Textile Science and Engineering (한국섬유공학회지)

The Korean Fiber Society (한국섬유공학회)
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Fabrication and Characterization of PLA Sheath-core Nanofibers by Coaxial Electrospinning

동축 전기방사를 통해 제조된 PLA Sheath-core 나노섬유의 제조 및 특성분석

  • Kim, Min Hee (Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University) ;
  • Kim, Hee Cheol (Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University) ;
  • Park, Won Ho (Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University)
  • 김민희 (충남대학교 공과대학 유기소재.섬유시스템공학과) ;
  • 김희철 (충남대학교 공과대학 유기소재.섬유시스템공학과) ;
  • 박원호 (충남대학교 공과대학 유기소재.섬유시스템공학과)
  • Received : 2017.11.09
  • Accepted : 2017.12.08
  • Published : 2017.12.31
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Abstract

In this study, poly(lactic acid) (PLA) nanofibers with sheath-core structure was prepared by coaxial electrospinning. The morphology of PLA sheath-core nanofibers was characterized using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The PLA nanofibers with sheath-core structure was successfully fabricated by coaxial electrospinning, and the loading of model drug was controlled by solution feed ratio. In addition, the dual drug release of PLA nanofibers was evaluated in the physiological media. From the results, the cumulative release rate of model drug in sheath part was higher than that in core part. The PLA sheath-core nanofibers has a great potential for drug delivery system and scaffolds for tissue engineering.

Keywords

References

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