DOI QR코드

DOI QR Code

Analysis of Risk Factors for Conversion from Off-Pump to On-Pump Coronary Artery Bypass Graft

  • Lim, Junghyeon (Department of Thoracic and Cardiovascular Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Lee, Won Yong (Department of Thoracic and Cardiovascular Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Ra, Yong Joon (Department of Thoracic and Cardiovascular Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Jeong, Jae Han (Department of Thoracic and Cardiovascular Surgery, Chosun University Hospital, Chosun University College of Medicine) ;
  • Ko, Ho Hyun (Department of Thoracic and Cardiovascular Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine)
  • Received : 2016.02.05
  • Accepted : 2016.08.12
  • Published : 2017.02.05

Abstract

Background: Off-pump coronary artery bypass (OPCAB) is performed worldwide, but significant risks are associated with conversion to on-pump surgery. Therefore, we evaluated the composite outcomes between an OPCAB group and a conversion group. Methods: From January 2008 to December 2012, 100 consecutive patients underwent OPCAB at Hallym University Sacred Heart Hospital, of whom 84 underwent OPCAB without adverse events (OPCAB group), and 16 were converted to on-pump surgery (conversion group). Early morbidity, early and long-term mortality, and major adverse cardiac and cerebrovascular events (MACCEs) were the primary and long-term composite endpoints. Results: The mean follow-up period was $55{\pm}26months$, with 93% of the patients completing follow-up. The composite outcomes in the OPCAB and conversion groups were as follows: early morbidity, 2.3% versus 12.5%; early mortality, 4.7% versus 0%; long-term mortality, 14.3% versus 25.0%; and MACCEs, 14.3% versus 18.8%, respectively. No composite endpoints showed statistically significant differences. Preoperative acute myocardial infarction (AMI) was identified as an independent risk factor for conversion (p=0.025). Conclusion: The conversion group showed no statistically significant differences in early mortality and morbidity, MACCEs, or long-term mortality compared with the OPCAB group. The preoperative diagnosis of AMI was associated with an increased number of conversions to on-pump surgery.

