The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Yeonsan Ogye on monosodium iodoacetate-induced osteoarthritis in rats

연산오계(連山烏鷄)가 monosodium iodoacetate로 골관절염(骨關節炎)을 유도(誘導)한 랫드에 미치는 영향(影響)

  • Sim, Boo-Yong (Traditional and Biomedical Research Center(TBRC-RIC), Daejeon University) ;
  • Choi, Hak-Joo (Traditional and Biomedical Research Center(TBRC-RIC), Daejeon University) ;
  • Ji, Joong-Gu (Department of Oriental Health Care, College of Oriental Medicine, Daejeon University) ;
  • Kim, Dong-Hee (Traditional and Biomedical Research Center(TBRC-RIC), Daejeon University)
  • 심부용 (대전대학교 난치성 면역질환의 동서생명의학연구 지역혁신센터) ;
  • 최학주 (대전대학교 난치성 면역질환의 동서생명의학연구 지역혁신센터) ;
  • 지중구 (중부대학교 한방건강관리학과) ;
  • 김동희 (대전대학교 난치성 면역질환의 동서생명의학연구 지역혁신센터)
  • Received : 2017.02.10
  • Accepted : 2017.03.15
  • Published : 2017.03.30
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Abstract

Objective : The aim of this study is to investigate anti-arthritis activity using a korea's natural monument No. 265 designate 'Yeonsan-Ogye'. In this study, research by using extracts from different concentration of the Yeonsan-Ogye through an MIA-induced arthritis animal model was being conducted in vivo and scientifically verifying the efficacy of medicinal food. Methods : Yeonsan-Ogye was administered 500 mg/kg/day, 1000 mg/kg/day, 2000 mg/kg/day to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at $60mg/m{\ell}$. MMP-9, COMP, CTXII, calcitonin and glycosaminoglycan level in serum were measured by ELISA. The changes of relative hind paw weight bearing ratio by Incapacitance Test Meter and The cartilage of meniscus volume was examined and 3-D high-resolution reconstructions of the cartilage of meniscus were obtained using a Micro-CT system. Also, the histopathological analysis of knee was observed by H&E and safranin-O staining. Results : Production of MMP-9, COMP (all groups) and CTXII (500, 1000 mg/kg/day) level in serum was decreased, respectively, in comparison with control. The other way, production of calcitonin (500, 1000 mg/kg/day) and glycosaminoglycan (all groups) level in serum, Hind paw weight bearing ratio (all groups) was increased, espectively, in comparison with control. The cartilage of patella volume in micro-CT increased significantly. In addition, all groups showed a increase in the cartilage volume and proteoglycan. Conclusion : The results for Yeonsan-Ogye showed significant antiarthritis activity in serum and the cartilage. Therefore, it is thought to be that Yeonsan Ogye can be utilized as a variety of new korea medicie and health foods against arthritis diseases.

Keywords

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