Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Epigenetic Regulation of Axon Regeneration after Neural Injury

  • Shin, Jung Eun (The Research Institute of Basic Sciences, Seoul National University) ;
  • Cho, Yongcheol (Department of Life Sciences, Korea University)
  • Received : 2016.12.22
  • Accepted : 2017.01.23
  • Published : 2017.01.31
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Abstract

When peripheral axons are damaged, neuronal injury signaling pathways induce transcriptional changes that support axon regeneration and consequent functional recovery. The recent development of bioinformatics techniques has allowed for the identification of many of the regeneration-associated genes that are regulated by neural injury, yet it remains unclear how global changes in transcriptome are coordinated. In this article, we review recent studies on the epigenetic mechanisms orchestrating changes in gene expression in response to nerve injury. We highlight the importance of epigenetic mechanisms in discriminating efficient axon regeneration in the peripheral nervous system and very limited axon regrowth in the central nervous system and discuss the therapeutic potential of targeting epigenetic regulators to improve neural recovery.

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References

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