식품과학과 산업 (Food Science and Industry)

한국식품과학회 (Korean Society of Food Science and Technology)
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항노로바이러스 천연물을 이용한 식품개발

Anti-norovirus activity of natural compounds and its potential in food application

  • 김연지 (고려대학교 생명과학대학 생명공학과) ;
  • 이정수 (식품의약품안전처 식품의약품안전평가원 미생물과) ;
  • 주인선 (식품의약품안전처 식품의약품안전평가원 미생물과) ;
  • 이성준 (고려대학교 생명과학대학 생명공학과)
  • Kim, Yeon-Ji (Department of Biotechnology, College of Life Sciences & Biotechnology, Korea University) ;
  • Lee, Jeong Su (Food Microbiology Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Joo, In Sun (Food Microbiology Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety) ;
  • Lee, Sung-Joon (Department of Biotechnology, College of Life Sciences & Biotechnology, Korea University)
  • 투고 : 2017.02.22
  • 심사 : 2017.03.08
  • 발행 : 2017.03.31
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초록

Control of food pathogens is critical in food safety field. Norovirus is one of the major causes of gastroenteritis and food poisoning worldwide, however, currently, there is not a vaccine or a specific drug available for its treatment. There are several methods to inactivate norovirus during food processing by chemical and physical treatments, however, the use of natural substance has been suggested as an optional strategy due to their safety and consumer preference. In this study supported by Ministry of Food and Drug Safety in Korea, we identified novel plant-derived substances with significant anti-norovirus activities. The aim of this project was to determine the antiviral activity of a wide range of natural substances, including plant-derived extracts and essential oils, using a norovirus surrogate system, human norovirus replicon-bearing cells, and mouse in vivo experiments. During the activity screening test, we identified novel anti-norovirus substances or oils using plaque assay with MNV-1. Six selected substances were formulated into an optimum mixture and used as an ingredient for salad sauce of which anti-novovirus activity was confirmed(pending for patent and paper submission). The potential application of selected natural substances as a metal surface sanitizer was also tested. Interestingly, the mixture of selected natural compounds showed a significant inhibitory effect against norovirus. These results suggest that these substances may be used as food ingredient with anti-norovirus antivity or components for surface sanitizers to prevent norovirus contamination.

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참고문헌

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