Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Systematic Review of Hominis Placenta Pharmacopuncture in English and Korean Literature

  • Ryoo, Dek-Woo (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Kim, Hong-Guk (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Kim, Sung-Jin (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Baek, Seung-Won (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Jeong, Seong-Mok (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Yoon, Jin-Young (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Lee, Chang-Hee (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Goo, Bon-Hyuk (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Kim, Min-Jeong (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Park, Yeon-Cheol (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Baek, Yong-Hyeon (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Nam, Sang-Soo (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong) ;
  • Seo, Byung-Kwan (Department of Acupuncture and Moxibustion Medicine, Kyung Hee University Hospital at Gangdong)
  • Received : 2017.07.25
  • Accepted : 2017.08.23
  • Published : 2017.11.30
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Abstract

Background: Hominis placenta (HP) is used in Korean medicine to tonify qi and blood, and enrich yin and tonify yang. HP has been reported to have therapeutic effects. Methods: A survey of international and Korean electronic databases was conducted using the search terms "hominis placenta pharmacopuncture" and "hominis placenta extract". The search was limited to material published up to May 31, 2017. Results: A total of 83 studies were included in this systematic review: 50 were clinical studies, 25 were basic studies, and 8 were other types of study. Among clinical studies, the most frequently treated disease groups were musculoskeletal diseases and nervous system diseases. In vitro studies were conducted mainly on anti-inflammatory, analgesic, and anti-cell necrosis models. Most of the in vivo studies were performed in rheumatoid arthritis or diabetic complications models. Conclusion: HP pharmacopuncture has effects in the treatment of various diseases. Further large-scale randomized controlled trials are needed to improve the level of evidence for HP pharmacopuncture. It would be helpful if future in vitro and in vivo studies could identify the mechanism of action of HP pharmacopuncture.

