References
- Ahmad, A., Maitah, M.Y., Ginnebaugh, K.R., Li, Y., Bao, B., Gadgeel, S.M., and Sarkar, F.H. (2013). Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs. J. Hematol. Oncol. 6, 77. https://doi.org/10.1186/1756-8722-6-77
- Chen, H., Luo, Z., Dong, L., Tan, Y., Yang, J., Feng, G., Wu, M., Li, Z., and Wang, H. (2013). CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival. PLoS One 8, e56878. https://doi.org/10.1371/journal.pone.0056878
- Chen, Y., Henson, E.S., Xiao, W., Huang, D., McMillan-Ward, E.M., Israels, S.J., and Gibson, S.B. (2016). Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia. Autophagy 12, 1029-1046. https://doi.org/10.1080/15548627.2016.1164357
- Chien, C.S., Wang, M.L., Chu, P.Y., Chang, Y.L., Liu, W.H., Yu, C.C., Lan, Y.T., Huang, P.I., Lee, Y.Y., Chen, Y.W., et al. (2015). Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State. Cancer Res. 75, 2553-2565. https://doi.org/10.1158/0008-5472.CAN-14-2215
- Cho, B., Lim, Y., Lee, D.Y., Park S,Y., Lee, H., Kim, W.H., Yang, H., Bang, Y.J., and Jeoung, D.I. (2002). Identification and characterization of a novel cancer/testis antigen gene CAGE. Biochem. Biophys. Res. Commun. 292, 715-726. https://doi.org/10.1006/bbrc.2002.6701
- Cho, Y.H., Han, K.M., Kim, D., Lee, J., Lee, S.H., Choi, K.W., Kim, J., and Han, Y.M. (2014). Autophagy regulates homeostasis of pluripotency-associated proteins in hESCs. Stem Cells 32, 424-435. https://doi.org/10.1002/stem.1589
- Chung, H.J., Choi, Y.E., Kim, E.S., Han, Y.H., Park, M.J., and Bae, I.H. (2015). miR-29b attenuates tumorigenicity and stemness maintenance in human glioblastoma multiforme by directly targeting BCL2L2. Oncotarget 6, 18429-18444. https://doi.org/10.18632/oncotarget.4384
- Dogan, I., Kawabata, S., Bergbower, E., Gills, J.J., Ekmekci, A., Wilson, W., Rudin, C.M., and Dennis, P.A. (2014). SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines. Lung Cancer 85, 1-6. https://doi.org/10.1016/j.lungcan.2014.03.021
- Du, J., Liu, S., He, J., Liu, X., Qu, Y., Yan, W., Fan, J., Li, R., Xi, H., Fu, W., et al. (2015). MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma. Oncotarget 6, 14993-15007. https://doi.org/10.18632/oncotarget.3802
- Goulielmaki, M., Koustas, E., Moysidou, E., Vlassi, M., Sasazuki, T., Shirasawa, S., Zografos, G., Oikonomou, E., and Pintzas, A. (2016). BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. Oncotarget 7, 9188-9221. https://doi.org/10.18632/oncotarget.6942
- He, C., Dong, X., Zhai, B., Jiang, X., Dong, D., Li, B., Jiang, H., Xu, S., and Sun, X. (2015). MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway. Oncotarget 6, 28867-28881. https://doi.org/10.18632/oncotarget.4814
- Iwata, T., Fujita, T., Hirao, N., Matsuzaki, Y., Okada, T, Mochimaru, H., Susumu, N., Matsumoto, E., Sugano, K., Yamashita, N., et al. (2005). Frequent immune responses to a cancer/testis antigen, CAGE, in patients with microsatellite instability-positive endometrial cancer. Clin. Cancer Res. 11, 3949-3957. https://doi.org/10.1158/1078-0432.CCR-04-1702
- Jaganathan, S., Malek, E., Vallabhapurapu, S., Vallabhapurapu, S., and Driscoll, J.J. (2014). Bortezomib induces AMPK-dependent autophagosome formation uncoupled from apoptosis in drug resistant cells. Oncotarget 5, 12358-12370. https://doi.org/10.18632/oncotarget.2590
- Jiang, J., Li, Z., Yu, C., Chen, M., Tian, S., and Sun, C. (2015). MiR-1181 inhibits stem cell-like phenotypes and suppresses SOX2 and STAT3 in human pancreatic cancer. Cancer Lett. 356, 962-970. https://doi.org/10.1016/j.canlet.2014.11.007
- Kim, Y., Park, H., Park, D., Lee, Y.S., Choe, J., Hahn, J.H., Lee, H., Kim, Y.M., and Jeoung, D. (2010). Cancer/testis antigen CAGE exerts negative regulation on p53 expression through HDAC2 and confers resistance to anti-cancer drugs. J. Biol. Chem. 285, 25957-25968. https://doi.org/10.1074/jbc.M109.095950
- Kim, Y., Park, D., Kim, H., Choi, M., Lee, H., Lee, Y.S., Choe, J., Kim, Y.M., and Jeoung, D. (2013). miR-200b and cancer/testis antigen CAGE form a feedback loop to regulate the invasion and tumorigenic and angiogenic responses of a cancer cell line to microtubule-targeting drugs. J. Biol. Chem. 288, 36502-36518. https://doi.org/10.1074/jbc.M113.502047
- Kim, Y., Kim, H., Park, H., Park, D., Lee, H., Lee, Y.S., Choe, J., Kim, Y.M., and Jeoung, D. (2014). miR-326-Histone Deacetylase-3 feedback loop regulates the invasion and tumorigenic and angiogenic response to anti-cancer drugs. J. Biol. Chem. 289, 28019-28039. https://doi.org/10.1074/jbc.M114.578229
- Kim, Y., Kim, H., Park, D., Han, M., Lee, H., Lee, Y.S., Choe, J., Kim, Y.M., and Jeoung D. (2016). miR-217 and CAGE form feedback loop and regulates the response to anti-cancer drugs through EGFR and HER2. Oncotarget 7, 10297-10321. https://doi.org/10.18632/oncotarget.7185
- Liggins, A.P., Lim, S.H., Soilleux, E.J., Pulford, K., and Banham, A.H. (2010). A panel of cancer-testis genes exhibiting broad-spectrum expression in haematological malignancies. Cancer Immun. 10, 8.
