Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Serum neuron specific enolase is increased in pediatric acute encephalitis syndrome

  • Pratamastuti, Dian (College of Medicine, Airlangga University) ;
  • Gunawan, Prastiya Indra (Division of Pediatric Neurology, Department of Pediatrics, College of Medicine, Airlangga University, Soetomo Hospital) ;
  • Saharso, Darto (Division of Pediatric Neurology, Department of Pediatrics, College of Medicine, Airlangga University, Soetomo Hospital)
  • 투고 : 2016.08.12
  • 심사 : 2017.01.19
  • 발행 : 2017.09.15
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초록

Purpose: This study aimed to investigate whether serum neuron-specific enolase (NSE) was expressed in acute encephalitis syndrome (AES) that causes neuronal damage in children. Methods: This prospective observational study was conducted in the pediatric neurology ward of Soetomo Hospital. Cases of AES with ages ranging from 1 month to 12 years were included. Cases that were categorized as simple and complex febrile seizures constituted the non-AES group. Blood was collected for the measurement of NSE within 24 hours of hemodynamic stabilization. The median NSE values of both groups were compared by using the Mann-Whitney U test. All statistical analyses were performed with SPSS version 12 for Windows. Results: In the study period, 30 patients were enrolled. Glasgow Coma Scale mostly decreased in the AES group by about 40% in the level ${\leq}8$. All patients in the AES group suffered from status epilepticus and 46.67% of them had body temperature >$40^{\circ}C$. Most of the cases in the AES group had longer duration of stay in the hospital. The median serum NSE level in the AES group was 157.86 ng/mL, and this value was significantly higher than that of the non-AES group (10.96 ng/mL; P<0.05). Conclusion: AES cases showed higher levels of serum NSE. These results indicate that serum NSE is a good indicator of neuronal brain injury.

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참고문헌

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피인용 문헌

  1. Correlation of serum S100B levels with brain magnetic resonance imaging abnormalities in children with status epilepticus vol.62, pp.7, 2017, https://doi.org/10.3345/kjp.2018.07017