DOI QR코드

DOI QR Code

Retinol, α-tocopherol, and selected minerals in breast milk of lactating women with full-term infants in South Korea

  • Kim, Hyesook (Department of Nutritional Science and Food Management, Ewha Womans University) ;
  • Jung, Byung-Mun (Maeil Asia Human Milk Research Center, Maeil Dairies Co., Ltd) ;
  • Lee, Bum-Noh (Maeil Asia Human Milk Research Center, Maeil Dairies Co., Ltd) ;
  • Kim, Yun-Je (Maeil Asia Human Milk Research Center, Maeil Dairies Co., Ltd) ;
  • Jung, Ji A (Maeil Asia Human Milk Research Center, Maeil Dairies Co., Ltd) ;
  • Chang, Namsoo (Department of Nutritional Science and Food Management, Ewha Womans University)
  • Received : 2016.08.30
  • Accepted : 2016.11.22
  • Published : 2017.02.01

Abstract

BACKGROUND/OBJECTIVES: This study was performed to measure fat-soluble vitamins and minerals in breast milk of Korean lactating mothers who exclusively breastfed their babies. SUBJECTS/METHODS: Breast milk samples were collected from 334 mothers. Concentrations of retinol and ${\alpha}$-tocopherol were analyzed by high performance liquid chromatography ultraviolet spectrometry while concentrations of minerals were measured by inductively coupled plasma optical emission spectrometry. RESULTS: Retinol and ${\alpha}$-tocopherol contents of breast milk were $39.58{\pm}19.64{\mu}g/dL$ and $0.23{\pm}0.13mg/dL$, respectively. Average sodium, potassium, calcium, phosphorus, and magnesium levels in breast milk were $11.11{\pm}5.16$, $38.56{\pm}9.01$, $27.87{\pm}6.10$, $13.56{\pm}3.30$, and $3.05{\pm}0.65mg/dL$, respectively. Contents of trace elements such as iron, zinc, copper, and manganese were $40.26{\pm}46.21$, $98.40{\pm}62.47$, $24.09{\pm}9.03$, and $0.90{\pm}1.63{\mu}g/dL$, respectively. Fat-soluble vitamin concentration was positively correlated with total fat in milk samples, but no significant differences were observed in levels of retinol, ${\alpha}$-tocopherol, or minerals based on whether or not lactating women were taking dietary supplements. CONCLUSIONS: Micronutrient contents of breast milk samples from Korean lactating women were comparable to those of other nations. Retinol and ${\alpha}$-tocopherol levels were correlated and also with total fat in breast milk.

