupuncture on the blood pressure in hypertensive rat induced by two kidney one clip. Korean Journal of Acupuncture. 2008 ; 25(2) : 199-210.
  20. Korean Acupuncture Society. Textbook Compilation Committee. Seoul : Jipmundang. 2012 ; 22(135) : 225-8.
  21. Vasil'ev AP, Strel'tsova NN. A possible mechanism of the hypotensive effect of laser irradiation in patients with ischemic heart disease with arterial hypertension. Vopr Kurortol Fizioter Lech Fiz Kult. 2001 ; (5) : 17-20.
  22. Sventek P, Turgeon A, Schiffrin EL. Vascular endothelin-1 gene expression and effect on blood pressure of chronic ETA endothelin receptor antagonism after nitric oxide synthase inhibition with L-NAME in normal rats. Circulation. 1997 ; 95 : 240-4. https://doi.org/10.1161/01.CIR.95.1.240
  23. The Korean Society of Hypertension. 2004 Korean hypertension treat-ment guidelines. Seoul : The Korean Society of Hypertension. 2004.
  24. Lewington S, Clarke R, Qizibash N, Peto R, Collins R, Prospective Studies Collaboration. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. 2002 ; 360 : 9349.
  25. Powers M. Jalowiec A. Profile of the well-Controlled. well-Adjusted Hypertensive Patients. Nurs Res. 1987 ; 36(2) : 106-10.
  26. Onder G, Pahor M, Gambassi G, Federici A, Savo A, Carbonin P, et al. Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly( GIFA). Cephalagia. 2003 ; 23(9) : 901-6. https://doi.org/10.1046/j.1468-2982.2003.00627.x
  27. Park JM., Shin AS, Park SU, Sohn IS, Jung WS, Moon SK. The acute effect of acupuncture on endothelial dysfunction in Patients with hypertension : A pilot, randomized, double-blind, placebo-controlled crossover trial. J of alternative and complementary medicine. 2010 ; 16(8) : 883-8. https://doi.org/10.1089/acm.2009.0427
  28. Zhao R, Fu LX, Xiong J, Li S, Wang ZL. The Effect of Acupuncture Therapy on Essential Hypertension: A Systematic Review of Long term Effect. Journal of Clinical Acupuncture and Moxibustion. 2011 ; 27(3) : 46-51.
  29. Zhou MM, Shi XM. Effect of Acupuncture Therapy for Essential Hypertension and the Influence of Acquired Factors on Antihypertensive Effect. Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease. 2012 ; 10(3) : 350-1.
  30. College of Oriental Medicine College of Rehabilitation Medicine. Dongui Rehabilitation Medicine Science. Seoul : Seowondang. 1995 ; 451-70.
  31. Kim YN. Oriental physiotherapy. Seoul : Hyunmunsa. 1999 : 266-321.
  32. Gwun BY. Physics of Lasers and Medical Utilization. Baptist Hospital Journal. 1991 ; 8 : 7-10.
  33. Bang SH, Youn DH, Na CS, Cho MR, Yim HJ. Effects of Invasive Low Level Laser Acupuncture Therapy(LLLAT) depending on capacity at LU7+LR5 on the Hyperlipemia Rats Induced by High Fat Diet. Korean Journal of Acupuncture. 2006 ; 23(1) : 1-14.
  34. Shuvalova IN, Klimenko IT, Svinina NG, Tsereteli MV, Zankina VG, Miasoed FR. The efficiency of low-intensity laser radiation in the treatment of arterial hypertension complicated by ischemic heart disease. Vopr Kurortol Fizioter Lech Fiz Kult. 2001 ; (4) : 3-6.
  35. Jin JP. Clinical application of Huangdineijing-Dogsongbon. Seoul : Bubin publisher. 2009 ; 499-523, 711.
  36. Youn CR, Kim YJ. Nangyeong Research house. Daejeon : Jumin publisher. 2002 ; 889-933.
  37. Lee C. Introduction to medicine. Chinese Medicine Department publisher. 2011 ; 89-99.
  38. Li, XL, Yu, GQ, Wang F, Xu YJ, Zhang QH, Zhao GJ et al. Department of CT and MRI. Chinese Journal of Medical Imaging Technology. 2014 ; 30(11) : 55-9.
  39. Seo BM, Sa B, Rye BG, Mo G, Lee YM, et al. Studies on the Resonance Characteristics of the Sagittal Sagittal Gut. Journal of Nanjing University of Traditional Chinese Medicine. 2007 ; 23(4) : 224-7
  40. Zhang ZY, Xu DS, Cui JJ, Zhang K, Jing XH, Bai WZ. Distribution of Substance P-positive nerve Fibers in Local Skin Tissues of Five Shu-Points of the Pericardium meridian in the Rat. Acupuncture Research. 2016 ; 41(4) : 298-302.
  41. Yi G, Xiuyun W, Tangping X, Zhihua D, Yunchen L. Effect of blood-letting puncture at twelve well-points of hand on consciounsness and heart rate in patients with apoplexy. J Tradit Chin Med. 2005 ; 25(2) : 85-9.
  42. Kim JS, Hwang W, Bae KT, Nam SS, Kim YS. Effect of Acupuncture for Mental Stress on Short-term Analysis of Heart Rate Variability(HRV). The Journal of Korean Acupuncture & Moxibustion Society. 2004 ; 21(5) : 227-39.
