Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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The Alteration of % Carbohydrate-Deficient Transferrin and Gamma-Glutamyl Transferase Levels of Alcohol-Dependent Inpatients according to Age and Sex

알코올의존으로 입원한 환자에서 나이와 성별에 따른 퍼센트 탄수화물-결핍트랜스페린과, 감마-글루타밀전이효소 변화 양상의 차이

  • Jin, Gyo-Sik (Department of Neuropsychiatry, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Yi, Jung Seo (Department of Neuropsychiatry, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Lee, Boung Chul (Department of Neuropsychiatry, Hangang Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Jee Wook (Department of Neuropsychiatry, Dongtan Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Choi, Ihn-Geun (Department of Neuropsychiatry, Kangnam Sacred Heart Hospital, Hallym University College of Medicine)
  • 진교식 (한림대학교 의과대학 강남성심병원 정신건강의학교실) ;
  • 이중서 (한림대학교 의과대학 강남성심병원 정신건강의학교실) ;
  • 이병철 (한림대학교 의과대학 한강성심병원 정신건강의학교실) ;
  • 김지욱 (한림대학교 의과대학 동탄성심병원 정신건강의학교실) ;
  • 최인근 (한림대학교 의과대학 강남성심병원 정신건강의학교실)
  • Received : 2017.09.14
  • Accepted : 2017.10.23
  • Published : 2017.11.30
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Abstract

Objectives This study sought to investigate the relationship between age, sex and alterations in levels of % carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl transferase (GGT) in patients admitted with alcohol dependence. Methods The study retrospectively enrolled 187 patients who were diagnosed with alcohol dependence according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (DSM-IV) and were admitted into a closed ward in Hallym University Hangang Sacred Heart Hospital from 2009 to 2012 and Hallym University Kangnam Sacred Heart Hospital from 2012 to 2017. Demographic factors (age, sex) and biochemical markers [%CDT, GGT, mean corpuscular volume (MCV), aspartate transferase (AST), alanine transferase (ALT)] were collected by reviewing medical records. Alterations in the levels of %CDT and GGT in different groups for each demographic factor were compared after correcting for confounding variables (age, initial %CDT, GGT, MCV, AST, ALT). Results Decreased %CDT and GGT were observed during the period of abstinence after admission. The normalization period for %CDT increased with age, while the normalization period for GGT was longer in female patients. Conclusions These results suggest that alcohol-dependent patients that vary in age have different alterations in %CDT, while different sexes have different alterations in GGT. Age and sex can be potential indicators of treatment response after abstinence in patients with alcohol dependence. Further studies are needed to evaluate the relationship between these factors with regards to physiological and hematological changes in alcohol dependence.

Keywords

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