- Liu, K., Lin, B., Zhao, M., Yang, X., Chen, M., Gao, A., Liu, F., Que, J., and Lan, X. (2013). The multiple roles for Sox2 in stem cell maintenance and tumorigenesis. Cell Signal. 25, 1264-1271. https://doi.org/10.1016/j.cellsig.2013.02.013
- Lopez-Bertoni, H., Lal, B., Li, A., Caplan, M., Guerrero-Cazares, H., Eberhart, C.G., Quinones-Hinojosa, A., Glas, M., Scheffler, B., Laterra, J., et al. (2015). DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2. Oncogene 34, 3994-4004. https://doi.org/10.1038/onc.2014.334
- Lu, Y.X., Yuan, L., Xue, X.L., Zhou, M., Liu, Y., Zhang, C., Li, J.P., Zheng, L., Hong, M., and Li, X.N. (2014). Regulation of colorectal carcinoma stemness, growth, and metastasis by an miR-200c-Sox2-negative feedback loop mechanism. Clin. Cancer Res. 20, 2631-2642. https://doi.org/10.1158/1078-0432.CCR-13-2348
- Luo, W., Li, S., Peng, B., Ye, Y., Deng, X., and Yao, K. (2013). Embryonic stem cells markers SOX2, OCT4 and Nanog expression and their correlations with epithelial-mesenchymal transition in nasopharyngeal carcinoma. PLoS One 8, e56324. https://doi.org/10.1371/journal.pone.0056324
- Ma, K., Pan, X., Fan, P., He, Y., Gu, J., Wang, W., Zhang, T., Li, Z., and Luo, X. (2014). Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells. Mol. Cancer 13, 118. https://doi.org/10.1186/1476-4598-13-118
- Ojha, R., Jha, V., Singh, S.K., and Bhattacharyya, S. (2014). Autophagy inhibition suppresses the tumorigenic potential of cancer stem cell enriched side population in bladder cancer. Biochim. Biophys. Acta. 1842, 2073-2086. https://doi.org/10.1016/j.bbadis.2014.07.007
- Ojha, R., Singh, S.K., and Bhattacharyya, S. (2016). JAK-mediated autophagy regulates stemness and cell survival in cisplatin resistant bladder cancer cells. Biochim. Biophys. Acta 1860, 2484-2497. https://doi.org/10.1016/j.bbagen.2016.07.021
- Ozen, M., Karatas, O.F., Gulluoglu, S., Bayrak, O.F., Sevli, S., Guzel, E., Ekici, I.D., Caskurlu, T., Solak, M., Creighton, C.J., et al. (2015). Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression. Cancer Invest. 33, 251-258. https://doi.org/10.3109/07357907.2015.1025407
- Pan, B., Feng, B., Chen, Y., Huang, G., Wang, R., Chen, L., and Song, H. (2015). MiR-200b regulates autophagy associated with chemoresistance in human lung adenocarcinoma. Oncotarget 6, 32805-32820. https://doi.org/10.18632/oncotarget.5352
- Park, S., Han, S., Choi, I., Kim, B., Park, S.P., Joe, E.H., and Suh, Y.H. (2016). Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy. PLoS One 11, e0163029. https://doi.org/10.1371/journal.pone.0163029
- Por, E., Byun, H.J., Lee, E.J., Lim, J.H., Jung, S.Y., Park, I., Kim, Y.M., Jeoung, D.I., and Lee, H. (2010). The cancer/testis antigen CAGE with oncogenic potential stimulates cell proliferation by up-regulating cyclins D1 and E in an AP-1- and E2F-dependent manner. J. Biol. Chem. 285, 14475-14485. https://doi.org/10.1074/jbc.M109.084400
- Rybak, A.P., and Tang, D. (2013). SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells. Cell Signal 25, 2734-2742. https://doi.org/10.1016/j.cellsig.2013.08.041
- Shankar, S., Nall, D., Tang, S.N., Meeker, D., Passarini, J., Sharma, J., and Srivastava, R.K. (2011). Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PLoS One 6, e16530. https://doi.org/10.1371/journal.pone.0016530