Keywords

References

  1. Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors. Pediatr Clin North Am 2013;60:49-74. https://doi.org/10.1016/j.pcl.2012.10.002
  2. Isaacs EB, Fischl BR, Quinn BT, Chong WK, Gadian DG, Lucas A. Impact of breast milk on intelligence quotient, brain size, and white matter development. Pediatr Res 2010;67:357-62. https://doi.org/10.1203/PDR.0b013e3181d026da
  3. Roze JC, Darmaun D, Boquien CY, Flamant C, Picaud JC, Savagner C, Claris O, Lapillonne A, Mitanchez D, Branger B, Simeoni U, Kaminski M, Ancel PY. The apparent breastfeeding paradox in very preterm infants: relationship between breast feeding, early weight gain and neurodevelopment based on results from two cohorts, EPIPAGE and LIFT. BMJ Open 2012;2:e000834. https://doi.org/10.1136/bmjopen-2012-000834
  4. ESPGAN committee on nutrition. Guidelines on infant nutrition. III. Recommendations for infant feeding. Acta Paediatr Scand Suppl 1982;302:1-27.
  5. World Health Organization; Unicef. Global Strategy for Infant and Young Child Feeding. Geneva: World Health Organization; 2003.
  6. Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics 2012;129:e827-41. https://doi.org/10.1542/peds.2011-3552
  7. Department of Health (GB). Infant feeding recommendation [Internet]. London: Department of Health; 2003 [cited 2015 June 1]. Available from: http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/documents/digitalasset/dh_4096999.pdf.
  8. Ministry of Health and Welfare, Korea Center for Disease Prevention and Control; National Health Insurance Service (KR). Manual of Pediatric Physical Examination 2015. Cheongju: Korea Center for Disease Prevention and Control; 2015.
  9. Bai HS, Lee DH, Ahn HS. Nutrient intakes of infants according to feeding pattern at 2 month age. Korean J Nutr 1996;29:77-88.
  10. Ahn HS, Jeong JY. Ecological studies of maternal-infant Nutrition and feeding in urban low income areas: III. Infant's nutrient intakes and growth pattern. Korean J Community Nutr 1998;3:174-89.
  11. Kim ES, Kim SB, Lee DH. The yields of volume, thiamin and riboflavin from the milk of cesarian-section women, and their ingestion in infants. Korean J Nutr 1999;32:83-9.
  12. Han YH, Yon M, Han HS, Johnston KE, Tamura T, Hyun T. Zinc status and growth of Korean infants fed human milk, casein-based, or soy-based formula: three-year longitudinal study. Nutr Res Pract 2011;5:46-51. https://doi.org/10.4162/nrp.2011.5.1.46
  13. Shin PJ, Bae CW, Choi YM. A comparative study of red blood cell indices and anemia by feeding patterns. J Korean Pediatr Soc 1999;42:1104-10.
  14. Choi EH, Jung SH, Jun YH, Lee YJ, Park JY, You JS, Chang KJ, Kim SK. Iron deficiency anemia and vitamin D deficiency in breastfed infants. Korean J Pediatr Gastroenterol Nutr 2010;13:164-71. https://doi.org/10.5223/kjpgn.2010.13.2.164
  15. Kim YJ. Comparison of the serum vitamin D level between breastfed and formula-fed infants: several factors which can affect serum vitamin D concentration. Korean J Pediatr 2013;56:202-4. https://doi.org/10.3345/kjp.2013.56.5.202
  16. Jin HJ, Lee JH, Kim MK. The prevalence of vitamin D deficiency in iron-deficient and normal children under the age of 24 months. Blood Res 2013;48:40-5. https://doi.org/10.5045/br.2013.48.1.40
  17. Kang YS, Kim JH, Ahn EH, Yoo EG, Kim MK. Iron and vitamin D status in breastfed infants and their mothers. Korean J Pediatr 2015;58:283-7. https://doi.org/10.3345/kjp.2015.58.8.283
  18. Qian L, Wang B, Tang N, Zhang W, Cai W. Polymorphisms of SLC30A2 and selected perinatal factors associated with low milk zinc in Chinese breastfeeding women. Early Hum Dev 2012;88:663-8. https://doi.org/10.1016/j.earlhumdev.2012.01.011
  19. Nikniaz L, Mahdavi R, Gargari BP, Gayem Magami SJ, Nikniaz Z. Maternal body mass index, dietary intake and socioeconomic status: differential effects on breast milk zinc, copper and iron content. Health Promot Perspect 2011;1:140-6.
  20. Lonnerdal B. Effects of maternal dietary intake on human milk composition. J Nutr 1986;116:499-513. https://doi.org/10.1093/jn/116.4.499
  21. Chierici R, Saccomandi D, Vigi V. Dietary supplements for the lactating mother: influence on the trace element content of milk. Acta Paediatr Suppl 1999;88:7-13. https://doi.org/10.1111/j.1651-2227.1999.tb01146.x
  22. Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention. Korea Health Statistics 2014: Korea National Health and Nutrition Examination Survey (KNHANES VI-2). Cheongju: Korea Centers for Disease Control and Prevention; 2015.
  23. Chang N, Jung JA, Kim H, Jo A, Kang S, Lee SW, Yi H, Kim J, Yim JG, Jung BM. Macronutrient composition of human milk from Korean mothers of full term infants born at 37-42 gestational weeks. Nutr Res Pract 2015;9:433-8. https://doi.org/10.4162/nrp.2015.9.4.433
  24. Lee SW, In YM, Choi JC, Yang HJ. Determination of the fatty acid and vitamin content of Korean human milk during lactation period. J Korean Soc Food Sci Anim Resour 1997;17:17-25.
  25. Kim ES. Vitamin A intake of exclusively breast-fed infants in Cheongju and Anseong areas. Korean J Nutr 2003;36:743-8.
  26. Kim Y, English C, Reich P, Gerber LE, Simpson KL. Vitamin A and carotenoids in human milk. J Agric Food Chem 1990;38:1930-3. https://doi.org/10.1021/jf00100a011