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References

  1. Shibasaki T, Odagiri E, Shizume K, Ling N. Corticotropin-releasing factor-like activity in human placental extracts. J Clin Endocrinol Metab 1982;55:384-386. https://doi.org/10.1210/jcem-55-2-384
  2. Tonello G, Dandlio M, Zaccarelli N, Sottofattori E, Mazzei M, Balbi A. Characterization and quantitation of the active polynucleotide fraction (PDRN) from human placenta, a tissue repair stimulating agent. J Pharm Biomed Anal 1996;14:1555-1560. https://doi.org/10.1016/0731-7085(96)01788-8
  3. Angelucci C, Lama G, Sica G. The growth of malignant and nonmalignant human cells is modulated by a human placental extract. Anticancer Res 1999;19:429-436.
  4. Togashi S, Takahashi N, Iwama M, Watanabe S, Tamagawa K, Fukui T. Antioxidative collagen-derived peptides in human-placenta extract. Placenta 2002;23:497-502. https://doi.org/10.1053/plac.2002.0833
  5. Datta P, Bhattacharyya D. Spectroscopic and chromatographic evidence of NADPH in human placental extract used as wound healer. J Pharm Biomed Anal 2004;34:1091-1098. https://doi.org/10.1016/S0731-7085(03)00654-X
  6. Choi JY, Oh DS, Jung HJ, Choi SM, Jung SK. Hominis placental pharmacoacupuncture, a promising asthma therapy. Korean J Acupunct 2008;28:87-94. [In Korean]
  7. Lee JH, Jo DC, Moon SJ, Kong JC, Park TY, Ko YS, et al. Narrative review of clinical trials on hominis placenta pharmacopuncture in Korean literature. J Oriental Rehab Med 2012;22:79-88. [In Korean]
  8. Kim YH, Shin MS, Choi SW, So WR. Research about the physical reaction to appear in herbal acupuncture operating. J Pharmacopuncture 2003;6:38-46. [In Korean] https://doi.org/10.3831/KPI.2003.6.1.038
  9. Yook TH, Sin MS. Clinical study on the thermal temperature changes after hominis placenta acupuncture therapy. The Acupuncture 2002;19:88-94. [In Korean]
  10. Kim BH, Shin MS, Yook TH. Clinical study on the thermal temperature changes on herbal acupuncture therapy. The Acupuncture 2002;19:124-135. [In Korean]
  11. Cho TH, Park SS, Park KM. Efficacy of human placental extract pharmacopuncture into Kwanwon on fatigue in students. J Korean Oriental Med 2013;34:29-34. [In Korean] https://doi.org/10.13048/jkm.13004
  12. Kim TH, Park KY, Park JY. The effect of hominis placenta herbal acupuncture therapy on postpartum women's heat feeling, sweat and thirst. J Korean Obstet Gynecol 2010;23:139-155. [In Korean]
  13. Kim SM, Jang SH, Kim CH, Youn HM, Song CH, Ahn CB, et al. Effect of hominis placenta pharmacopuncture on dysmenorrhea. J Pharmacopuncture 2008;11:123-146. [In Korean] https://doi.org/10.3831/KPI.2008.11.3.123
  14. Rho JH. The effect of hominis placenta pharmacopuncture on leg spasticity of stroke patients-a pilot study, double blind, randomized, controlled clinical trial [dissertation]. Busan: Dong Eui University, 2011. [In Korean]
  15. Park JH, Jang SH, Lee CH, Ku JY, Jeun DS, Ahn CB, et al. Clinical research of the effectiveness of pharmacopuncture complex therapy on peripheral facial paralysis-hominis placenta pharmacopuncture therapy and sweet bee venom therapy. The Acupuncture 2010;27:79-87. [In Korean]
  16. Jun HJ, Nam SS, Kim YS. Neuroprotection of dopaminergic neurons by hominis placenta herbal acupuncture in in vitro and in vivo models of Parkinson's disease induced by MPP+/MPTP toxicity. The Acupuncture 2015;32:23-26.
  17. Hong TK, Kim JH, Woo JY, Ha KT, Joo MS, Hahn YB, et al. Stimulative effects of hominis placental pharmacopuncture solution combined with Zinc-oxide nanoparticles on RAW 264.7 cells-ZnO HPPS more easily stimulates RAW 264.7 cells. J Pharmacopuncture 2012;15:13-8. https://doi.org/10.3831/KPI.2012.15.001
  18. Yang SE, Kim YS, Park DS. Human placental extract suppresses lipopolysaccharide-induced expression of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. The Acupuncture 2005;22:111-121. [In Korean]
  19. Hwang JH, Cho HS, Lee HJ, Lee DG, Jeong WJ, Jung CY, et al. Effect of inhibition macrophage migration inhibitory factor activation by hominis placenta herbal acupuncture on rheumatic arthritis. The Acupuncture 2008;25:1-11. [In Korean]
  20. Park KB, Baek ST, Lee SD, Kim KH, Kim KS. The effect of hominis placenta herbal acupuncture on reducing expression of LPS-induced arthritis model as an anti-inflammatory agent. The Acupuncture 2006;23:103-115. [In Korean]
  21. Jang HS, Lee KM, Lim SC, Eom DM, Seo JC. Microarray analysis of gene expression in Raw 264.7 cells treated with hominis placenta herbal acupuncture solution. J Korean Oriental Med 2006;12:131-141. [In Korean]
  22. Seo JC, Lee JD, Park DS, Kang SK, Ahn BC, Kim EH, et al. Protective mechanism of hominis placenta extract against H2O2-induced apoptosis in PGT-b cells. J Korean Oriental Med 2001;22:92-97.
  23. Seo JC, Lee JD, Park DS, Kang SK, Ahn BC, Kim EH, et al. Preventive effects of hominis placenta extract on H2O2-induced apoptosis in pineal gland cell line. The Acupuncture 2001;18:69-78.
  24. Seo HS. The effects of hominis placenta extract on melanin synthesis of B16 melanoma cells. J Pharmacopuncture 2006;9:75-82. [in Korean] https://doi.org/10.3831/KPI.2006.9.1.075