- Song, Y.J., Zhang, S.S., Guo, X.L., Sun, K., Han, Z.P., Li, R., Zhao, Q.D., Deng, W.J., Xie, X.Q., Zhang, J.W., et al. (2013). Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment. Cancer Lett. 339, 70-81. https://doi.org/10.1016/j.canlet.2013.07.021
- Su, Y.C., Davuluri, G.V., Chen, C.H., Shiau, D.C., Chen, C.C., Chen, C.L., Lin, Y.S., and Chang, C.P. (2016). Galectin-1-Induced Autophagy Facilitates Cisplatin Resistance of Hepatocellular Carcinoma. PLoS One 11, e0148408. https://doi.org/10.1371/journal.pone.0148408
- Tang, M.C., Wu, M.Y., Hwang, M.H., Chang, Y.T., Huang, H.J., Lin, A.M., and Yang, J.C. (2015). Chloroquine enhances gefitinib cytotoxicity in gefitinib-resistant nonsmall cell lung cancer cells. PLoS One 10, e0119135. https://doi.org/10.1371/journal.pone.0119135
- Tellez, C.S., Juri, D.E., Do, K., Bernauer, A.M., Thomas, C.L., Damiani, L.A., Tessema, M., Leng, S., and Belinsky, S.A. (2011). EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res. 71, 3087-3097. https://doi.org/10.1158/0008-5472.CAN-10-3035
- Valverde, A., Penarando, J., Canas, A., Lopez-Sanchez, L.M., Conde, F., Hernandez, V., Peralbo, E., Lopez-Pedrera, C., de la Haba-Rodriguez, J., Aranda, E., et al. (2015). Simultaneous inhibition of EGFR/VEGFR and cyclooxygenase-2 targets stemness-related pathways in colorectal cancer cells. PLoS One 10, e0131363 https://doi.org/10.1371/journal.pone.0131363
- Wei, M.F., Chen, M.W., Chen, K.C., Lou, P.J., Lin, S.Y., Hung, S.C., Hsiao, M., Yao, C.J., and Shieh, M.J. (2014). Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells. Autophagy 10, 1179-1192. https://doi.org/10.4161/auto.28679
- Xiong, B., Ma, L., Hu, X., Zhang, C., and Cheng, Y. (2104). Characterization of side population cells isolated from the colon cancer cell line SW480. Int. J. Oncol. 45, 1175-1183. https://doi.org/10.3892/ijo.2014.2498
- Xu, S.W., Law, B.Y., Mok, S.W., Leung, E.L., Fan, X.X., Coghi, P.S., Zeng, W., Leung, C.H., Ma, D.L., Liu, L., et al. (2016). Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol. Int. J. Oncol. 49, 1576-1588. https://doi.org/10.3892/ijo.2016.3644
- Yang, J., Liao, D., Chen, C., Liu, Y., Chuang, T.H., Xiang, R., Markowitz, D., Reisfeld, R.A., and Luo, Y. (2013). Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway. Stem Cells 31, 248-258. https://doi.org/10.1002/stem.1281
- Yang, M.C., Wang, H.C., Hou, Y.C., Tung, H.L., Chiu, T.J., and Shan, Y.S. (2015) Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine. Mol. Cancer 14, 179. https://doi.org/10.1186/s12943-015-0449-3
- Yang, P., Huo, Z., Liao, H., and Zhou, Q. (2015) Cancer/testis antigens trigger epithelial-mesenchymal transition and genesis of cancer stem-like cells. Curr. Pharm. Des. 21, 1292-1300. https://doi.org/10.2174/1381612821666141211154707
- Yin, B., Zeng, Y., Liu, G., Wang, X., Wang, P., and Song, Y. (2014) MAGE-A3 is highly expressed in a cancer stem cell-like side population of bladder cancer cells. Int. J. Clin. Exp. Pathol. 7, 2934-2941.
- Zhen, Q., Liu, J., Gao, L., Liu, J., Wang, R., Chu, W., Zhang, Y., Tan, G., Zhao, X., and Lv, B. (2015) MicroRNA-200a targets EGFR and c-Met to inhibit migration, invasion, and gefitinib resistance in non-small cell lung cancer. Cytogenet. Genome Res. 146, 1-8. https://doi.org/10.1159/000434741
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