  27. Lee JS, Kim ES. Study on vitamin E intake of exclusively breast-fed infants. Korean J Nutr 1998;31:1440-5.
  28. Bates CJ. Vitamin A in pregnancy and lactation. Proc Nutr Soc 1983;42:65-79. https://doi.org/10.1079/PNS19830008
  29. Tijerina-Saenz A, Innis SM, Kitts DD. Antioxidant capacity of human milk and its association with vitamins A and E and fatty acid composition. Acta Paediatr 2009;98:1793-8. https://doi.org/10.1111/j.1651-2227.2009.01437.x
  30. Quiles JL, Ochoa JJ, Ramirez-Tortosa MC, Linde J, Bompadre S, Battino M, Narbona E, Maldonado J, Mataix J. Coenzyme Q concentration and total antioxidant capacity of human milk at different stages of lactation in mothers of preterm and full-term infants. Free Radic Res 2006;40:199-206. https://doi.org/10.1080/10715760500404805
  31. Schweigert FJ, Bathe K, Chen F, Buscher U, Dudenhausen JW. Effect of the stage of lactation in humans on carotenoid levels in milk, blood plasma and plasma lipoprotein fractions. Eur J Nutr 2004;43:39-44. https://doi.org/10.1007/s00394-004-0439-5
  32. Debier C. Vitamin E during pre- and postnatal periods. Vitam Horm 2007;76:357-73.
  33. Lima MS, Dimenstein R, Ribeiro KD. Vitamin E concentration in human milk and associated factors: a literature review. J Pediatr (Rio J) 2014;90:440-8. https://doi.org/10.1016/j.jped.2014.04.006
  34. Choi KH, Moon J, Keum HK, Kim ES. Milk, sodium and potassium intaken of breastfed infants during lactation. Korean J Nutr 1995;28:612-9.
  35. Lee JS, Lee YN, Kim ES. Study on sodium and potassium intakes of breast-fed infants during the first 5 months of lactation. Korean J Nutr 2001;34:23-9.
  36. Yamawaki N, Yamada M, Kan-no T, Kojima T, Kaneko T, Yonekubo A. Macronutrient, mineral and trace element composition of breast milk from Japanese women. J Trace Elem Med Biol 2005;19:171-81. https://doi.org/10.1016/j.jtemb.2005.05.001
  37. Qian J, Chen T, Lu W, Wu S, Zhu J. Breast milk macro- and micronutrient composition in lactating mothers from suburban and urban Shanghai. J Paediatr Child Health 2010;46:115-20. https://doi.org/10.1111/j.1440-1754.2009.01648.x
  38. Ministry of Health and Welfare (KR); The Korean Nutrition Society. Dietary Reference Intakes for Koreans 2015. Sejong: Ministry of Health and Welfare; 2016. p.659-66.
  39. Sandor Z. Equivalency law in the metal requirement of the living organisms. Acta Aliment 1998;27:389-95.
  40. Koo JO, Choi K. A longitudinal study of calcium and phosphorus intakes of Korean infants from 1 to 3 months in breast-fed vs formula-fed infants. Korean J Community Nutr 2000;5:273-9.
  41. Kim ES, Keum HK. Protein, Ca, Mg and P intakes of breast-fed infants during lactation. Korean J Nutr 2003;36:942-9.
  42. Kim ES, Cho KH. Iron, copper and zinc levels in human milk and estimated intake of the minerals by breast-fed infants during the early lactation. J East Asian Soc Diet Life 2004;14:27-33.
  43. Moon SJ, Kang JS, Lee MJ, Lee JH, Ahn HS. A longitudinal study of micro-mineral concentration in human milk. Korean J Nutr 1995;28:620-8.
  44. Choi YK, Kim JM, Lee JE, Cho MS, Kang BS, Choi H, Kim Y. Association of maternal diet with zinc, copper, and iron concentrations in transitional human milk produced by Korean mothers. Clin Nutr Res 2016;5:15-25. https://doi.org/10.7762/cnr.2016.5.1.15
  45. Domellof M, Lonnerdal B, Dewey KG, Cohen RJ, Hernell O. Iron, zinc, and copper concentrations in breast milk are independent of maternal mineral status. Am J Clin Nutr 2004;79:111-5. https://doi.org/10.1093/ajcn/79.1.111
  46. Celada A, Busset R, Gutierrez J, Herreros V. No correlation between iron concentration in breast milk and maternal iron stores. Helv Paediatr Acta 1982;37:11-6.
  47. Barkova EN, Nazarenko EV, Zhdanova EV. Diurnal variations in qualitative composition of breast milk in women with iron deficiency. Bull Exp Biol Med 2005;140:394-6. https://doi.org/10.1007/s10517-005-0500-2
  48. Lubetzky R, Littner Y, Mimouni FB, Dollberg S, Mandel D. Circadian variations in fat content of expressed breast milk from mothers of preterm infants. J Am Coll Nutr 2006;25:151-4. https://doi.org/10.1080/07315724.2006.10719526
  49. Daly SE, Di Rosso A, Owens RA, Hartmann PE. Degree of breast emptying explains changes in the fat content, but not fatty acid composition, of human milk. Exp Physiol 1993;78:741-55. https://doi.org/10.1113/expphysiol.1993.sp003722

Cited by

  1. Human Milk and Allergic Diseases: An Unsolved Puzzle vol.9, pp.8, 2017, https://doi.org/10.3390/nu9080894
  2. Relationship between the dietary intake, serum, and breast milk concentrations of vitamin A and vitamin E in a cohort of women over the course of lactation pp.17408695, 2019, https://doi.org/10.1111/mcn.12772
  3. Breast Milk Content of Vitamin A and E from Early- to Mid-Lactation Is Affected by Inadequate Dietary Intake in Brazilian Adult Women vol.11, pp.9, 2017, https://doi.org/10.3390/nu11092025
  4. A Study on the Relationship of Fat Content in Human Milk on Carotenoids Content and Fatty Acid Compositions in Korea vol.11, pp.9, 2017, https://doi.org/10.3390/nu11092072
  5. A Comparison of Vitamin and Lutein Concentrations in Breast Milk from Four Asian Countries vol.12, pp.6, 2017, https://doi.org/10.3390/nu12061794