Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Alterations of Cortical Folding Patterns in Patients with Bipolar I Disorder : Analysis of Local Gyrification Index

제1형 양극성장애 환자에서 대뇌피질 주름 패턴의 변형 : Local Gyrification Index 분석

  • Lee, Junyong (Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine) ;
  • Han, Kyu-Man (Department of Psychiatry, Korea University Ansan Hospital, Korea University College of Medicine) ;
  • Won, Eunsoo (Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine) ;
  • Lee, Min-Soo (Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine) ;
  • Ham, Byung-Joo (Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine)
  • 이준용 (고려대학교 안암병원 정신건강의학과) ;
  • 한규만 (고려대학교 안산병원 정신건강의학과) ;
  • 원은수 (고려대학교 안암병원 정신건강의학과) ;
  • 이민수 (고려대학교 안암병원 정신건강의학과) ;
  • 함병주 (고려대학교 안암병원 정신건강의학과)
  • Received : 2017.09.07
  • Accepted : 2017.10.24
  • Published : 2017.11.30
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Abstract

Objectives Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. Several studies have suggested altered local gyrification in patients with bipolar I disorder (BD-I). The purpose of the present study was to investigate the alterations in the cortical gyrification of whole brain cortices in patients with BD-I. Methods Twenty-two patients with BD-I and age and sex-matched 22 healthy controls (HC) were included in this study. All participants underwent T1-weighted structural magnetic resonance imaging (MRI). The local gyrification index (LGI) of 66 cortical regions were analyzed using the FreeSurfer (Athinoula A. Martinos Center for Biomedical Imaging). One-way analysis of covariance (ANCOVA) was used to analyze the difference of LGI values between two groups adjusting for age and sex as covariates. Results The patients with BD-I showed significant hypogyria in the left pars opercularis (uncorrected-p = 0.049), the left rostral anterior cingulate gyrus (uncorrected-p = 0.012), the left caudal anterior cingulate gyrus (uncorrected-p = 0.033). However, these findings were not significant after applying the multiple comparison correction. Severity or duration of illness were not significantly correlated with LGI in the patients with BD-I. Conclusions Our results of lower LGI in the anterior cingulate cortex and the ventrolateral prefrontal cortex in the BD-I group implicate that altered cortical gyrification in neural circuits involved in emotion-processing may contribute to pathophysiology of BD-I.

Keywords

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