  43. Jung GK. Shin M. Effects of Electroacupuncture on Blood Pressure and Cardiac Function. Shanghai Acupuncture magazine. 1996 ; 15(5) : 11.
  44. Kae GJ, Ri PG. Young-do blood massage therapy. Chinese Acupuncture. 1984 ; 4(6) : 9.
  45. Park, SM, Yang CH, Park KH. Effect of Acupuncture at Um - Sohae (H3) Locus on Plasma Levels of Stress - related Hormones in Men. Journal of Korean acupuncture & moxibustion medicine society. 1990 ; 7(1) : 221-39.
  46. Tain YL, Huang LT, Lee CT, Chan JY, Hsu CN. Maternal citrulline supplementation prevents prenatal N(G)-nitro-L-arginine-methyl ester (L-NAME)-induced programmed hypertension in rats. Biol Reprod. 2015 ; 92(1): 1-7. https://doi.org/10.1095/biolreprod.114.125542
  47. Berkban T, Boonprom P, Bunbupha S, Welbat JU, Kukongviriyapan U, Kukongviriyapan V, et al. Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats. Nutrients. 2015 ; 7(7) : 5265-80. https://doi.org/10.3390/nu7075222
  48. Gonzalez J, Valls N, Brito R, Rodrigo R. Hypertension and oxidative stress: New insights. World J Cardiol. 2014 ; 6(6) : 353-66. https://doi.org/10.4330/wjc.v6.i6.353
  49. Shibata M1, Ichioka S, Kamiya A. Nitric oxide modulates oxygen consumption by arteriolar walls in rat skeletal muscle. Am J Physiol Heart Circ Physiol. 2005 ; 289(6) : H2673-9. https://doi.org/10.1152/ajpheart.00420.2005
  50. Maiorana A, O Driscoll G, Taylor R, Green D. Exercise and the nitric oxide vasodilator system. Sports Med. 2003 ; 33(14) : 1013-35. https://doi.org/10.2165/00007256-200333140-00001
  51. Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem Journal. 1994 ; 298 : 249-58. https://doi.org/10.1042/bj2980249
  52. Liu W, Zhu LQ, Chen SS, Lu SC, Tang J, Liu QG. Effect of twirling-reinforcing-reducing needling manipulations on contents of serum acetylcholine and arterial NOS and cGMP in stress-induced hypertension rats. Zhen Ci Yan Jiu. 2015 ; 40(2) : 136-40.
  53. Hwang HS, Kim YS, Ryu YH, Lee JE, Lee YS, Yang EJ, et al. Electroacupuncture Delays Hypertension Development through Enhancing NO/NOS Activity in Spontaneously Hypertensive Rats. Evid Based Complement Alternat Med. 2011 ; 2011 : 130529.
  54. Huo ZJ, Li Q, Tian GH, Zhou CM, Wei XH, Pan CS, et al. The ameliorating effects of long-term electroacupuncture on cardiovascular remodeling in spontaneously hypertensive rats. BMC Complement Altern Med. 2014 ; 14 : 118. https://doi.org/10.1186/1472-6882-14-118
  55. Im YK, Kim JP, Kim TH. University Meridian acyclovirism. Obi Planning. 2006 : 312-41, 351-73.
  56. Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, Olson EN. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell. 2002 ; 110(4) : 479-88. https://doi.org/10.1016/S0092-8674(02)00861-9
  57. Despres JP, Lemieux I. Dagenais GR, Cantin B, Lamarche B. HDL-C as a marker of coronary heart disease risk the Quebec cardiovascular study. Atherosclerosis. 2000 ; 153(2) : 263-72. https://doi.org/10.1016/S0021-9150(00)00603-1
  58. Kim YC, Kim YY, Chae YS, Shin HC, Park ES. A study of relationship between hypertension and hyperlipidemia in the health screening center. Korean Journal of Family Medicine. 1992 ; 13(5) : 410-19.
  59. Giumetti D, Liu K, Stamler R, Schoenberger JA, Shekelle RB, Stamler J. Need to prevent and control high-normal and high blood pressure, particularly so-called "mild" hypertension: epidemiological and clinical data. Prev Med. 1985 ; 14(4) : 396-412. https://doi.org/10.1016/0091-7435(85)90002-7
  60. Lee HR. Hyperlipidemia. Journal of Family Medicine. 1987 ; 8(7) : 14-5.
  61. Cho GW, Park JC, Kang JC. Comparative Study on the Risk Factors of Atherosclerosis in Cerebral Infarction and Myocardial Infarction. The Korean Journal of Internal Medicine. 1991 ; 41(4) : 469-77.
  62. Cho KK, Chung CH, Chung BK, Chae JK, Lee SI, Moon CO, et al. Original Articles : A Study on the Change of the Serum and Erythrocyte Lipoperoxides and Superoxide Dismutase Levels in Normal Persons and Hypertensive Patients. The Korean Journal of Internal Medicine. 1984 ; 27(9) : 1044-50.

Cited by

  1. 고혈압 침치료에 관한 최근 연구 동향 고찰 - Pubmed와 국내 논문 중심으로 - vol.41, pp.1, 2020, https://doi.org/10.22246/jikm.2020.41.1.29
  2. 심경, 신경의 오수혈 침자가 Mitochondrial Respiratory Chain Complexes에 미치는 영향 vol.37, pp.1, 2017, https://doi.org/10.14406/acu.2020.006