셀메드 (CELLMED)

  • 제7권1호
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  • Pages.4.1-4.4
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  • 2017
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  • 3022-6805(pISSN)
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  • 3022-6791(eISSN)
셀메드 세포교정의약학회 (Cellmed Orthocellular Medicine and Pharmaceutical Association)
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Sogeunjung-tang improves depressive-like behavior decreased by forced-swimming test

  • Jeong, Hyun-Ja (Department of Food Science & Technology, Hoseo University) ;
  • Moon, A Rim (Department of Food Science & Technology, Hoseo University) ;
  • Kim, Na-Hyung (Department of Pharmacology, College of Korean Medicine, Kyung Hee University) ;
  • Chung, Cha-kwon (Department of Food & Nutrition, Hallym University)
  • 투고 : 2016.11.16
  • 심사 : 2017.02.03
  • 발행 : 2017.02.28
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초록

Sogeunjung-tang (S-tang) is a traditional Korean medicine that has been used for the therapy of anxiety disorder in a variety of clinical situations. However, no study has investigated this effect. The aim of this study was to investigate the effectiveness of S-tang for reducing depression in animal model. The anti-depressant effect of S-tang was investigated in ICR mice by using forced swimming test (FST). After FST, we analyzed the blood biochemical parameters from blood. The immobility time was significantly decreased in the S-tang oral administration or pharmaceutical acupuncture group compared with the control group at 14 days (p < 0.05). The anti-depressant effect of S-tang was higher than that of fluoxetine (a classical anti-depressant). S-tang or fluoxetine significantly decreased the creatine kinase and lactate dehydrogenase level compared with the control group (p < 0.05) but not glucose, protein, and blood urea nitrogen level. Further investigation of S-tang as a potential pharmacologic agent in the management of depression related anxiety is warranted.

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