Keywords

References

  1. Kolessov VI. Mammary artery-coronary artery anastomosis as method of treatment for angina pectoris. J Thorac Cardiovasc Surg 1967;54:535-44.
  2. Calafiore AM, Di Giammarco G, Teodori G, et al. Left anterior descending coronary artery grafting via left anterior small thoracotomy without cardiopulmonary bypass. Ann Thorac Surg 1996;61:1658-65. https://doi.org/10.1016/0003-4975(96)00187-7
  3. Subramanian VA, McCabe JC, Geller CM. Minimally invasive direct coronary artery bypass grafting: two-year clinical experience. Ann Thorac Surg 1997;64:1648-53. https://doi.org/10.1016/S0003-4975(97)01099-0
  4. Kaya K, Cavolli R, Telli A, et al. Off-pump versus on-pump coronary artery bypass grafting in acute coronary syndrome: a clinical analysis. J Cardiothorac Surg 2010;5:31. https://doi.org/10.1186/1749-8090-5-31
  5. Reeves BC, Ascione R, Caputo M, Angelini GD. Morbidity and mortality following acute conversion from off-pump to on-pump coronary surgery. Eur J Cardiothorac Surg 2006; 29:941-7. https://doi.org/10.1016/j.ejcts.2006.03.018
  6. Tabata M, Takanashi S, Horai T, Fukui T, Hosoda Y. Emergency conversion in off-pump coronary artery bypass grafting. Interact Cardiovasc Thorac Surg 2006;5:555-9. https://doi.org/10.1510/icvts.2006.128884
  7. Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. Circulation 2012;126:2020-35. https://doi.org/10.1161/CIR.0b013e31826e1058
  8. Cannon CP, Braunwald E. Non-ST-segment elevation acute coronary syndrome (non-ST-segment elevation myocardial infarction and unstable angina). In: Kasper DL, Fauci AS, Hauser SL, editors. Harrison's principles of internal medicine. 19th ed. New York (NY): McGraw-Hill Education; 2015. p. 1593-8.
  9. Chowdhury R, White D, Kilgo P, et al. Risk factors for conversion to cardiopulmonary bypass during off-pump coronary artery bypass surgery. Ann Thorac Surg 2012;93:1936-41. https://doi.org/10.1016/j.athoracsur.2012.02.051
  10. Hovakimyan A, Manukyan V, Ghazaryan S, Saghatelyan M, Abrahamyan L, Hovaguimian H. Predictors of emergency conversion to on-pump during off-pump coronary surgery. Asian Cardiovasc Thorac Ann 2008;16:226-30. https://doi.org/10.1177/021849230801600310
  11. Hattler B, Messenger JC, Shroyer AL, et al. Off-Pump coronary artery bypass surgery is associated with worse arterial and saphenous vein graft patency and less effective revascularization: results from the Veterans Affairs Randomized On/Off Bypass (ROOBY) trial. Circulation 2012;125:2827-35. https://doi.org/10.1161/CIRCULATIONAHA.111.069260
  12. Li Z, Amsterdam EA, Danielsen B, Hoegh H, Young JN, Armstrong EJ. Intraoperative conversion from off-pump to on-pump coronary artery bypass is associated with increased 30-day hospital readmission. Ann Thorac Surg 2014;98:16-22. https://doi.org/10.1016/j.athoracsur.2014.03.040
  13. Jin R, Hiratzka LF, Grunkemeier GL, Krause A, Page US 3rd. Aborted off-pump coronary artery bypass patients have much worse outcomes than on-pump or successful off-pump patients. Circulation 2005;112(9 Suppl):I332-7. https://doi.org/10.1161/CIRCULATIONAHA.104.489088
  14. Mukherjee D, Ahmed K, Baig K, Patel VM, Darzi A, Athanasiou T. Conversion and safety in off-pump coronary artery bypass: a system failure that needs re-emphasis. Ann Thorac Surg 2011;91:630-9. https://doi.org/10.1016/j.athoracsur.2010.10.031
  15. Mukherjee D, Rao C, Ibrahim M, et al. Meta-analysis of organ damage after conversion from off-pump coronary artery bypass procedures. Ann Thorac Surg 2011;92:755-61. https://doi.org/10.1016/j.athoracsur.2011.05.037
  16. Edgerton JR, Dewey TM, Magee MJ, et al. Conversion in off-pump coronary artery bypass grafting: an analysis of predictors and outcomes. Ann Thorac Surg 2003;76:1138-42. https://doi.org/10.1016/S0003-4975(03)00747-1
  17. Novitzky D, Baltz JH, Hattler B, et al. Outcomes after conversion in the Veterans Affairs randomized on versus off bypass trial. Ann Thorac Surg 2011;92:2147-54. https://doi.org/10.1016/j.athoracsur.2011.05.122
  18. Kim KB, Lim C, Ahn H, Yang JK. Intraaortic balloon pump therapy facilitates posterior vessel off-pump coronary artery bypass grafting in high-risk patients. Ann Thorac Surg 2001;71:1964-8. https://doi.org/10.1016/S0003-4975(01)02638-8

Cited by

  1. THE RESULTS OF AN AIMED INCOMPLETE MYOCARDIAL REVASCULARIZATION WITH LOW INVASIVE AND STANDARD TECHNICS OF CORONARY BYPASS vol.2018, pp.7, 2018, https://doi.org/10.15829/1560-4071-2018-7-47-52
  2. Long-term outcomes of coronary artery bypass surgery in young patients vol.2019, pp.11, 2017, https://doi.org/10.17116/hirurgia201911157
  3. Results of coronary artery bypass grafting in patients of different age groups vol.25, pp.2, 2017, https://doi.org/10.33529/angio2019213
  4. ANSiscope™: Can it be the Crystal Ball of Cardiac Anesthesia? vol.22, pp.1, 2017, https://doi.org/10.4103/aca.aca_9_18
  5. Conversion from Off to On-Pump Coronary Artery Bypass Grafting. Is it Avoidable? vol.12, pp.1, 2017, https://doi.org/10.7759/cureus.6791