Archives of Craniofacial Surgery (대한두개안면성형외과학회지)

Korean Cleft Palate-Craniofacial Association (대한두개안면성형외과학회)
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Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study

  • Jung, Bok Ki (Department of Plastic and Reconstructive Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Lee, Won Jai (Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) ;
  • Kang, Eunhye (Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) ;
  • Ahn, Hyo Min (Department of Bioengineering, College of Engineering, Hanyang University) ;
  • Kim, Yong Oock (Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) ;
  • Rah, Dong Kyun (Institute for Human Tissue Restoration, Department of Plastic and Reconstructive Surgery, Yonsei University College of Medicine) ;
  • Yun, Chae-Ok (Department of Bioengineering, College of Engineering, Hanyang University) ;
  • Yun, In Sik (Department of Plastic and Reconstructive Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine)
  • Received : 2017.01.19
  • Accepted : 2017.02.24
  • Published : 2017.03.20
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Abstract

Background: Relaxin is a transforming growth factor ${\beta}1$ antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model. Methods: Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared. Results: Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group. Conclusion: Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.

Keywords

References

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