  25. Yang L, Deng Y. Hominis placenta promotes melanocyte proliferation, melanin synthesis and tyrosinase activity in vitro. Di Yi Jun Yi Da Xue Xue Bao 2004;29:1040-1041.
  26. Lee YH, Yoon HM, Jang KJ, Kim CH. A pilot study on single-dose toxicity testing of hominis placenta pharmacopuncture in Sprague-Dawley rats. J Pharmacopuncture 2015;18:51-59.
  27. Lee JM. Effects of hominis placenta pharmacopuncture on the blood picture and antioxidative activity in rats. Korean J Acupunct 2009;26:53-60. [In Korean]
  28. Jo YW, Lee SW, Kang MJ, Kim EJ, Lee SD, Kim KS. Effect of hominis placenta herbal acupuncture on type II collagen-induced arthritis in mice. The Acupuncture 2007;24:75-88. [In Korean]
  29. Yeom MJ, Kang JE, Hahm DH, Park JH, Park HJ, Lee EJ, et al. Therapeutic effects of hominis placenta herb-acupuncture in adjuvant-induced arthritis rat. J Pharmacopuncture 2002;5:91-103. [In Korean] https://doi.org/10.3831/KPI.2002.5.1.091
  30. Yeom MJ, Lee HC, Kim GH, Shim IS, Lee HJ, Hahm DH. Therapeutic effects of hominis placenta injection into an acupuncture point on the inflammatory responses in subchondral bone region of adjuvant-induced polyarthritic rat. Biol Pham Bull 2003;26:1472-1477. https://doi.org/10.1248/bpb.26.1472
  31. Park JY, Lee JY, Jeong MS, Min SR, Kim SY, Lee HJ, et al. Effect of hominis placenta on cutaneous wound healing in normal and diabetic mice. Nutrition RP 2014;8:404-409.
  32. Jeong MS. Wound healing effects of hominis placenta pharmacopuncture in diabetic mice [dissertation]. Seoul: Kyung Hee University, 2012. [In Korean]
  33. You JH, Choi DY, Kang SG. Renoprotective effect of hominis placenta aquaacupuncture in streptozotocin induced diabetic rats. The Acupuncture 2002;19:152-166. [In Korean]
  34. Lee BH, Park SY, Choi CH, Lee EK, Chung DK. The effects of hominis placenta herbal-acupuncture solution on the Alzheimer's disease model induced by ${\beta}A$. J Oriental Neuropsychiatry 2008;19:41-64. [In Korean]
  35. Kim EJ, Kim GY. Effects of hominis placenta pharmacopuncture and electroacupuncture neuroprotection in contused spinal cord of rats. Korean J Oriental Physiol Pathol 2011;25:257-263. [In Korean]
  36. Seo TB, Han IS, Yoon JH, Seol IC, Kim YS, Jo HK, et al. Growth-promoting activity of hominis placenta extract on regenerating sciatic nerve. Acta Pharmacologica Sinica 2006;27:50-58. https://doi.org/10.1111/j.1745-7254.2006.00252.x
  37. Yoo YK, Kim HJ, Sin MR, Lee DN. Effects of hominis placenta pharmacopuncture therapy on experimentally-induced endometriosis in rats. J Korean Obstet Gynecol 2014;27:101-119. [In Korean] https://doi.org/10.15204/jkobgy2014.27.1.101
  38. Lee SJ. Immunomodulatory effects of hominis placenta extract injection into an acupuncture point on the experimental subcutaneous tumor model of mice. Korean J Oriental Physiol Pathol 2006;20:1285-1289.
  39. Lim JT, Park YC. Effects of hominis placenta herbal acupuncture on immune cells and cytokines in OVA-induced asthmatic mice. Korean J Oriental Physiol Pathol 2005;19:446-451. [In Korean]
  40. Lee SK, Seo JC, Choi DY, Park DS, Lee YH, Kang SK. Effects of hominis placenta aqua-acupuncture on kidney and liver intoxicated by HgCl2 in rats. J Pharmacopuncture 2000;3:191-212. [In Korean] https://doi.org/10.3831/KPI.2000.3.2.191
  41. Lim SC, Seo JC, Lee KM, Lee BH, Lee YK, Jung TY, et al. Scavenging effect of hominis placenta herbal acupuncture solution on nitric oxide. The Acupuncture 2007;24:99-105.
  42. Seo GY, Lee SW, Park SJ, Kim SC, Sohn IC, Hwang SY, et al. Biological activities of hominis placenta herbal acupuncture prepared by hydrochloric acid hydrolysis. J Pharmacopuncture 2010;13:5-12. [In Korean]
  43. Park SW, Lee JW, Lee JH, Ha IH, Byun JH, Jung BH, et al. Identification of standard compound of Ja-ha-guh pharmacopuncture and validation of analytic methods. J Oriental Rehab Med 2016;26:33-40. [In Korean]
  44. Yoon JS, Seo JC, Lee HS, Lim SC, Jung TY, Shin LH, et al. Hwangryunhaedoktang herbal acupuncture and hominis placenta herbal acupuncture. The Acupuncture 2004;21:197-206. [In Korean]
  45. Lee SK, Lee JD, Koh HK, Park DS, Lee YH, Kang SK. Study on the hominis placenta aqua-acupuncture solution. The Acupuncture 2000;17:67-74. [In Korean]
  46. Miao WL, Fang KH, Qiu YJ, Ding Q, Wu Y, Hu HB. Quality and management recommendations of hominis placenta. Pharm Clin Res 2015;23:521-523.
  47. Lim DO, Jung MJ, Park JS, Seo KS Hwang JO, Kim EY, et al. Survey on Korean medicine use and Korean herbal medicine consumption. Korea Health Industry Development Institute 2014;1:664-9. [In Korean]
  48. Park BK, Cho JH, Son CG. Randomized clinical controlled trials with herbal acupuncture (pharmacopuncture) in Korea?a systematic review. J Korean Oriental Med 2009;30:115-126. [In Korean]
  49. Lee DJ, Hwangbo M, Kwon K, Seo HS. Review of cervi cornu parvum pharmacopuncture in Korean medicine. J Pharmacopuncture 2013;16:7-14.
  50. Yun HS, Kim YS, Lee JD. Study on bee venom and pain. J Pharmacopuncture 2000;3:157-175. [In Korean] https://doi.org/10.3831/KPI.2000.3.1.157

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